Destiny Shared "Pharmacology" - 43 Picmonics

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Pharmacology

Class I Antiarrhythmics (Na+ Channel Blockers) Overview
Indications
Arrhythmias
Local Anesthesia
Mechanism of Action
Block or Slow Conduction
Block Na+ Channels
Raise Threshold
State Dependent
Contraindication
Hyperkalemia
1 min
Class IA Antiarrhythmics (Na+ Channel Blockers)
Indications
Arrhythmias
Mechanism of Action
Increase AP, ERP, and QT interval.
Drugs
Disopyramide
Procainamide
Drug-induced Lupus
Quinidine
Cinchonism
Shared Side Effects
Thrombocytopenia
Torsades de Pointes
1 min
Class IB Antiarrhythmics (Na+ Channel Blockers)
Indications
Arrhythmias
After Myocardial Infarction
Mechanism of Action
Affect Ischemic Tissue
Decrease AP duration
Drugs
Mexiletine
GI Upset
Lidocaine
CNS Depression
Tocainide
Phenytoin
Hirsutism
2 mins
Class IC Antiarrhythmics (Na+ Channel Blockers)
Indications
Used as Last Resort
V-Tach
Mechanism of Action
No Effect on AP Duration
Drugs
Propafenone
Flecainide
Contraindications
Post-Myocardial Infarction
55 secs
Class III Antiarrhythmics (K+ Channel Blockers)
Indications
Arrhythmias
Mechanism of Action
Increase AP Duration, ERP, and QT Interval
Drug Names
Amiodarone
Check Function Tests
Dirty Drug
Ibutilide
Dofetilide
Sotalol
Beta-Blocker
2 mins
Class IV Antiarrhythmics (Ca2+ Channel Blockers)
Indications
SVT
Subarachnoid Hemorrhage
Mechanism of Action
Decrease Conduction Velocity
Increase PR Interval and ERP
Drugs
Verapamil
Diltiazem
Nimodipine
Side Effects
Cardiovascular
Constipation
2 mins
Magnesium Sulfate
Mechanism
Muscle Relaxant
Indications
Preterm Labor Contractions
Preeclampsia
Side Effects
Warm Feeling
Hypotension
Decreased Deep Tendon Reflexes (DTRS)
Decreased Respiratory Rate
Decreased Urine Output
Paralytic Ileus
Antidote
Calcium Gluconate
2 mins
Adenosine (Adenocard)
Mechanism
Slows AV Conduction
Indications
Supraventricular Tachycardia (Paroxysmal)
Side Effects
Bradycardia
Flushing
Dyspnea
Considerations
Rapid IV Push
Caffeine and Theophylline Decrease Effectiveness
Dipyridamole May Intensify Effects
2 mins
Lidocaine
Mechanism
Blocks Na+ Channels
Indications
Ventricular Arrhythmia
Anesthetic
Side Effects
Paresthesias
Seizures
Respiratory Depression
Drowsiness
Consideration
Anesthetic Effects Extended with Epinephrine
1 min
Beta Blocker Antidote
Antidote
Glucagon
28 secs
Loop Diuretics
Mechanism of Action
Thick Ascending Limb of Loop of Henle
Inhibits Na+-K+-2Cl-
Sulfa Drug
Drug Names
Furosemide
Lasix
Side Effects
Gout
Ototoxicity
Hypocalcemia
Hypokalemia
4 mins
Thiazide Diuretics
Early Distal Tubule
Inhibits NaCl Reabsorption
Sulfa Drug
Hyperglycemia
Hyperlipidemia
Hypercalcemia
Hyperuricemia
Hyponatremia
Hypokalemic Metabolic Alkalosis
2 mins
Selective Alpha-1 Blockers
"-osin" suffix
Mechanism of Action
Blocks Alpha1 Receptors
Indications
Hypertension
Benign Prostatic Hyperplasia (BPH)
Side Effects
Syncope
Orthostatic Hypotension
1 min
Cardiovascular Effects of Beta-Blockers
Cardiac Myocytes and Vasculature
Decrease cAMP
Decreases SA and AV Node Conduction Velocity
Lower Blood Pressure
Decrease O2 Consumption
Decreases Mortality Post-MI
2 mins
Selective Beta-1 Blockers
Characteristics
"-olol" Suffix
Drug Names
Beta-1 selective
Atenolol
Esmolol
Metoprolol
Partial Beta agonists
Acebutolol
1 min
Hydralazine
Indications
Reduce Afterload
Severe Hypertension
Safe during Pregnancy
CHF
Mechanism of Action
Increases cGMP
Vasodilates Arterioles
Side Effects
Drug-induced Lupus
Reflex Tachycardia
1 min
Nitroprusside
Mechanism of Action
Direct Release of NO
Increase cGMP
Short Half-Life
Indications
Malignant Hypertension
Side Effect
Cyanide Toxicity
1 min
K+ Sparing Diuretics
Indications
CHF and Hypertension
Hypokalemia
Hyperaldosteronism
Mechanism of Action
Collecting Tubule
Spironolactone
Competitive Aldosterone Receptor Antagonist
Amiloride and Triamterene
Block Na+ Channels
Side Effects
Hyperkalemia
Gynecomastia
2 mins
ACE Inhibitors
-Pril Suffix
Indications
Hypertension
CHF
Diabetic Nephropathy
Mechanism of Action
Inhibits ACE
Decreases GFR
Inhibits Constriction of Efferent Arteriole
Side Effect
Increased Bradykinin
Cough
1 min
ACE Inhibitor Toxicity
CAPTOPRIL Mnemonic
Cough
Angioedema
Potassium Changes (Hyperkalemia)
Taste Change
Hypotension
Pregnancy Changes
Rash
Increased Renin
Lower Angiotensin II
2 mins

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