Glen Shared "Copy of My Picmonics" - 53 Picmonics
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Copy of My Picmonics
NSAID names
- NSAID drug names
- Ibuprofen
- Naproxen
- Indomethacin
- Ketorolac
- Diclofenac
Leflunomide
- Function
- Reversibly inhibits dihydroorotate dehydrogenase
- Inhibits pyrimidine synthesis
- T-cell suppression
- Clinical use
- Rheumatoid arthritis
- Psoriatic Arthritis
- Side Effects
- Diarrhea
- Hypertension
- Hepatotoxicity
- Teratogenic
Polymyalgia Rheumatica
- Symptoms
- Shoulder and hip pain and stiffness
- Fever
- General Malaise
- Weight loss
- No muscular weakness
- Women over 50
- Temporal (giant cell) Arteritis
- Low-dose corticosteroids
Fibromyalgia
- Women 20-50 years old
- Chronic, widespread musculoskeletal pain
- Stiffness
- Paresthesias
- Poor sleep
- Treatment
- Exercise
- Antidepressants and anticonvulsants
Hepatitis C therapy
- Interferon alpha
- Flu symptoms, neutropenia, myopathy
- Depression
- Ribavirin
- Competitively inhibits inosine monophosphate dehydrogenase
- Inhibiting guanine nucleotides
- Hemolytic anemia
- Teratogen
- Sofosbuvir
- Inhibits RNA dependent RNA polymerase
- Causing chain termination
- Headache
- Fatigue
- Nausea
- Simeprevir
- Protease Inhibitor
- Prevents viral replication
- Photosensitivity
- Rash
Tinea (dermatophytes)
- Septate hyphae
- Tinea capitis
- Head and scalp
- Lymphadenopathy, alopecia, and scaling
- Tinea corporis
- On torso
- Erythematous scaling rings (ringworm) w/ central clearing
- Can get from infected dog or cat
- Tinea cruris
- Infects inguinal region
- Tinea pedis (three types)
- Interdigital (most common)
- Moccasin distribution
- Vesicular
- Tinea unguium
- Onychomycosis
Alpha-Thalassemia
- Alpha alleles on chromosome 16
- Microcytic, Hypochromic Anemia
- 2 Deletions
- Trans deletion more common in blacks
- Alpha-globin cis deletion more common in asians
- Three deletions
- 3 deletions yields B4 (HbH)
- 4 deletions
- 4 deletions = hydrops fatalis
- Hb Barts
Langerhan's Cell Histiocytosis
- Symptoms
- Proliferative disorder of dendritic Cells
- Lytic bone lesions in childhood
- Rash
- Mastoid bone mass
- Recurent otitis Media
- Cannot effectively activate T-cells
- Labs
- Express S100
- Express CD1a
- Birbeck granules
- Look like tennis rackets
Myelodysplastic sydromes
- Stem cell disorder
- Causes ineffective hematopoiesis
- De novo mutations or environmental exposures
- Radiation
- Benzene
- Chemotherapy
- Can turn into AML
- Pseudo-Pelger-Huet anomaly
- Bilobed neutrophils
Immune thrombocytopenia
- Anti IgG GpIIb/IIIa antibodies
- Splenic macrophage consumes platelet-antibody complex
- Increased megakaryocytic on bone marrow biopsy
- LP - Low Platelet Counts
- Increased Bleeding time
- Causes
- Viral infection
- Autoimmune disorders
- Drug reaction
- Treatment
- Steroids
- IVIG (Intravenous Immunoglobulin)
- Splenectomy
Cladribine
- Purine analog
- Inhibits DNA polymerase
- DNA strand breaks
- S Phase
- Indication
- Hairy Cell Leukemia
- Adverse Effects
- Myelosuppression
- Nephrotoxicity
- Neurotoxicity
Myelofibrosis
- Bone marrow obliterated by fibrosis
- Increased fibroblast activity
- Massive splenomegaly
- Labs
- Teardrop RBCs
- Anemia
- 30-50% have JAK2 mutation
Direct Thrombin Inhibitors
- Drugs
- Bivalirudin
- Argatroban
- Dabigatran (oral medication)
- Mechanism
- Inhibits activity of thrombin
- Indications
- Venous Thromboembolism (VTE)
- Atrial fibrillation
- Heparin Induced Thrombocytopenia (HIT)
- Adverse effects
- Bleeding
- Treat with Idaruvizumab
Nitrosoureas
- Requires Bioactivation
- Crosses Blood-Brain Barrier
- Alkylating agent
- Cross-Links DNA
- Indication
- Brain tumors
- Including Glioblastoma Multiforme
- Adverse effects
- CNS Toxicity
- Convulsions
- Dizziness
- Ataxia
Paclitaxel
- Stabilizes microtubules in M phase
- Anaphase cannot occur
- Indications
- Ovarian Carcinoma
- Breast carcinoma
- Adverse effects
- Myelosuppression
- Neuropathy
- Hypersensitivty
- Alopecia
Irinotecan and Topotecan
- Inhibits Topoisomerase I
- Prevents DNA unwinding and replication
- Indications
- Colon cancer (irinotecan)
- Ovarian and Small Cell Lung Cancer (topotecan)
- Adverse effects
- Severe myelosuppression
- Diarrhea
Erlotinib and Cetuximab
- Erlotinib
- EGFR tyrosine kinase inhibitor
- Treats Non-small Cell Lung Cancer
- Causes a rash
- Cetuximab
- Monoclonal antibody against EGFR
- Treats stage IV colorectal cancer
- With KRAS mutation
- Head and Neck Cancer
- Causes Rash
- Causes Diarrhea
- Causes Elevated Liver Enzymes
Bortezomib and Carfilzomib
- Mechanism
- Proteasome inhibitor
- Induces arrest at G2-M phase
- Apoptosis
- Clinical use
- Multiple myeloma
- Mantle Cell Lymphoma
- Adverse effects
- Peripheral neuropathy
- Reactivation of Herpes Zoster
Rasburicase
- Mechanism
- Recombinant uricase
- Catalyzes metabolism of uric acid to allantoin
- Clinical use
- Tumor lysis syndrome (treatment and prophylaxis)
- Also use aggressive hydration and allopurinol
Cytarabine
- Mechanism
- Pyrimidine analog
- Inhibits DNA Polymerase
- Clinical use
- Acute myelogenous leukemia (AML)
- Lymphomas
- Adverse effects
- Myelosuppression
- Megaloblastic anemia
- Pancytopenia
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