Glen Shared "Copy of My Picmonics" - 53 Picmonics

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Copy of My Picmonics

NSAID names
NSAID drug names
Ibuprofen
Naproxen
Indomethacin
Ketorolac
Diclofenac
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Leflunomide
Function
Reversibly inhibits dihydroorotate dehydrogenase
Inhibits pyrimidine synthesis
T-cell suppression
Clinical use
Rheumatoid arthritis
Psoriatic Arthritis
Side Effects
Diarrhea
Hypertension
Hepatotoxicity
Teratogenic
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Polymyalgia Rheumatica
Symptoms
Shoulder and hip pain and stiffness
Fever
General Malaise
Weight loss
No muscular weakness
Women over 50
Temporal (giant cell) Arteritis
Low-dose corticosteroids
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Fibromyalgia
Women 20-50 years old
Chronic, widespread musculoskeletal pain
Stiffness
Paresthesias
Poor sleep
Treatment
Exercise
Antidepressants and anticonvulsants
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Hepatitis C therapy
Interferon alpha
Flu symptoms, neutropenia, myopathy
Depression
Ribavirin
Competitively inhibits inosine monophosphate dehydrogenase
Inhibiting guanine nucleotides
Hemolytic anemia
Teratogen
Sofosbuvir
Inhibits RNA dependent RNA polymerase
Causing chain termination
Headache
Fatigue
Nausea
Simeprevir
Protease Inhibitor
Prevents viral replication
Photosensitivity
Rash
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Tinea (dermatophytes)
Septate hyphae
Tinea capitis
Head and scalp
Lymphadenopathy, alopecia, and scaling
Tinea corporis
On torso
Erythematous scaling rings (ringworm) w/ central clearing
Can get from infected dog or cat
Tinea cruris
Infects inguinal region
Tinea pedis (three types)
Interdigital (most common)
Moccasin distribution
Vesicular
Tinea unguium
Onychomycosis
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Alpha-Thalassemia
Alpha alleles on chromosome 16
Microcytic, Hypochromic Anemia
2 Deletions
Trans deletion more common in blacks
Alpha-globin cis deletion more common in asians
Three deletions
3 deletions yields B4 (HbH)
4 deletions
4 deletions = hydrops fatalis
Hb Barts
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Langerhan's Cell Histiocytosis
Symptoms
Proliferative disorder of dendritic Cells
Lytic bone lesions in childhood
Rash
Mastoid bone mass
Recurent otitis Media
Cannot effectively activate T-cells
Labs
Express S100
Express CD1a
Birbeck granules
Look like tennis rackets
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Myelodysplastic sydromes
Stem cell disorder
Causes ineffective hematopoiesis
De novo mutations or environmental exposures
Radiation
Benzene
Chemotherapy
Can turn into AML
Pseudo-Pelger-Huet anomaly
Bilobed neutrophils
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Immune thrombocytopenia
Anti IgG GpIIb/IIIa antibodies
Splenic macrophage consumes platelet-antibody complex
Increased megakaryocytic on bone marrow biopsy
LP - Low Platelet Counts
Increased Bleeding time
Causes
Viral infection
Autoimmune disorders
Drug reaction
Treatment
Steroids
IVIG (Intravenous Immunoglobulin)
Splenectomy
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Cladribine
Purine analog
Inhibits DNA polymerase
DNA strand breaks
S Phase
Indication
Hairy Cell Leukemia
Adverse Effects
Myelosuppression
Nephrotoxicity
Neurotoxicity
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Myelofibrosis
Bone marrow obliterated by fibrosis
Increased fibroblast activity
Massive splenomegaly
Labs
Teardrop RBCs
Anemia
30-50% have JAK2 mutation
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Direct Thrombin Inhibitors
Drugs
Bivalirudin
Argatroban
Dabigatran (oral medication)
Mechanism
Inhibits activity of thrombin
Indications
Venous Thromboembolism (VTE)
Atrial fibrillation
Heparin Induced Thrombocytopenia (HIT)
Adverse effects
Bleeding
Treat with Idaruvizumab
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Nitrosoureas
Requires Bioactivation
Crosses Blood-Brain Barrier
Alkylating agent
Cross-Links DNA
Indication
Brain tumors
Including Glioblastoma Multiforme
Adverse effects
CNS Toxicity
Convulsions
Dizziness
Ataxia
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Paclitaxel
Stabilizes microtubules in M phase
Anaphase cannot occur
Indications
Ovarian Carcinoma
Breast carcinoma
Adverse effects
Myelosuppression
Neuropathy
Hypersensitivty
Alopecia
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Irinotecan and Topotecan
Inhibits Topoisomerase I
Prevents DNA unwinding and replication
Indications
Colon cancer (irinotecan)
Ovarian and Small Cell Lung Cancer (topotecan)
Adverse effects
Severe myelosuppression
Diarrhea
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Erlotinib and Cetuximab
Erlotinib
EGFR tyrosine kinase inhibitor
Treats Non-small Cell Lung Cancer
Causes a rash
Cetuximab
Monoclonal antibody against EGFR
Treats stage IV colorectal cancer
With KRAS mutation
Head and Neck Cancer
Causes Rash
Causes Diarrhea
Causes Elevated Liver Enzymes
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Bortezomib and Carfilzomib
Mechanism
Proteasome inhibitor
Induces arrest at G2-M phase
Apoptosis
Clinical use
Multiple myeloma
Mantle Cell Lymphoma
Adverse effects
Peripheral neuropathy
Reactivation of Herpes Zoster
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Rasburicase
Mechanism
Recombinant uricase
Catalyzes metabolism of uric acid to allantoin
Clinical use
Tumor lysis syndrome (treatment and prophylaxis)
Also use aggressive hydration and allopurinol
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Cytarabine
Mechanism
Pyrimidine analog
Inhibits DNA Polymerase
Clinical use
Acute myelogenous leukemia (AML)
Lymphomas
Adverse effects
Myelosuppression
Megaloblastic anemia
Pancytopenia
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