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NUR114 Unit 2
Cholesterol Lab Values
LDL (Low Density Cholesterol)
< 100 mg/dL
HDL (High Density Cholesterol)
> 40 mg/dL Males
> 50 mg/dL Females
Total Cholesterol
< 200 mg/dL
1 min
Statins
Rhabdomyolysis
Hepatotoxicity
HMG-CoA reductase inhibitors
Decrease LDL
Decrease Triglycerides
Increase HDL
2 mins
Fibrates
Indications
Hyperlipidemia
Mechanism of Action
Upregulate LPL
Decreases Triglycerides
Slight Increase in HDL
Slight Decrease in LDL
Side Effect
Hepatotoxicity
Cholesterol Gallstones
1 min
Arteriosclerosis
Arteriolosclerosis
Small & Medium-sized Arteries
Endothelial Damage
Hypertrophy of Smooth Muscle Cell Matrix
Hyaline arteriolosclerosis
Diabetic Angiopathy
Hyperglycemic Injury
Hyperplastic arteriolosclerosis
Malignant Hypertension
Laminated Onion-skin Arteriolar Thickening
Duplicated Basement Membrane
Fibrin Deposition (Fibrinoid Necrosis)
Necrotizing Arteriolitis
Monckeberg Medial Sclerosis
Monckeberg Medial Sclerosis
Medial Calcifications in Muscular Arteries
Greater Than 50 Years Old
Subclinical (non-obstructive)
Atherosclerosis
Atherosclerosis
Medium & Large Arteries
Intimal Lesion
Elastic and Muscular Arteries
Atherosclerosis
Very common. Disease of elastic arteries and large- and medium-sized muscular arteries.
A form of arteriosclerosis caused by buildup of cholesterol plaques
Labetalol (hybdrid carved in Lab = mixed alpha and beta antagonist)
Nicardipine = CCB
Clevidipine (Another CCB)
Angina & Treatment (USD SSOM)
Types
Typical Angina
Variant Angina
Microvascular Angina
Medications
Nitrates
Beta Blockers
Calcium Channel Blockers
Ranolazine
Ivabradine
7 mins
Drugs to treat Peripheral Vascular Disease
Pentoxifylline(Trental TM)
Form of pentoxifylline
side effects of pentoxifylline
Drug interactions of Pentoxifylline
Cilostazol (Pletal TM)
form of Cilostazol
decreases Cilostazol effectiveness
common Side effects of Cilostazol
serious Side effects of Cilostazol
vorapaxar
newer platelet aggregation inhibitor
Antihypertensive vasodilating classes used to treat spasticity of vessels
Calcium Channel Blockers
Alpha blockers
Direct vasodilators
Ace Inhibitors
patient education related to the prevention/treatment of Peripheral Vascular Disease
Keep extremities warm
Don't stand or sit in dependant position for long periods of time
control blood pressure
stopping smoking
begin daily exercise
reduce intake of saturated fats
2 mins
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