Charles Shared "Pharm 2 - Exam 4" - 20 Picmonics
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Pharm 2 - Exam 4
Cushing's Syndrome Assessment
- Assessment
- Increased Cortisol Levels
- Truncal Obesity
- Purple Abdominal Striae
- Buffalo Hump
- Decreased Bone Density
- Moon Face
- Thinning Skin
- Hyperglycemia
- Hypertension
- Considerations
- Long Term Glucocorticoid Use
- Immunosuppression
2 mins
Addison's Disease Intervention
- Drug Therapy
- Hydrocortisone
- 2/3 Dose in Morning
- 1/3 Dose in Late Afternoon
- Fludrocortisone
- Androgen Replacement Therapy
- Considerations
- Salt Additives
- Increase Dosage During Stress and Infection
- Medic Alert Bracelet
- Lifelong Hormone Therapy
2 mins
Addison's Disease Assessment
- Assessment
- Deficiency of Cortisol and Aldosterone
- Irritability
- Hyperkalemia
- Muscle Weakness
- Skin Hyperpigmentation
- Hyponatremia
- Hypotension
- Hypoglycemia
- Considerations
- Addisonian Crisis
2 mins
Syndrome Of Inappropriate Antidiuretic Hormone (SIADH)
- Pathophysiology
- Hypersecretion of ADH
- Increased Sensitivity to ADH
- Signs & Symptoms
- Serum Hypoosmolality
- Coma and Seizure
- Dilutional Hyponatremia
- Cramps and Tremors
- Euvolemia
- Change in LOC
2 mins
Syndrome of Inappropriate Antidiuretic Hormone (SIADH) Pharmacologic Interventions
- Diuretics
- Hypertonic IV Fluids
- Demeclocycline
- Tolvaptan and Conivaptan
1 min
Syndrome of Inappropriate Antidiuretic Hormone (SIADH) Nonpharmacologic Interventions
- Monitor Serum and Urine Osmolality
- IandOs with Daily Weights
- Restrict Fluid Intake
- Monitor Cardiovascular and Neurological Status
- Seizure Precautions
2 mins
Propylthiouracil (PTU) and Methimazole (MMI)
- Indications
- Hyperthyroidism
- Mechanism
- Inhibits Thyroid Peroxidase
- PTU Blocks Peripheral Conversion of T4 to T3
- Side Effects
- Agranulocytosis
- Skin Rash
- Hepatotoxicity (PTU)
- Teratogen (MMI)
1 min
Levothyroxine (Synthroid)
- Mechanism
- Synthetic T4
- Indications
- Hypothyroidism
- Side Effects
- Thyrotoxicosis
- Tremors
- Heat Intolerance
- Insomnia
- Tachycardia
- Considerations
- Do Not Use for Obesity
- TSH Monitoring
2 mins
Metformin (Glucophage)
- Mechanism
- Decrease Glucose Production
- Increase Insulin Sensitivity
- Indications
- Type 2 Diabetes
- Polycystic Ovary Syndrome (PCOS)
- Side Effects
- GI Distress
- Decreased Appetite
- Lactic Acidosis
- Considerations
- IV Contrast
- Limit Alcohol Consumption
2 mins
Iron Deficiency Anemia
- Causes
- Malnutrition/Malabsorption
- Hemorrhage
- Signs
- Microcytic, Hypochromic Anemia
- Decreased Heme Synthesis
- Labs
- Decreased Reticulocytes
- Decreased Ferritin
- Increased Red Cell Distribution Width (RDW)
- Poikilocytosis
- Anisocytosis
- Increased Central Pallor
2 mins
Cobalamin (Vitamin B12)
- Mechanism
- Vitamin B12
- Indications
- Vitamin Deficiency
- Pernicious Anemia
- Side Effects
- Hypokalemia
- Arthralgia
- Dizziness
- Considerations
- IM Injection for Pernicious Anemia
- Never Give IV
2 mins
Tamoxifen
- Mechanism of Action
- Selective Estrogen Receptor Modulator (SERM)
- Antagonist on Breast Tissue
- Indications
- ER-positive Breast Cancer
- Side Effects
- Decreased Risk of Osteoporosis
- Increased Risk of Endometrial Cancer
- Increased Risk of Venous Thromboembolism (VTE)
1 min
Somatostatin
- Secreted by D Cells
- Pancreas
- GI Tract
- Action
- Decrease Secretion of Gastric Acid and Pepsinogen
- Decrease Pancreatic and Small Intestine Fluid Secretion
- Decrease Gallbladder Contraction
- Decrease Glucagon and Insulin Secretion
- Regulation
- Secretion is Increased by Acid
- Secretion is Decreased by Vagal Stimulation
- Clinical Use
- Octreotide
- Carcinoid Syndrome
- Variceal Bleeds
2 mins
Insulin
- Rapid Acting
- Insulin Lispro (Humalog)
- Insulin Aspart (Novolog)
- Insulin Glulisine (Apidra)
- Short Acting
- Regular Insulin (Humulin R)
- Intermediate Acting
- Isophane NPH (Humulin N)
- Long Acting
- Detemir (Levemir)
- Glargine (Lantus)
2 mins
Repaglinide and Nateglinide (Meglitinides)
- Mechanisms
- Meglitinides
- Increased Insulin Release
- Indications
- Type 2 Diabetes
- Side Effect
- Hypoglycemia
- Considerations
- Eat Within 30 Minutes
- Gemfibrozil Increases Risk of Hypoglycemia
- Short Half-Life
2 mins
Acarbose (Precose) and Miglitol (Glyset) (Alpha Glucosidase Inhibitors)
- Mechanisms
- Alpha Glucosidase Inhibitors
- Delays Absorption of Carbohydrates
- Indications
- Type 2 Diabetes
- Side Effects
- Flatulence
- Diarrhea
- Anemia
- Cramps
- Considerations
- Monitor LFTs
- Oral Glucose for Hypoglycemia
2 mins
Pioglitazone (Thiazolidinediones)
- -glitazones Suffix
- Mechanism
- Binds PPAR-Gamma
- Decreases Insulin Resistance
- Indications
- Type 2 Diabetes
- Side Effects
- Weight Gain
- Heart Failure
- Myalgia
- Hypoglycemia
- Upper Respiratory Infection
- Considerations
- Increased Risk of Bladder Cancer
- Increased Fracture Risk in Women
- Monitor Liver Enzymes
2 mins
Iron (Ferrous Sulfate)
- Mechanism
- Ferrous Salts
- Indications
- Anemia
- Side Effects
- GI Distress
- Nausea and Vomiting
- Dark Stools
- Considerations
- Take Between Meals
- Liquid can Stain Teeth
- Keep out of Reach from Children
- Caution with GI Disorders
- Avoid Antacids
3 mins
Cyclophosphamide
- Mechanism
- Requires Bioactivation by Liver
- Cross-links DNA
- Guanine N7 Position
- Indications
- Autoimmune Disorders
- Leukemia
- Lymphoma
- Solid Tumors
- Side Effects
- Myelosuppression
- Hemorrhagic Cystitis
- Prevent with Mesna
3 mins
Methotrexate
- Indications
- Rheumatoid Arthritis
- Cancer
- Medical Abortion
- Mechanism
- Folic Acid Analog
- Inhibits Dihydrofolate Reductase
- Side Effects
- Pulmonary Fibrosis
- Myelosuppression is Treated with Leucovorin Rescue (Folinic Acid)
- Macrocytic Anemia
- Hepatitis
- Teratogenic
- Mucositis
2 mins
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