shanteelyse Shared "Pharm 2 Week 1" - 24 Picmonics
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Pharm 2 Week 1
Cyclosporine (Sandimmune) Overview
- Mechanism
- Immunosuppressant
- Inhibits Calcineurin, Decreasing IL-2
- Indications
- Prevent Transplant Rejection
- Psoriasis
- Rheumatoid Arthritis
- Considerations
- Monitor Plasma Levels
- Avoid Grapefruit Juice
- Increased Risk of Lymphoma
2 mins
Cyclosporine (Sandimmune) Side Effects
- Side Effects
- Nephrotoxicity
- Hepatotoxicity
- Infection
- Hypertension
- Hirsutism
- Tremor
- Hyperkalemia
- Hypomagnesemia
- Gingival Hyperplasia
1 min
Innate Immunity Barriers
- Skin Protects Against Pathogens
- Normal Flora Outcompete Pathogens
- Lysozyme in Saliva, Tears, and Mucus
- Mucous Traps Pathogens
- Cilia Remove Mucus
- Acid and Digestive Enzymes in the Stomach Kill Pathogens
2 mins
Humoral Adaptive Immunity
- Characteristics
- B Cell Binds Free Floating Antigen
- B Cell Presents Antigen to Helper T Cell
- Helper T Cells Help B Cells Develop Antigen Specificity
- Plasma B Cells Secrete Antibodies
- Memory B Cells Cause Faster Secondary Response
2 mins
Cell-mediated Adaptive Immune Response
- Characteristics
- Macrophages and Dendritic Cells Present Antigens
- T Cell Develops Antigen Specificity
- Regulatory T Cells Suppress Response
- Memory T Cells Cause Faster Secondary Response
- Cytotoxic T Cells Lyse Infected Cells
- Infected Cells Present Antigen On Surface
2 mins
Innate Immunity Cellular Response
- Characteristics
- Natural Killer Lymphocytes Attack Abnormal Cells
- Neutrophils in Blood
- Infected Cells Release Interferon
- Complement Proteins Lyse Pathogens/Infected Cells
- Dendritic Cells in Tissue
- Macrophages in Tissue
2 mins
RhoGam [Rho(D) Immune Globulin]
- Indications
- Antepartum Prevention at 28 weeks
- Suppress Antibody Production
- Mechanism of Action
- Lysis of Fetal RBC in Maternal Bloodstream
- Side Effects
- Myalgia and Lethargy
- Considerations
- Negative Coombs Test
- Standard Dose 300 mcg
- Microdose 50 mcg
- Blood Product
2 mins
Live Attenuated Vaccines
- Characteristics
- Humoral and Cellular Immune Response
- May Revert to Virulent Form
- Do Not Require Boosters
- Vaccines
- Varicella (Chickenpox)
- Zoster (Shingles)
- Polio (Sabin)
- Smallpox
- Yellow Fever
- Influenza (Intranasal)
- MMR
- Rotavirus
- Typhoid Fever (Oral)
- BCG (Bacillus Calmette-Guérin)
4 mins
Killed (Inactivated) Whole Vaccines
- Characteristics
- Require Booster Shots
- Vaccines
- Mostly Humoral Immune Response
- Polio (Salk)
- Rabies
- Cholera
- Hepatitis A
54 secs
Varicella (Chickenpox)
- Mechanism
- Varicella Zoster Virus (VZV)
- Signs and Symptoms
- Red Maculopapular Rash
- Vesicles Ooze and Crust
- Pruritus
- Centripetal
- Considerations
- Varicella Immunization
- Skin Care to Minimize Itching
- Isolate until Vesicles Crust
2 mins
Toxoid Vaccines
- Consist of Toxins Released From a Pathogen
- May Require Boosters
- Safe In Immunocompromised Patients
- Corynebacterium Diphtheriae Vaccine
- Tetanus Vaccine
- Bordetella Pertussis Vaccine
2 mins
Human Papillomavirus (HPV)
- Characteristics
- Non-enveloped
- Circular
- Double Stranded DNA
- Disease
- Warts 1, 2, 6, 11
- Condyloma acuminata
- Type 16, 18
- Cervical Carcinoma
- Penile Carcinoma
- AIDS/Immunocompromised
- Worsened by Smoking
- Diagnosis
- Koilocytic change in squamous epithelium
- Pyknotic Nuclei Surrounded by Clear Halo
- Treatment
- Vaccine Available
4 mins
Hepatitis B Virus Disease
- Can turn chronic
- < 10% of adults become chronic carriers
- 90% of newborns become chronic carriers
- Cirrhosis
- Hepatocellular carcinoma
- Membranous Glomerulonephritis
- Polyarteritis nodosa
- Serum sickness like syndrome
2 mins
Pediatric Vaccinations Age 4-6 Years
- Very DIM between 4-6pm
- Varicella Zoster
- DTaP - Diphtheria Tetanus acellular pertussis
- IPV - Inactivated Polio Vaccine
- MMR
1 min
Rubella
- Mechanism
- Rubella Virus
- Signs and Symptoms
- Swollen Glands
- Cold-like Symptoms
- Pinkish-red Maculopapular Rash
- Low Grade Fever
- Considerations
- Rubella Titer
- Avoid Contact with Pregnant Women
- MMR Vaccination
2 mins
Pediatric Vaccinations - Age 12 to 15 Months
- 1 Very MAD HIP-ster
- Varicella Zoster
- MMR
- Hepatitis A
- DTaP - Diphtheria Tetanus acellular pertussis
- HiB - Haemophilus Influenzae Type B
- IPV - Inactivated Polio Vaccine
- PCV - Pneumococcal
2 mins
Influenza Virus
- Characteristics
- RNA Virus
- Orthomyxovirus
- Enveloped
- Negative Sense
- 8 Segments
- Helical
- Hemagglutinin for Viral Entry
- Neuraminidase for Virion Release
- Genetic Shift
- Reassortment of genome to cause major change
- Genetic Drift
- Minor Antigenic Mutations
- Considerations
- Reye Syndrome with Aspirin Use
- Guillain-Barre Syndrome
3 mins
Pediatric Vaccinations - Age 2 Months
- 2 B DR HIP
- Hepatitis B
- DTaP - Diphtheria Tetanus acellular Pertussis
- RV - Rotavirus
- HiB - Haemophilus Influenzae Type B
- IPV - Inactivated Polio Vaccine
- PCV - Pneumococcal
1 min
Pediatric Vaccinations - Age 4 Months
- 4 DR HIP
- DTaP - Diphtheria Tetanus acellular pertussis
- RV - Rotavirus
- HiB - Haemophilus Influenzae Type B
- IPV - Inactivated Polio Vaccine
- PCV - Pneumococcal
1 min
Haemophilus Influenzae Disease
- Disease
- Pneumonia
- Cherry Red Epiglottitis
- Meningitis
- Otitis Media
- COPD Exacerbation
- Thumbprint Sign (on X-ray)
- Treatment
- Rifampin Prophylaxis
- Ceftriaxone
2 mins
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