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Module 1 ICM
Selective IgA Deficiency
Defect in Class Switching
Signs and Symptoms
Increase in Atopic & Autoimmune Diseases
Increased Risk Giardia Lamblia Infections
Inflammatory Bowel Disease
Anaphylaxis From IgA Containing Blood Products
Thymic Aplasia (DiGeorge Syndrome)
Failure to Develop Third and Fourth Pharyngeal Pouches
Antibody Mediated Due to Preformed Antidonor Antibodies
Occurs within Weeks
Cytotoxic T Lymphocytes Cause Cell-mediated or Antibody-mediated Response
Occurs Months to Years Later
Antibody and T Cell-mediated Vascular Damage
Iron Deficiency Anemia
Microcytic, Hypochromic Anemia
Decreased Heme Synthesis
Increased Red Cell Distribution Width (RDW)
Increased Central Pallor
Microcytic Anemia Causes
MCV < 80
Chronic Disease or Illness
Late Iron Deficiency
Normocytic Nonhemolytic Anemia Causes
Anemia of Chronic Disease/Inflammation
Chronic Kidney Disease
Early Iron Deficiency
Normocytic Hemolytic Anemia Causes
RBC Enzyme Deficiency
Hemoglobin C Defect
Paroxysmal Nocturnal Hemoglobinuria (PNH)
Sickle Cell Anemia
Prosthetic Cardiac Valves
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