Katherine Shared "MICROBIOLOGY" - 123 Picmonics

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MICROBIOLOGY

HIV Prophylaxis Medications
CD4+ < 200
TMP-SMX
Pneumocystis Pneumonia
CD4+ < 100 Susceptible to Toxoplasma Gondii
CD4+ < 50
Mycobacterium Avium and Intracellulare
Azithromycin If Delayed Therapy
2 mins
HIV CD4+ 500
Signs and Symptoms
Candida albicans (Oral Thrush)
Kaposi's Sarcoma (HHV-8)
Human Papillomavirus (HPV)
Epstein-Barr Virus (Oral Hairy Leukoplakia)
3 mins
HIV CD4+ 200
Signs and Symptoms
Herpes Simplex Virus (HSV)
JC Virus
Progressive Multifocal Leukoencephalopathy (PML)
Pneumocystis Pneumonia
(HIV) Dementia
Histoplasmosis
3 mins
HIV CD4+ 100
Signs and Symptoms
Aspergillus fumigatus
Cryptococcus neoformans
Candida albicans (Esophagitis)
Mycobacterium avium complex (MAC)
Cytomegalovirus (CMV)
Epstein-Barr virus (EBV) B-cell lymphoma
Toxoplasma gondii
Cryptosporidium
Bartonella henselae
5 mins
Human Immunodeficiency Virus (HIV) Interventions
Interventions
Adequate Nutrition
Small Frequent Meals
IV Hydration
Emotional Support
HIV Medications
HAART
Considerations
Transmission Education
Strict Asepsis for Invasive Procedures
Treat Opportunistic Infections
2 mins
Human Immunodeficiency Virus (HIV) Diagnosis
HIV-1/2 Antigen/Antibody Immunoassay
HIV-1/2 Antibody Differentiation Immunoassay
Nucleic Acid Testing (NAT)
Viral Load
Polymerase Chain Reaction (PCR) in Neonates
3 mins
Human Immunodeficiency Virus (HIV) Assessment
Assessment
RNA Retrovirus
CD4+ Helper T Cells
Primary Infection
Flu-like Symptoms
Lymphadenopathy
Symptomatic Stage
Fatigue
Diarrhea
Unexplained Weight Loss
White Spots on Tongue
Persistent Fever
Night Sweats
2 mins
Human Immunodeficiency Virus (HIV) Stages
Primary Infection
Within 3 Weeks
Flu-like Symptoms
Asymptomatic Stage
Years
Symptomatic Stage
CD4+ < 500
AIDS
Opportunistic Infections
CD4+ < 200
2 mins
Fusion Inhibitors
Indications
HIV
Drugs
Maraviroc
Binds CCR-5 on T Cells
Blocks Interaction with gp120
Enfuvirtide
Binds gp41
Inhibits Viral Entry
Side Effects
Skin Reactions at Injection Sites (Enfuvirtide)
2 mins
HAART
HIV
Begin at Diagnosis
3 Drugs
2 NRTIs (Nucleoside Reverse Transcriptase Inhibitors)
And one of the following:
NNRTI (Non-Nucleoside Reverse Transcriptase Inhibitor)
or Protease Inhibitor
or Integrase Inhibitor
2 mins
NRTIs (Nucleoside Reverse Transcriptase Inhibitors)
Indications
HIV
Pregnancy and Prophylaxis given ZDV
Mechanism
Inhibit Nucleotide Binding to Reverse Transcriptase
Chain Termination
Require Phosphorylation
1 min
Focal Segmental Glomerulosclerosis
Most Common Cause of Nephrotic Syndrome in Hispanics and African Americans
Associated with Sickle Cell Disease and HIV
Associated Interferon Therapy and Heroin Abuse
Histopathology
LM Segmental Sclerosis and Hyalinosis
EM Focal Damage of Visceral Epithelial Cells
IF Negative
Signs & Symptoms
Microscopic Hematuria
Nonselective Proteinuria
Considerations
Poor Prognosis
2 mins
Protease Inhibitors
End in "-navir"
Indications
HIV/AIDS
Hepatitis C
Mechanism
Inhibit Protease
Unable to Cleave Proteins
Inhibits Maturation of New Virus
Side Effects
GI Distress
Nephropathy
Lipodystrophy
Hyperglycemia
3 mins
Integrase Inhibitors
-gravir Suffix
Indications
HIV
Mechanism
Blocks Insertion of Viral Genome
Inhibit Actions of Integrase
Side Effects
Hypercholesterolemia
Increased LFT's
Insomnia
Increased Creatine Kinase (CK)
1 min
Bacteroides Fragilis
Characteristics
Gram-Negative
Anaerobe
Normal Colonic Flora
Produces Vitamin K
Produces Gas in Tissue
Foul-Smelling
Signs and Symptoms
Gastrointestinal Abscess
Treatment
Penicillin-Resistant
Clindamycin
Metronidazole
2 mins
Bordetella pertussis
Pathophysiology
Gram-Negative
Coccobacillus
Bordet-Gengou Agar
ADP Ribosylating AB Toxin
Inhibits Gi to cause Increase in cAMP
Signs AND Symptoms
Lymphocytosis
Increase in Insulin
Catarrhal Phase is Infectious Period
Paroxysmal Phase is Symptomatic Period
Whooping Cough
Treatment
Macrolides
4 mins
Staphylococcus aureus Disease
Skin Infections
Impetigo
Abscesses
Exfoliative Toxin
Scalded Skin Syndrome
Toxic Shock Syndrome (TSST 1)
Binds to MHC II and T Cell Receptor
Food Poisoning
Acute Bacterial Endocarditis
Pneumonia
Osteomyelitis
2 mins
Staphylococcus saprophyticus
Characteristics
Gram-Positive
Cocci
Catalase-Positive
Coagulase-Negative
Novobiocin-Resistant
Urease-Positive
Disease
Urinary Tract Infections (UTI's)
1 min
Staphylococcus aureus Characteristics
Characteristics
Gram-Positive
Cocci
Catalase-Positive
Coagulase-Positive
Beta-Hemolytic
Protein A Virulence Factor
Inhibits Phagocytosis
MRSA
Resistant to Beta Lactams Due to Altered Penicillin Binding Proteins (PBPs)
2 mins
Staphylococcus epidermidis
Characteristics
Cocci
Gram-Positive
Catalase-Positive
Urease-Positive
Coagulase-Negative
Novobiocin-Sensitive
Component of Normal Skin Flora
Infects Prosthetic Devices and IV Catheters
Contaminates Blood Cultures
Produces Adherent Biofilms
2 mins

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