Ashton Shared "RSM - Pulmonary Pharmacology Midterm" - 85 Picmonics

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RSM - Pulmonary Pharmacology Midterm

Asthma
Obstructive lung disease
Bronchial Hyperresponsiveness
History of Atopic Disease
Beta2 agonists
Corticosteroids
Curschmann's spirals
Hypertrophy of smooth muscle
Reversible
Charcot Leyden crystals
Methacholine challenge
Wheezing
Cough
Initially decreased PaCO2
Pulsus paradoxus
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2 mins
Intermittent Asthma
Diagnosis
Symptoms (Bronchoconstriction) and Rescue Inhaler Use ≤ 2 / Week
No Interference With ADLs
Nighttime Awakening < 2 / Month
> 80 % of Predicted FEV1
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1 min
Persistent Mild Asthma
Diagnosis
Symptoms (Brochoconstriction) and Rescue Inhaler Use > 2 Days / Week
Nighttime Awakening 3-4 / Month
Greater or equal to 80 % of Predicted FEV1
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1 min
Persistent Moderate Asthma
Diagnosis
Symptoms (Bronchoconstriction) and Rescue Inhaler Use Daily
Nighttime Awakening > 1 / Week
60-80% Predicted FEV1
FEV1/FVC Decreased 5%
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2 mins
Persistent Severe Asthma
Diagnosis
Symptoms (Bronchoconstriction) and Rescue Inhaler Use: Multiple/ Day
With Minimal Activity
Nighttime Awakening: Nightly
< 60% Predicted FEV1
> 5% Decrease FEV1/FVC
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2 mins
Stages of Asthma Treatments
Intermittent Asthma
Short-acting Inhaled Beta-Agonist
Persistent Mild Asthma
Low-Dose Inhaled Corticosteroid
Montelukast (Leukotriene Receptor Antagonist)
Cromolyn (Mast Cell Stabilizers)
Theophylline
Persistent Moderate Asthma
Long-acting Inhaled Beta-Agonist
Zileuton
Low-Medium Dose Inhaled Corticosteroid
Persistent Severe Asthma
High-Dose Inhaled Corticosteroid
Omalizumab (Allergies)
Systemic Corticosteroids
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3 mins
Beta-2 Receptor
Characteristics
Gs protein class
Increased Heart Rate
Increased Contractility
Increased Lipolysis
Increased Insulin
Increased Aqueous Humor Production
Ciliary Muscle Relaxation
Vasodilation
Bronchodilation
Decrease Uterine Tone
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2 mins
Beta-2 Agonists
Short-term Treatment
Terbutaline
Asthma
Tocolysis
Albuterol
Asthma
Long-term Treatment
Salmeterol
Asthma
Chronic Obstructive Pulmonary Disease (COPD)
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3 mins
Albuterol (Proventil)
Mechanism
Short-Acting Beta-2 Agonist
Indications
Bronchospasm
Asthma
Side Effects
Angina
Tachycardia
Tremor
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1 min
Terbutaline (Brethine)
Mechanism of Action
Beta-2 Agonists
Indications
Asthma
Tocolytic
Side Effects
Hypotension
Tremor
Tachycardia
Pulmonary Edema
Hyperglycemia
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2 mins
Inhaled Corticosteroids
High Potency (Budesonide & Fluticasone)
Budesonide
Fluticasone
Beclamethasone
Mometasone
Flunisolide
Side Effects
Significant first pass metabolism (minimal systemic effects)
Candida albicans (Oral Thrush)
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Prednisone (Glucocorticoids)
Mechanism
Glucocorticoid
Indications
Inflammatory Conditions
Organ Transplant Rejection
Side Effects
Cataracts and Glaucoma
Cushing's Syndrome
Osteoporosis
Immunosuppression
Hyperglycemia
Ulcers
Considerations
Adrenal Insufficiency
Taper Gradually
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2 mins
Montelukast (Singulair)
Mechanism
Leukotriene Receptor Blocker
Indications
Allergic Rhinitis
Asthma Prophylaxis
Exercise Induced Bronchospasm
Side Effects
Fatigue
Headache
Mood Changes
Suicidal Thoughts
Considerations
Increased Risk of Churg Strauss
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2 mins
Anticholinergics Continued
Drugs
Glycopyrrolate
Reduces Airway Secretions
Ulcer Treatment
Ipratropium
Asthma and C.O.P.D
Dicyclomine
Hyoscyamine
Irritable Bowel Syndrome
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1 min
Theophylline
Indications
Asthma
Mechanism
Inhibits Phosphodiesterase
Increases cAMP
Side Effects
Cardiotoxicity
Neurotoxicity
Blocks Adenosine Action
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53 secs
Penicillin
Gram Positive
Spirochetes
Bind PBPs
Block Transpeptidase Cross-linking of Cell Wall
Activate Autolytic Enzymes
Bactericidal
Hypersensitivity Reactions
Hemolytic Anemia
Beta-lactamase Sensitive
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2 mins
Streptococcus Pneumoniae Disease
Signs and Symptoms
Sickle Cell Anemia
Sepsis in Patients with Splenectomy
Rusty Sputum
MOPS
Meningitis
Otitis Media
Pneumonia
Sinusitis
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2 mins
Streptococcus Pneumoniae Characteristics
Characteristics
Gram-Positive
Diplococci
Lancet-Shaped
Catalase-Negative
Optochin-Sensitive
Bile Soluble
Alpha-Hemolytic
Polysaccharide Capsule
Positive Quellung Reaction
IgA Protease
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1 min
Streptococcus Pyogenes Disease
Pyogenic
Pyogenic
Pyogenic Pharyngitis
Impetigo
Cellulitis
Toxigenic
Toxic Shock-Like Syndrome
Scarlet Fever
Sandpaper Rash
Strawberry Tongue
Immunologic
Immunologic
Rheumatic Fever
Antibodies to M Protein
Acute Glomerulonephritis (Post Streptococcal Glomerulonephritis)
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2 mins
Streptococcus pyogenes Characteristics
Characteristics
Group A Streptococci (GAS)
Gram-Positive
Cocci
Beta-Hemolytic
Catalase-Negative
Bacitracin-Sensitive
Hyaluronic Acid Capsule
Streptolysin O
DNase
Streptokinase
Exotoxin A
Pyrrolidonyl Arylamidase (PYR) Positive
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2 mins

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