Ashton Shared "RSM - Pulmonary Pharmacology Midterm" - 85 Picmonics
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RSM - Pulmonary Pharmacology Midterm
Asthma
- Obstructive lung disease
- Bronchial Hyperresponsiveness
- History of Atopic Disease
- Beta2 agonists
- Corticosteroids
- Curschmann's spirals
- Hypertrophy of smooth muscle
- Reversible
- Charcot Leyden crystals
- Methacholine challenge
- Wheezing
- Cough
- Initially decreased PaCO2
- Pulsus paradoxus
2 mins
Intermittent Asthma
- Diagnosis
- Symptoms (Bronchoconstriction) and Rescue Inhaler Use ≤ 2 / Week
- No Interference With ADLs
- Nighttime Awakening < 2 / Month
- > 80 % of Predicted FEV1
1 min
Persistent Mild Asthma
- Diagnosis
- Symptoms (Brochoconstriction) and Rescue Inhaler Use > 2 Days / Week
- Nighttime Awakening 3-4 / Month
- Greater or equal to 80 % of Predicted FEV1
1 min
Persistent Moderate Asthma
- Diagnosis
- Symptoms (Bronchoconstriction) and Rescue Inhaler Use Daily
- Nighttime Awakening > 1 / Week
- 60-80% Predicted FEV1
- FEV1/FVC Decreased 5%
2 mins
Persistent Severe Asthma
- Diagnosis
- Symptoms (Bronchoconstriction) and Rescue Inhaler Use: Multiple/ Day
- With Minimal Activity
- Nighttime Awakening: Nightly
- < 60% Predicted FEV1
- > 5% Decrease FEV1/FVC
2 mins
Stages of Asthma Treatments
- Mild Intermittent
- Short-acting Inhaled Beta-Agonist
- Mild Persistent
- Low-Dose Inhaled Corticosteroid
- Montelukast (Leukotriene Receptor Antagonist)
- Moderate Persistent
- Low to Medium-dose Inhaled Corticosteroid
- Zileuton
- Severe Persistent
- High-Dose Inhaled Corticosteroid
- Systemic Corticosteroids
- Omalizumab (Allergies)
2 mins
Beta-2 Receptor
- Characteristics
- Gs Protein Class
- Cardiopulmonary
- Increased Heart Rate
- Increased Contractility
- Bronchodilation
- Metabolic
- Increased Lipolysis
- Increased Insulin
- Increased Glycogenolysis
- Increased Cellular Potassium Uptake
- Considerations
- Increased Aqueous Humor Production
- Vasodilation
- Decrease Uterine Tone
2 mins
Beta-2 Agonists
- Short-term Treatment
- Terbutaline
- Asthma
- Tocolysis
- Albuterol
- Asthma
- Long-term Treatment
- Salmeterol
- Asthma
- Chronic Obstructive Pulmonary Disease (COPD)
3 mins
Albuterol (Proventil)
- Mechanism
- Short-Acting Beta-2 Agonist
- Indications
- Bronchospasm
- Asthma
- Side Effects
- Angina
- Tachycardia
- Tremor
1 min
Terbutaline (Brethine)
- Mechanism of Action
- Beta-2 Agonists
- Indications
- Asthma
- Tocolytic
- Side Effects
- Hypotension
- Tremor
- Tachycardia
- Pulmonary Edema
- Hyperglycemia
2 mins
Inhaled Corticosteroids
- High Potency (Budesonide & Fluticasone)
- Budesonide
- Fluticasone
- Beclamethasone
- Mometasone
- Flunisolide
- Side Effects
- Significant first pass metabolism (minimal systemic effects)
- Candida albicans (Oral Thrush)
Prednisone (Glucocorticoids)
- Mechanism
- Glucocorticoid
- Indications
- Inflammatory Conditions
- Organ Transplant Rejection
- Side Effects
- Cataracts and Glaucoma
- Cushing's Syndrome
- Osteoporosis
- Immunosuppression
- Hyperglycemia
- Ulcers
- Considerations
- Adrenal Insufficiency
- Taper Gradually
2 mins
Montelukast (Singulair)
- Mechanism
- Leukotriene Receptor Blocker
- Indications
- Allergic Rhinitis
- Asthma Prophylaxis
- Exercise Induced Bronchospasm
- Side Effects
- Fatigue
- Headache
- Mood Changes
- Suicidal Thoughts
- Considerations
- Increased Risk of Churg Strauss
2 mins
Anticholinergics Continued
- Drugs
- Glycopyrrolate
- Reduces Airway Secretions
- Ulcer Treatment
- Ipratropium
- Asthma and C.O.P.D
- Dicyclomine
- Hyoscyamine
- Irritable Bowel Syndrome
1 min
Theophylline
- Indications
- Asthma
- Mechanism
- Inhibits Phosphodiesterase
- Increases cAMP
- Side Effects
- Cardiotoxicity
- Neurotoxicity
- Blocks Adenosine Action
53 secs
Penicillin
- Gram Positive
- Spirochetes
- Bind PBPs
- Block Transpeptidase Cross-linking of Cell Wall
- Activate Autolytic Enzymes
- Bactericidal
- Hypersensitivity Reactions
- Hemolytic Anemia
- Beta-lactamase Sensitive
2 mins
Streptococcus Pneumoniae Disease
- Signs and Symptoms
- Sickle Cell Anemia
- Sepsis in Patients with Splenectomy
- Rusty Sputum
- MOPS
- Meningitis
- Otitis Media
- Pneumonia
- Sinusitis
2 mins
Streptococcus Pneumoniae Characteristics
- Characteristics
- Gram-Positive
- Diplococci
- Lancet-Shaped
- Catalase-Negative
- Optochin-Sensitive
- Bile Soluble
- Alpha-Hemolytic
- Polysaccharide Capsule
- Positive Quellung Reaction
- IgA Protease
1 min
Streptococcus Pyogenes Disease
- Pyogenic
- Pyogenic
- Pyogenic Pharyngitis
- Impetigo
- Cellulitis
- Toxigenic
- Toxic Shock-Like Syndrome
- Scarlet Fever
- Sandpaper Rash
- Strawberry Tongue
- Immunologic
- Immunologic
- Rheumatic Fever
- Antibodies to M Protein
- Acute Glomerulonephritis (Post Streptococcal Glomerulonephritis)
2 mins
Streptococcus pyogenes Characteristics
- Characteristics
- Group A Streptococci (GAS)
- Gram-Positive
- Cocci
- Beta-Hemolytic
- Catalase-Negative
- Bacitracin-Sensitive
- Hyaluronic Acid Capsule
- Streptolysin O
- DNase
- Streptokinase
- Exotoxin A
- Pyrrolidonyl Arylamidase (PYR) Positive
2 mins
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