OnlineMedEd Shared "General Physiology - Cytoskeleton" - 5 Picmonics

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General Physiology - Cytoskeleton

Metaphase
Characteristics
Microtubules Extend from Centrioles' Spindles
Centromere
Kinetochore
Meiosis I Tetrads Aligned at Metaphase Plate
Meiosis II Sister Chromatids Aligned at Metaphase Plate
Mitosis Sister Chromatids Aligned at Metaphase Plate
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57 secs
Vincristine (Oncovin)
Mechanism
Vinca Alkaloid
Inhibits Microtubules
Indications
Leukemias
Lymphomas
Side Effects
Peripheral Neuropathy
Paralytic Ileus
Considerations
Vesicant
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2 mins
Skeletal Muscle Contraction Action
Characteristics
Calcium Binds Troponin
Active Site Exposed
Many Mitochondria Produce ATP
Myosin Head Binds
Power Stroke
Myosin Head Releases Active Site
ATP Consumed
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1 min
Skeletal Muscle Contraction Initiation
Somatic Motor Neuron Releases Acetylcholine
Acetylcholine Causes Sodium Influx
Cell Reaches All-or-Nothing Threshold
Voltage-Gated Calcium Channels Open
Sarcoplasmic Reticulum Causes Calcium Flood
Calcium Flood Enters Myofibrils
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1 min
Hereditary Spherocytosis Disease
Northern Europeans
Mechanisms
Autosomal Dominant
Spectrin/Ankyrin Deficiency
Spherocyte Formation
Hemolytic Anemia
Symptoms
Bilirubin Gallstones
Jaundice
Splenomegaly
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3 mins

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