Josiah Shared "Pharm" - 66 Picmonics
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Pharm
Competitive Inhibition
- Reversible Inhibition
- Constant Vmax
- Substrate Competes With Inhibitor For The Active Site
- Inhibition Increases Km
1 min
Non-Competitive Inhibition
- Characteristics
- Reversible Inhibition
- Substrate Freely Binds The Active Site
- Inhibitor Strongly Binds Allosteric Site
- Km Constant
- Enzyme Has Different Conformational Form
- Low Vmax
2 mins
Arsenic, Gold and Copper Antidotes
- Toxic Metals
- Arsenic
- Gold
- Copper
- Antidotes
- Penicillamine
- Dimercaprol (BAL)
- Succimer
2 mins
Acetaminophen
- Indications
- Fever
- Pain
- Mechanism of Action
- Reversibly Inhibits COX
- Acts Primarily in CNS
- Side Effect
- Hepatic Necrosis
- N-acetylcysteine Antidote
51 secs
Acetaminophen Antidote
- Antidote
- N-Acetylcysteine
33 secs
Acetylcholinesterase Inhibitor Poisoning
- DUMBBELSS
- Diarrhea
- Urination
- Miosis
- Bronchospasm
- Bradycardia
- Emesis
- Lacrimation
- Salivation
- Sweating
2 mins
Acetylcholinesterase Inhibitor Antidote
- Antidote
- Atropine
- Pralidoxime
1 min
Atropine
- Indications
- Blocks DUMBBeLSS
- Bradycardia
- Side Effects
- Skin Flushing
- Increased Temperature
- Dry Mouth
- Cycloplegia
- Disorientation
- Mydriasis
1 min
Antimuscarinic Antidote
- Antidote
- Physostigmine Salicylate
44 secs
Benzodiazepines Overview
- Indications
- First Line for Status Epilepticus
- Anesthesia Induction
- Anxiety
- Eclampsia
- Detoxification
- Mechanism of Action
- '-zepam' and '-zolam" Suffix
- Increase Frequency of Cl- Channel Opening
- Side Effects
- Decrease REM Sleep
- CNS Depression
- Dependence
- Antidote
- Flumazenil for Overdose
2 mins
Iron Antidote
- Antidote
- DeFEroxamine
23 secs
Lead Antidotes
- Antidotes
- Dimercaprol
- CaEDTA
- Succimer
39 secs
Opioid Antidote
- Antidote
- Naloxone
29 secs
Aspirin Poisoning (Salicylism) Assessment
- Early Symptoms
- Nausea and Vomiting
- Tinnitus
- Confusion
- Hyperventilation
- Respiratory Alkalosis
- Late Symptoms
- Metabolic Acidosis
- Coma
- Hyperthermia
1 min
Warfarin
- Mechanism of Action
- Interferes with Vitamin K-dependent Clotting Factors
- Extrinsic Pathway
- Bridge with Heparin
- Indications
- Chronic Anticoagulation
- Side Effects
- Bleeding
- Necrosis
- Cytochrome P450
- Contraindications
- Pregnancy
- Antidote
- FFP + Vitamin K
2 mins
Warfarin Antidotes
- Antidotes
- Vitamin K
- Fresh Frozen Plasma
59 secs
P450 Inducer
- Griseofulvin
- Phenytoin
- Carbamazepine
- Rifampin
- Barbiturates
- Chronic Alcohol Use
- St. John's Wort
51 secs
P450 Inhibitors
- Quinidine
- Ciprofloxacin
- Isoniazid
- Grapefruit Juice
- Acute Alcohol Use
- Erythromycin (Macrolide)
- Indinavir
- Cimetidine
- Sulfonamides
- Ketoconazole
- Amiodarone
2 mins
Sulfonamides Mechanisms
- Bacteriostatic
- Gram-Positive
- Gram-Negative
- Nocardia
- Chlamydia
- PABA antimetabolites
- Inhibit dihydropteroate synthase
- Sulfamethoxazole
- Sulfisoxazole
- Sulfadiazine
1 min
Sulfonamides Side Effects
- Side Effects
- Hypersensitivity
- Nephrotoxicity
- Photosensitivity
- Kernicterus in Infants
- Displaces Warfarin from Albumin
- Considerations
- Hemolysis with G6PD Deficiency
3 mins
