Shannon Shared "Pharm IV Exam II" - 24 Picmonics
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Pharm IV Exam II
Oxytocin (Pitocin)
- Mechanism of Action
- Increase Uterine Contractions
- Indications
- Labor Induction
- Control Postpartum Hemorrhage
- Side Effects
- Uterine Rupture
- Water Intoxication
- Contraindications
- Fetal Lung Immaturity
- Cervix Not Ripened
- Active Genital Herpes Infection
- Considerations
- Use Lowest Dose
- IV Pump
3 mins
Dinoprostone and Misoprostol
- Mechanism
- Prostaglandins
- Indications
- Promote Cervical Ripening
- Prevent GI Ulcers
- Medical Abortion
- Side Effects
- Fetal Distress
- Hyperstimulation of Uterus
- Considerations
- Vaginal Insertion
- Give Before Induction of Labor
2 mins
Terbutaline (Brethine)
- Mechanism of Action
- Beta-2 Agonists
- Indications
- Asthma
- Tocolytic
- Side Effects
- Tremor
- Tachycardia
- Pulmonary Edema
- Hypokalemia
- Hyperglycemia
2 mins
Tocolytics
- Calcium Channel Blockers
- Magnesium Sulfate (MgSO4)
- Contraindicated in Myasthenia Gravis
- Nifedipine
- NSAIDs
- Indomethacin
- Safe in Second Trimester Only
- Blocks Prostaglandin F2-alpha Analog
- Beta 2 Agonist
- Increases cAMP
- Hypokalemia, Hyperglycemia
- Salbutamol
- Terbutaline
- Ritodrine
- Atosiban
Butorphanol
- Indications
- Migraine
- Severe Pain
- Labor
- Mechanism of Action
- Partial Agonist at Mu and Full Agonist at Kappa Receptors
- Less Respiratory Depression
- Side Effects
- Withdrawal Symptoms
1 min
Methylergonovine (Methergine) and Ergotamine (Ergot Alkaloids)
- Mechanism
- Smooth Muscle Contraction
- Vasoconstriction
- Indications
- Migraine
- Postpartum Hemorrhage
- Side Effects
- Nausea and Vomiting
- Severe Hypertension
- Tachycardia
- Considerations
- 2nd Line Agent
2 mins
Carboprost (Hemabate)
- Mechanism
- Prostaglandin F2-alpha Analog
- Smooth Muscle Contraction
- Indications
- Postpartum Hemorrhage
- Abortion
- Side Effects
- GI Distress
- Hypertension
- Fever
- Bronchoconstriction
- Considerations
- Identify Cause of Fever
2 mins
Donepezil
- Indications
- Alzheimer's Disease
- Mechanism of Action
- Acetylcholinesterase Inhibitor
- Increased Acetylcholine
- Side Effects
- Nausea and Vomiting
- Dizziness
52 secs
Iron (Ferrous Sulfate)
- Mechanism
- Ferrous Salts
- Indications
- Anemia
- Side Effects
- GI Distress
- Nausea and Vomiting
- Dark Stools
- Considerations
- Take Between Meals
- Liquid can Stain Teeth
- Keep out of Reach from Children
- Caution with GI Disorders
- Avoid Antacids
3 mins
Vitamin B12 (Cobalamin) Mechanism and Deficiency
- Mechanism
- Cobalamin
- Large reserve pool in the liver
- Homocysteine to methionine
- Methylmalonyl CoA to succinyl CoA
- Deficiency Signs and Symptoms
- Macrocytic Megaloblastic Anemia
- Hypersegmented Neutrophils
- Neurologic defects
- Posterior column
- Lateral corticospinal tract
- Spinocerebellar tract
5 mins
Erythropoietin
- Mechanism
- Stimulates RBC Production
- Indications
- Chronic Renal Failure
- Anemia
- Side Effects
- Increased Risk of Thrombosis
- Pelvic and Limb Pain
- Hypertension
- Considerations
- Do Not Shake
- Monitor Hemoglobin (Hgb) Weekly
- May Accelerate Tumor Progression
2 mins
Heparin Indications
- Indications
- Acute Coronary Syndrome (ACS)
- Prophylaxis
- Pulmonary Embolism
- Atrial Fibrillation
- Used during Pregnancy
1 min
Heparin Mechanisms
- Mechanism of Action
- Short Half-life
- Antithrombin Activation Cofactor
- Decrease Thrombin, Factor Xa
- Side Effects
- Bleeding
- Heparin Induced Thrombocytopenia (HIT)
- Antidote
- Protamine Sulfate
2 mins
Heparin Induced Thrombocytopenia (HIT)
- Pathophysiology
- 5-10 Days After Heparin Exposure
- Heparin-Platelet Factor 4 Complex
- Autoantibodies Form Against Complex
- Heparin-Platelet Factor 4-Antibody Complex Binds Platelets
- Platelet Aggregation
- Procoagulant Release
- Symptoms
- Thrombocytopenia
- Diagnosis
- Serotonin Release Assay (SRA)
- Treatment
- Stop Heparin, Start Direct Thrombin Inhibitor
2 mins
Warfarin
- Mechanism of Action
- Interferes with Vitamin K-dependent Clotting Factors
- Extrinsic Pathway
- Bridge with Heparin
- Indications
- Chronic Anticoagulation
- Side Effects
- Bleeding
- Necrosis
- Cytochrome P450
- Contraindications
- Pregnancy
- Antidote
- FFP + Vitamin K
2 mins
Warfarin Antidotes
- Antidotes
- Vitamin K
- Fresh Frozen Plasma
59 secs
INR Lab Value
- 0.8-1.2 Normal Range
- Warfarin
- 2.0-3.0
1 min
Factor Xa Inhibitors
- Characteristics
- Inhibit Factor Xa
- -xaban
- Drugs
- Apixaban
- Rivaroxaban
- Indications
- Pulmonary Embolism
- Nonvalvular Atrial Fibrillation
- Deep Vein Thrombosis
- Considerations
- Andexanet Alfa
2 mins
Alteplase
- Mechanism
- Tissue Plasminogen Activator
- Indications
- Thrombosis
- Side Effects
- Bleeding
- Contraindications
- Intracranial Hemorrhage
- Internal Hemorrhaging
- Considerations
- Minimize Bleeding
- Monitor for Shock
- Antidote
- Aminocaproic Acid
2 mins
Aspirin
- Indications
- Fever
- Pain and Headache
- Cardiovascular Disease (CAD)
- Mechanism of Action
- Irreversible inhibition of COX-1 and COX-2
- Suppress Thromboxanes and Prostaglandins
- NSAID
- Side Effects
- Reye's Syndrome
- Tinnitus
- Peptic Ulceration
- Mixed Acidosis/Alkalosis
- Nephropathy
2 mins
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