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SBM - Week 2 Muscles
Opioids Overview
Indications
Pain
Weaning
Cough
Diarrhea
Mechanism of Action
Agonists at Mu (μ), Kappa (Κ), and Delta (δ) Receptors
Decrease Synaptic Transmission
Side Effects
Respiratory Depression
Addiction
Miosis
Constipation
2 mins
Opioid Antidote
Antidote
Naloxone
29 secs
Tramadol
Indications
Chronic Pain
Mechanism of Action
Weak Opioid
Inhibit Serotonin and NE reuptake
Side Effect
Increased Risk of Seizure
48 secs
IV Anesthetics
Barbiturates
Benzodiazepines
Respiratory Depression
Hypotension
Ketamine
NMDA Receptor Antagonist
Hallucinations
Opioids
Propofol
Potentiates GABA-A
2 mins
Respiratory Acidosis
Hypoventilation
Increased PaCO2 > 45
Barbiturates Depress Central Respiratory Center of Brain
Opioids Depress Central Respiratory Center of the Brain
Airway Obstruction
Respiratory Muscle Weakness/Paralysis
3 mins
Clostridium botulinum
Characteristics
Bacillus
Gram-positive
Anaerobe
Spore-forming
Heat Labile Toxin
Inhibits Acetylcholine (Ach) Release at Neuromuscular Junction (NMJ)
Canned Food in Adults
Spores in Honey
Signs and Symptoms
Descending Flaccid Paralysis
Diplopia
Ptosis
Floppy Baby
Constipation
2 mins
Myasthenia Gravis
Mechanism
Antibodies to Acetylcholine Receptor
Symptoms
Ptosis
Diplopia
Weakness with Muscle Use
Respiratory Death
Thymus Associated
Treatment
Acetylcholinesterase Inhibitors
Plasmapheresis
Thymectomy
1 min
Myotonic Dystrophy
Pathophysiology
Autosomal Dominant
Trinucleotide Repeat
CTG
Signs and Symptoms
Facial Muscle Weakness
Frontal Balding
Sustained Grip
Conduction Defects
Cataracts
Selective Atrophy of Type 1 Fibers
Testicular Atrophy
2 mins
Chemical Synapse
Voltage-Gated Calcium Channels Open
Ca2+ Influx
Vesicle-Membrane Fusion
Exocytosis of Neurotransmitter
Neurotransmitter Binds Post-Synaptic Receptors
Neurotransmitter Breakdown
Neurotransmitter Reuptake
1 min
Ankylosing Spondylitis
Chronic Inflammatory Arthritis
"Bamboo Spine"
HLA-B27
Uveitis
Aortic Regurgitation
1 min
Leg Arteries
Descending Aorta
Iliac (Ilium)
Common Femoral
Deep Femoral
Superficial Femoral
Popliteal
Anterior Tibial
Posterior Tibial
Peroneal
Dorsalis Pedis
2 mins
Leg Veins
Inferior Vena Cava
Common Iliac (Ilium)
External Iliac (Ilium)
Great Saphenous
Femoral
Popliteal
Small Saphenous
Anterior Tibial
Posterior Tibial
1 min
Leg Nerves
Femoral
Saphenous
Posterior Femoral Cutaneous
Sciatic
Tibial
Common Peroneal
Superficial Peroneal
Deep Peroneal
1 min
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