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Nathan Shared "MSK Pain/Inflamm Pharm Exam 2" - 6 Picmonics

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MSK Pain/Inflamm Pharm Exam 2

Methotrexate
Indications
Rheumatoid Arthritis
Cancer
Medical Abortion
Mechanism
Folic Acid Analog
Inhibits Dihydrofolate Reductase
Side Effects
Pulmonary Fibrosis
Myelosuppression is Treated with Leucovorin Rescue (Folinic Acid)
Macrocytic Anemia
Hepatitis
Teratogenic
Mucositis
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2 mins
Leflunomide
Use And Mechanism
Immunosuppressant Used In Rheumatoid Arthritis
DMARD
Inhibits Dihydroorotate Dehydrogenase
Blocks Pyrimidine Synthesis And T-Cell Proliferation
Adverse Effects
Hepatotoxicity
Bone Marrow Suppression
GI Upset
Alopecia
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4 mins
Hydroxychloroquine
Mechanism of Action
Immunosuppressant
Indications
Malaria
Rheumatoid Arthritis
Systemic Lupus Erythematosus (SLE)
Porphyria Cutanea Tarda
Side Effects
Cardiotoxicity
Retinopathy
Considerations
Ophthalmological Exams
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3 mins
TNF-Alpha Inhibitor Drugs and Complications
Etanercept
Decoy TNF- Alpha receptor
Anti-TNF- Alpha antibody
Adalimumab
Infliximab
Complications
Increased risk of infection
Predispose to Tuberculosis (TB) reactivation
Order Baseline PPD- skin test
Quantiferon Gold In-Tube
Order Chest X-Ray
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2 mins
Gout Treatment
Acute (Acute-angle)
NSAIDs
Glucocorticoids
Colchicine
Impairs Leukocyte Chemotaxis
Chronic Gout (Crone Goat)
Inhibit Xanthine Oxidase
Allopurinol
Febuxostat
Inhibit Reabsorption of Uric Acid
Probenecid
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1 min
Pegloticase
Characteristics
Recombinant Uricase
Converts Uric Acid to Allantoin
3rd Line Agent
Indications
Chronic Gout
Considerations
Infusion Reactions
Contraindicated in G6PD Deficiency
Gout Flares
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2 mins

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