Amy Shared "Thyroid and Antithyroid drugs" - 4 Picmonics

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Thyroid and Antithyroid drugs

Levothyroxine
Indications
Hypothyroidism
Myxedema Coma
Mechanism of Action
Isomer of thyroid hormone (T4)
T3 has higher potency
Side Effects
Hyperthyroid symptoms
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56 secs
Propylthiouracil (PTU) and Methimazole (MMI)
Indications
Hyperthyroidism
Mechanism
Inhibits Thyroid Peroxidase
PTU Blocks Peripheral Conversion of T4 to T3
Side Effects
Agranulocytosis
Skin Rash
Hepatotoxicity (PTU)
Teratogen (MMI)
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1 min
Hyperthyroidism Interventions
Drug Therapy
Propylthiouracil (PTU)
Methimazole (Tapazole)
Iodine
Beta Blockers
Other Therapies
Radioiodine Ablation
Thyroidectomy
Complications
Thyrotoxicosis
Post-Surgery Hypocalcemia
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2 mins
Thyroid Storm
Symptoms
Diarrhea
Liver Failure
Insulin Resistance
Tachycardia
Lid lag
Change in LOC (Altered Mental Status)
High fever
Treatment
Propranolol (Or Esmolol)
PTU (Thionamides) Initially
Iodine Solution (Lugol Iodine)
Glucocorticoids
Cooling Blanket
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3 mins

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