Ken Shared "Chris's Pharm course" - 252 Picmonics

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Chris's Pharm course

Benztropine (Cogentin)
Mechanism
Anticholinergic
Indications
Parkinson's Disease
Acute Dystonia
Side Effects
Blurred Vision
Dry Mouth
Urinary Retention
Tachycardia
Constipation
Psychosis
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2 mins
Indirect Cholinomimetics
Acetylcholinesterase Inhibitors
Doesn't Cross BBB
Edrophonium
Myasthenia Gravis (Diagnosis)
Pyridostigmine and Neostigmine
Myasthenia Gravis (Tx)
Ileus
Crosses BBB
Physostigmine
Atropine Overdose
Glaucoma
Donepezil
Alzheimer's
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2 mins
Benzodiazepine Antidote
Antidote
Flumazenil
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39 secs
Alpha 2 Receptor
Characteristics
Gi subunit
Decrease Sympathetic Outflow
Decrease Insulin Release
Decrease Lipolysis
Increase Platelet Aggregation
Decrease Aqueous Humor Production
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2 mins
Selective Beta-1 Blockers
Characteristics
"-olol" Suffix
Drug Names
Beta-1 selective
Atenolol
Esmolol
Metoprolol
Partial Beta agonists
Acebutolol
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1 min
Nonselective Beta-Blockers
"-olol" Suffix
Nonselective
Propranolol
Timolol
Nadolol
Partial β Agonist
Pindolol
Nonselective β with α Blocking
Carvedilol
Labetalol
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2 mins
Systemic Effects of Beta-Blockers
Respiratory
Bronchoconstriction
Metabolic
Decreased Insulin
Decreased Glycolysis and Lipolysis
Eye
Reduces Intraocular Pressure
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1 min
Cardiovascular Effects of Beta-Blockers
Cardiac Myocytes and Vasculature
Decrease cAMP
Decreases SA and AV Node Conduction Velocity
Lower Blood Pressure
Decrease O2 Consumption
Decreases Mortality Post-MI
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2 mins
Selective Alpha-1 Blockers
"-osin" suffix
Mechanism of Action
Blocks Alpha1 Receptors
Indications
Hypertension
Benign Prostatic Hyperplasia (BPH)
Side Effects
Syncope
Orthostatic Hypotension
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1 min
Prazosin (Minipress)
-osin suffix
Mechanisms
Selective Alpha-1 Receptor Blocker
Indications
Hypertension
Benign Prostatic Hyperplasia (BPH)
Nightmares
Side Effects
Orthostatic Hypotension
Tachycardia
Priapism / Inhibition of Ejaculation
Nasal Congestion
Considerations
First Dose Effect
Administer at Bedtime
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2 mins
Minoxidil (Loniten, Rogaine)
Mechanism
Vasodilates Arterioles
Indications
Severe Hypertension
Baldness
Side Effects
Reflex Tachycardia
Blood Volume Expansion
Hypertrichosis
Pericardial Effusion
Rash
Considerations
Give with Beta Blocker and Diuretic
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2 mins
Nitroprusside
Mechanism of Action
Direct Release of NO
Increase cGMP
Short Half-Life
Indications
Malignant Hypertension
Side Effect
Cyanide Toxicity
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1 min
Hydralazine
Indications
Reduce Afterload
Severe Hypertension
Safe during Pregnancy
CHF
Mechanism of Action
Increases cGMP
Vasodilates Arterioles
Side Effects
Drug-induced Lupus
Reflex Tachycardia
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1 min
Class I Antiarrhythmics (Na+ Channel Blockers) Overview
Indications
Arrhythmias
Local Anesthesia
Mechanism of Action
Block or Slow Conduction
Block Na+ Channels
Raise Threshold
State Dependent
Contraindication
Hyperkalemia
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1 min
Class IA Antiarrhythmics (Na+ Channel Blockers)
Indications
Arrhythmias
Mechanism of Action
Increase AP, ERP, and QT interval.
Drugs
Disopyramide
Procainamide
Drug-induced Lupus
Quinidine
Cinchonism
Shared Side Effects
Thrombocytopenia
Torsades de Pointes
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1 min
Class IB Antiarrhythmics (Na+ Channel Blockers)
Indications
Arrhythmias
After Myocardial Infarction
Mechanism of Action
Affect Ischemic Tissue
Decrease AP duration
Drugs
Mexiletine
GI Upset
Lidocaine
CNS Depression
Tocainide
Phenytoin
Hirsutism
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2 mins
Class IC Antiarrhythmics (Na+ Channel Blockers)
Indications
Used as Last Resort
V-Tach
Mechanism of Action
No Effect on AP Duration
Drugs
Propafenone
Flecainide
Contraindications
Post-Myocardial Infarction
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55 secs
Class III Antiarrhythmics (K+ Channel Blockers)
Indications
Arrhythmias
Mechanism of Action
Increase AP Duration, ERP, and QT Interval
Drug Names
Amiodarone
Check Function Tests
Dirty Drug
Ibutilide
Dofetilide
Sotalol
Beta-Blocker
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2 mins
Class IV Antiarrhythmics (Ca2+ Channel Blockers)
Indications
SVT
Subarachnoid Hemorrhage
Mechanism of Action
Decrease Conduction Velocity
Increase PR Interval and ERP
Drugs
Verapamil
Diltiazem
Nimodipine
Side Effects
Cardiovascular
Constipation
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2 mins
Adenosine (Adenocard)
Mechanism
Slows AV Conduction
Indications
Supraventricular Tachycardia (Paroxysmal)
Side Effects
Bradycardia
Flushing
Dyspnea
Considerations
Rapid IV Push
Caffeine and Theophylline Decrease Effectiveness
Dipyridamole May Intensify Effects
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2 mins

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