OnlineMedEd Shared "Surgery: General - Breast Cancer" - 8 Picmonics
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Surgery: General - Breast Cancer
Breast Cancer Diagnosis
- Mammography
- Ultrasound
- MRI for High Risk Patients
- Confirmed with Biopsy
- Considerations
- Lymph Node Involvement
- Receptor Positivity
- Estrogen and Progesterone Receptors
- HER-2
2 mins
Doxorubicin (Adriamycin)
- Indications
- Solid Tumors
- Lymphomas and Leukemias
- Mechanism
- Free Radical Production
- Intercalates DNA
- Prevents Double Helix from Sealing
- Side Effect
- Cardiotoxicity
- Dexrazoxane Decreases Toxicity
1 min
Cyclophosphamide
- Mechanism
- Requires Bioactivation by Liver
- Cross-links DNA
- Guanine N7 Position
- Indications
- Autoimmune Disorders
- Leukemia
- Lymphoma
- Solid Tumors
- Side Effects
- Myelosuppression
- Hemorrhagic Cystitis
- Prevent with Mesna
3 mins
Trastuzumab
- Indications
- HER-2+ Breast Cancer
- Stomach Cancer
- Mechanism
- Monoclonal Antibody Against HER-2
- Inhibition of Cellular Signaling
- Cytotoxicity
- Side effects
- Cardiotoxicity
1 min
Bevacizumab Mechanisms and Indications
- Mechanisms
- Monoclonal Antibody to VEGF
- Inhibits Angiogenesis (and Vasculogenesis)
- Indications
- Capillaries Grow CORN (CG-CORN acronym)
- Colorectal Cancer
- Glioblastoma
- Cervical Cancer
- Ovarian Cancer
- Renal Cell Carcinoma
- Non-small Cell Lung Cancer (NSCLC)
- Age-related Macular Degeneration
2 mins
Bevacizumab Side Effects
- Impaired (Delayed) Wound Healing
- Hemorrhage
- Nosebleed (Epistaxis)
- GI Perforation
- Thromboembolic Event
- Osteonecrosis of the Jaw
1 min
Tamoxifen
- Mechanism of Action
- Selective Estrogen Receptor Modulator (SERM)
- Antagonist on Breast Tissue
- Indications
- ER-positive Breast Cancer
- Side Effects
- Decreased Risk of Osteoporosis
- Increased Risk of Endometrial Cancer
- Increased Risk of Venous Thromboembolism (VTE)
1 min
Aromatase Inhibitors
- Indications
- Estrogen Receptor-positive (ER+) Breast Tumors
- Systemic Metastases
- Drugs
- Reversible, non-steroid
- Letrozole
- Anastrozole
- Irreversible, steroid
- Exemestane
- Side Effects
- Osteoporosis
- Arthritis
1 min
