OnlineMedEd Shared "Surgery: General - Breast Cancer" - 8 Picmonics

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Surgery: General - Breast Cancer

Breast Cancer Diagnosis
Mammography
Ultrasound
MRI for High Risk Patients
Confirmed with Biopsy
Considerations
Lymph Node Involvement
Receptor Positivity
Estrogen and Progesterone Receptors
HER-2
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2 mins
Doxorubicin (Adriamycin)
Indications
Solid Tumors
Lymphomas and Leukemias
Mechanism
Free Radical Production
Intercalates DNA
Prevents Double Helix from Sealing
Side Effect
Cardiotoxicity
Dexrazoxane Decreases Toxicity
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1 min
Cyclophosphamide
Mechanism
Requires Bioactivation by Liver
Cross-links DNA
Guanine N7 Position
Indications
Autoimmune Disorders
Leukemia
Lymphoma
Solid Tumors
Side Effects
Myelosuppression
Hemorrhagic Cystitis
Prevent with Mesna
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3 mins
Trastuzumab
Indications
HER-2+ Breast Cancer
Stomach cancer
Mechanism
Monoclonal antibody against HER-2
Inhibition of Cellular Signaling
Cytotoxicity
Side effects
Cardiotoxicity
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1 min
Bevacizumab Mechanisms and Indications
Mechanisms
Monoclonal Antibody to VEGF
Inhibits Angiogenesis (and Vasculogenesis)
Indications
Capillaries Grow CORN (CG-CORN acronym)
Colorectal Cancer
Glioblastoma
Cervical Cancer
Ovarian Cancer
Renal Cell Carcinoma
Non-small Cell Lung Cancer (NSCLC)
Age-related Macular Degeneration
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2 mins
Bevacizumab Side Effects
Impaired (Delayed) Wound Healing
Hemorrhage
Nosebleed (Epistaxis)
GI Perforation
Thromboembolic Event
Osteonecrosis of the Jaw
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1 min
Tamoxifen
Mechanism of Action
Selective Estrogen Receptor Modulator (SERM)
Antagonist on Breast Tissue
Indications
ER-positive Breast Cancer
Side Effects
Decreased Risk of Osteoporosis
Increased Risk of Endometrial Cancer
Increased Risk of Venous Thromboembolism (VTE)
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1 min
Aromatase Inhibitors
Indications
Estrogen Receptor-positive (ER+) Breast Tumors
Systemic Metastases
Drugs
Reversible, non-steroid
Letrozole
Anastrozole
Irreversible, steroid
Exemestane
Side Effects
Osteoporosis
Arthritis
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1 min

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