Jack Shared "CV Exam 1" - 68 Picmonics
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CV Exam 1
Warfarin
- Mechanism of Action
- Interferes with Vitamin K-dependent Clotting Factors
- Extrinsic Pathway
- Bridge with Heparin
- Indications
- Chronic Anticoagulation
- Side Effects
- Bleeding
- Necrosis
- Cytochrome P450
- Contraindications
- Pregnancy
- Antidote
- FFP + Vitamin K
2 mins
Coagulation Cascade Overview
- Secondary Hemostasis
- Intrinsic Pathway
- Partial Thromboplastin Time (PTT)
- Heparin
- Extrinsic Pathway
- Prothrombin Time (PT)
- Warfarin
- Common Pathway
- Thrombin
- Convert Fibrinogen to Fibrin
- Stabilizes the Platelet Plug
2 mins
Heparin Mechanisms
- Mechanism of Action
- Short Half-life
- Antithrombin Activation Cofactor
- Decrease Thrombin, Factor Xa
- Side Effects
- Bleeding
- Heparin Induced Thrombocytopenia (HIT)
- Antidote
- Protamine Sulfate
2 mins
Heparin Induced Thrombocytopenia (HIT)
- Pathophysiology
- 5-10 Days After Heparin Exposure
- Heparin-Platelet Factor 4 Complex
- Autoantibodies Form Against Complex
- Heparin-Platelet Factor 4-Antibody Complex Binds Platelets
- Platelet Aggregation
- Procoagulant Release
- Symptoms
- Thrombocytopenia
- Diagnosis
- Serotonin Release Assay (SRA)
- Treatment
- Stop Heparin, Start Direct Thrombin Inhibitor
2 mins
Heparin Indications
- Indications
- Acute Coronary Syndrome (ACS)
- Prophylaxis
- Pulmonary Embolism
- Atrial Fibrillation
- Used during Pregnancy
1 min
Clotting Overview
- Characteristics
- Endothelial Cells are Damaged
- Platelets Respond to Exposed Collagen and Stick
- Platelets Release Recruiting Factors
- More Platelets are Attracted
- Soluble Fibrinogen Turns to Insoluble Fibrin
- Fibrin Seals the Clot
- Clot Dissolves
- Liver Produces Clotting Factors
2 mins
Hypercholesterolemia Disease
- Risk Factors
- Diabetes
- Smoking
- Family History
- Hypertension
- HDL < 40
- Men Older than 45 Years of Age
- Women Older than 55 Years of Age
- Signs and Symptoms
- Atheromas
- Plaques in Blood Vessel Walls
- Tissue Ischemia
- Xanthomas
- Lipemia Retinalis
2 mins
Deep Vein Thrombosis (DVT) Characteristics
- Mechanism
- Virchow's Triad
- Venous Stasis
- Endothelial Damage
- Hypercoagulability
- Symptoms
- Tenderness
- Homan's Sign
- Warmth
- Redness
- Swelling
- Asymptomatic
1 min
Familial Hypercholesterolemia (Type IIa Familial Dyslipidemia)
- INHERITANCE
- Autosomal Dominant
- PATHOGENESIS
- Defective or Absent LDL Receptors
- Defective Apolipoprotein B-100 (ApoB-100)
- Lab Findings
- Increased LDL
- Decreased HDL
- Type IIb also has Increased VLDL
- Symptoms/Findings
- Accelerated Atherosclerosis
- Achilles Tendon Xanthomas
- Xanthelasma
- Corneal Arcus
4 mins
Dysbetalipoproteinemia (Type III Familial Dyslipidemia)
- INHERITANCE
- Autosomal Recessive
- PATHOGENESIS
- Defective Apolipoprotein E (Apo E)
- Lab Findings
- Increased Chylomicrons
- Increased VLDL
- Symptoms/Findings
- Premature atherosclerosis
- Tuberoeruptive xanthomas
- Palmar xanthomas
3 mins
Hypertriglyceridemia (Type IV Familial Dyslipidemia)
- INHERITANCE
- Autosomal Dominant
- pathogenesis
- Hepatic Overproduction of VLDL
- Related to Insulin Resistance
- Lab Findings
- Increased VLDL
- Increased Triglycerides (> 1000 mg/dL)
- Symptoms/Findings
- Acute Pancreatitis
- Eruptive Xanthomas
- Increased Risk for Coronary Artery Disease (CAD)
- Increased Risk of Peripheral Vascular Disease
3 mins
Hyperchylomicronemia (Type I Familial Dyslipidemia)
- INHERITANCE
- Autosomal Recessive
- PATHOGENESIS
- Lipoprotein Lipase Deficiency (LPL)
- Altered Apolipoprotein C-II (Apo C-II)
- Lab Findings
- Increased Chylomicrons
- Increased Cholesterol
- Increased Triglycerides
- Symptoms/Findings
- Pancreatitis
- Hepatosplenomegaly
- No Increased Risk for Atherosclerosis
- Eruptive/Pruritic Xanthomas
- Milky White Appearance of Blood When Drawn
3 mins
Hypercholesterolemia Treatment
- Lifestyle Modifications (Diet, Exercise, Smoking Cessation)
- Statins
- Niacin
- Ezetimibe
- Fibrates
- Bile Acid Resins
- PCSK9 Inhibitors
- Omega 3 Fatty Acids
- Screening
- Pooled Cohort Test
2 mins
Mitral Stenosis
- Characteristics
- Murmur Follows Opening Snap
- Late Diastolic Murmur
- Enhanced by Expiration
- Low-Pitched Rumbling
- Dilation of Left Atrium (LA)
- Recurrent Attacks of Rheumatic Fever
2 mins
Mitral Regurgitation
- Characteristics
- Holosystolic
- Blowing Murmur
- Loudest at Apex
- Radiates toward Axilla
- Louder by Squatting
- Hand Grip
- Expiration
1 min
Aortic Stenosis
- Characteristics
- Age-related Calcifications
- Bicuspid Aortic Valve
- Crescendo-decrescendo Murmur
- Systolic Murmur
- Ejection Murmur
- Ejection Click
- Radiates to Carotids and Apex
- Pulsus Parvus et Tardus
- Syncope
- Helmet Cells
2 mins
Rheumatic Fever
- Pathophysiology
- Pharyngeal Infection with Strep Pyogenes (Group A Strep)
- Rheumatic Heart Disease
- Signs and Symptoms
- Aschoff Bodies
- Anitschkow's Cells
- Early Death Due to Myocarditis
- Migratory Polyarthritis
- Subcutaneous Nodules
- Erythema Marginatum
- Chorea
- Diagnosis
- Elevated ESR
2 mins
Acute Pericarditis Assessment
- Pericardial Sac Inflammation
- Assessment
- Sharp Chest Pain
- Increased with Inspiration
- Pain Decreased by Leaning Forward
- Pericardial Friction Rub
- Diffuse ST-Elevation
- T Wave Inversion
- Fever
- Considerations
- May Be Asymptomatic
- Cardiac Tamponade
2 mins
Acute Pericarditis Interventions
- Interventions
- Treat Underlying Disorder
- Antibiotics
- Colchicine + NSAIDs
- Corticosteroids
- Place Patient Upright with Head of Bed at 45°
- Pericardiocentesis
- Pericardial Window
2 mins
Acute Pericarditis Causes
- Idiopathic
- Infection
- Trauma
- Cardiac
- Myocardial Infarction
- Autoimmune Diseases
- Uremia
- Tumor
- Radiation
2 mins
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