Cardiovascular Effects of Beta-Blockers
Cardiac Myocytes and Vasculature Decrease cAMP Decreases SA and AV Node Conduction Velocity Lower Blood Pressure Decrease O2 Consumption Decreases Mortality Post-MI Warfarin Antidotes
Vitamin K Fresh Frozen Plasma Heparin Induced Thrombocytopenia (HIT)
5-10 Days After Heparin Exposure Heparin-Platelet Factor 4 Complex Autoantibodies Form Against Complex Heparin-Platelet Factor 4-Antibody Complex Binds Platelets Platelet Aggregation Procoagulant Release Thrombocytopenia Serotonin Release Assay (SRA) Stop Heparin, Start Direct Thrombin Inhibitor Heparin (Unfractionated)
Suppresses Coagulation Deep Vein Thrombosis (DVT) Pulmonary Embolism Hemorrhage Heparin-Induced Thrombocytopenia (HIT) Monitor aPTT Preferred (Safe) During Pregnancy Protamine Sulfate Aspirin (Acetylsalicylic Acid)
Inhibits Platelet Aggregation NSAID Thrombotic Event Prevention General Pain Inflammatory Conditions Fever Pancytopenia GI Ulcers Bleeding Withhold Before Surgery 7-10 Days Reye's Syndrome Alteplase
Tissue Plasminogen Activator Thrombosis Bleeding Intracranial Hemorrhage Internal Hemorrhaging Minimize Bleeding Monitor for Shock Aminocaproic Acid Warfarin (Coumadin)
Inhibits Clotting Factors Atrial Fibrillation Venous Thrombosis Pulmonary Embolism PT/INR Levels Observe for Bleeding Pregnancy Vitamin K and Fresh Frozen Plasma Prolonged Therapeutic Onset Maintain Same Diet Clopidogrel (Plavix)
ADP Receptor Antagonist Prevent Platelet Aggregation Acute Coronary Syndrome (ACS) Prevention of Thrombotic Events Bleeding Thrombotic Thrombocytopenic Purpura (TTP) Pancytopenia Abdominal Pain Withhold Before Surgery Angiotensin-Converting Enzyme (ACE) Inhibitors
"-pril" Suffix Block Renin Angiotensin-Aldosterone System (RAAS) Hypertension Heart Failure Dry Non-productive Cough Hypotension Dizziness Possible Hyperkalemia Angioedema Slowly Change Position Do Not Stop Abruptly Nitroglycerin
Decreases Preload Angina Up to 3 doses q 5 mins Headache Hypotension Viagra (Sildenafil) Assess Blood Pressure Protect From Light Use Glass Bottle and Special Tubing Gloves for Applying Topically Prazosin (Minipress)
-osin suffix Selective Alpha-1 Receptor Blocker Hypertension Benign Prostatic Hyperplasia (BPH) Nightmares Orthostatic Hypotension Tachycardia Priapism / Inhibition of Ejaculation Nasal Congestion First Dose Effect Administer at Bedtime Calcium Channel Blockers (Verapamil and Diltiazem)
Slows AV Conduction Angina Pectoris Arrhythmias Essential Hypertension Bradycardia Hypotension Constipation Peripheral Edema Gingival Hyperplasia Medication Education Acute Digoxin Toxicity
Hyperkalemia Cholinergic (Nausea, Vomiting, Diarrhea) Blurry Yellow Green Vision with Halo of Light Arrhythmia Bradycardia Prolonged PR interval Decreased QT Scooping on EKG T Wave Inversion Amiodarone
Amiodarone ↑ ERP, AP duration and QT interval Class 3 Potassium Channel Blocker Also Class 1/2 effects (Lipophilic) Atrial fibrillation, Atrial Flutter, Ventricular Tachycardia Mech: Peripheral Vasodilation High dose: Ventricular Arrhythmia Low dose: maintain Sinus rhythm Fx: Blue Pigments Fx: Pulmonary Fibrosis Fx: Thyroid Disorders (40% Iodine) Fx: Bradycardia Hypo/Hyper-Thyroidism Fx: Micro-Corneal Deposits * Dronederone is analog WITHOUT Iodine Alpha-Blocker Photosensitivity Check PFT, LFT and TFT Dose: + Pulse: 150 mg IV Bolus Dose: No Pulse: 300 mg IV Bolus Loop Diuretics
Thick Ascending Limb of Loop of Henle Inhibits Na+-K+-2Cl- Sulfa Drug Furosemide Lasix Ototoxicity from Rapid Injection Gout Dehydration Hypocalcemia Hypokalemia Orthostatic Hypotension Adenosine (Adenocard)
Slows AV Conduction Supraventricular Tachycardia (Paroxysmal) Bradycardia Flushing Dyspnea Rapid IV Push Caffeine and Theophylline Decrease Effectiveness Dipyridamole May Intensify Effects Lidocaine
Blocks Na+ Channels Ventricular Arrhythmia Anesthetic Paresthesias Seizures Respiratory Depression Drowsiness Anesthetic Effects Extended with Epinephrine Angiotensin II Receptor Blockers (ARBs)
Ends in "-sartan" Blocks Angiotensin II Receptor Hypertension Angioedema Renal Artery Stenosis Pregnancy Sodium Nitroprusside (Nitropress)
Venous and Arterial Dilation Hypertensive Crisis Cyanide Toxicity Thiocyanate Toxicity Hypotension Short Term Administration Light Sensitive, Use Container Continuous BP Monitoring Beta-1 Agonists
Dobutamine Heart Failure Cardiac Stress Test Isoproterenol Bradyarrhythmias Torsades de Pointes View More
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