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Absolute Refractory Period In Preceding Na+ Channels
Neighboring Voltage Gate Channels Open
Nodes of Ranvier
Myelination Increases Propagation Speed
Saltatory Conduction
3 mins
Somatic Reflex Arc
Spinal Cord
Sensory (Afferent) Neuron
Interneurons Transmit
Motor (Efferent) Neuron
Effector Targets
1 min
Myasthenia Gravis
Mechanism
Antibodies to Acetylcholine Receptor
Symptoms
Ptosis
Diplopia
Weakness with Muscle Use
Respiratory Death
Thymus Associated
Treatment
Acetylcholinesterase Inhibitors
Plasmapheresis
Thymectomy
1 min
Lambert-Eaton Syndrome
Mechanism
Autoantibody to the Presynaptic Calcium Channel on Motor Neurons
Inhibits Acetylcholine (ACh) Release at Neuromuscular Junction
Paraneoplastic Syndrome
Small Cell Lung Cancer
Symptoms
Proximal Muscle Weakness
Improves with Muscle Use
Autonomic Symptoms
Extraocular Muscle Sparing
2 mins
Guillain-Barre Syndrome Assessment
Assessment
Ascending Paralysis
Muscle Weakness
Paresthesias (Pins and Needles)
Diplopia
Difficulty Speaking
Dysphagia
Labile Blood Pressure
Loss of Bowel and Bladder Control
Considerations
Aggressive Airway Management
2 mins
Vitamin B12 (Cobalamin) Mechanism and Deficiency
Mechanism
Cobalamin
Large reserve pool in the liver
Homocysteine to methionine
Methylmalonyl CoA to succinyl CoA
Deficiency Signs and Symptoms
Macrocytic Megaloblastic Anemia
Hypersegmented Neutrophils
Neurologic defects
Posterior column
Lateral corticospinal tract
Spinocerebellar tract
5 mins
Dandy-Walker Malformation
Characteristics
Cerebellar Vermis Hypoplasia
Cystic Enlargement of 4th Ventricle
Associations
Noncommunicating Hydrocephalus
Spina Bifida
1 min
Spina Bifida Assessment
Cause
Congenital Malformation of Vertebrae
Assessment
Dimple With or Without Hair Tuft
Lumbar Sac
Hydrocephalus
Paralysis
Considerations
Identify Type
2 mins
Glasgow Coma Scale
LOC Assessment
Score of 3 to 15
8 or Less = Coma
Eye Opening
Verbal Response
Motor Response
1 min
Serotonin Syndrome Assessment
Mild Signs & Symptoms
Restlessness
Diaphoresis
Tachycardia
Hypertension
Diarrhea
Moderate Signs & Symptoms
Hyperthermia
Decreased Level of Consciousness
Muscle Rigidity
Severe Signs & Symptoms
Seizure and Coma
Treatment
Cyproheptadine
2 mins
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