Laura Shared "INF Drug List" - 27 Picmonics

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INF Drug List

Macrolides
Bacteriostatic
Erythromycin
Azithromycin
Clarithromycin
Bind to 23S rRNA of 50S subunit
Inhibit protein synthesis by blocking translocation
Gram-Positive Cocci
Atypical pneumonia
Chlamydia
Resistance by methylation of 23S rRNA binding
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1 min
Macrolides Side Effects
Side Effects
Diarrhea
Prolonged QT Interval
P450 Inhibitor
Cholestatic Hepatitis
Skin Rash
Eosinophilia
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2 mins
1st Generation Cephalosporin
Drug Names
Cefazolin
Cephalexin
Indications (PEcK Mnemonic)
Proteus mirabilis
E. coli
Klebsiella
Gram-Positive Cocci
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3rd Generation Cephalosporin
Drug Names
Cefotaxime
Ceftriaxone
Cefdinir
Ceftazidime
Pseudomonas
Indications
Serious Gram-Negative Bacteria Resistant to Other Beta-Lactams
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Tetracycline Drug Names and Indications
Drug Names
Demeclocycline
Minocycline
Doxycycline
Fecally Eliminated
Can be Used in Renal Failure
Indications
Antidiuretic Hormone Antagonist
Chlamydia
Rickettsia
Borrelia burgdorferi
Helicobacter Pylori
Mycoplasma Pneumonia
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3 mins
Protein Synthesis Inhibitors
Drug Names
30S inhibitors
Aminoglycosides
Tetracyclines
50S inhibitors
Chloramphenicol
Clindamycin
Erythromycin
Lincomycin
Linezolid
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3 mins
Aminoglycosides
Drug Names
Gentamicin
Neomycin for Bowel Surgery Prep
Amikacin
Tobramycin
Streptomycin
Mechanism of Action
Bactericidal
Inhibit Formation of Initiation Complex
Cause Misreading of mRNA
Require O2 for Uptake
Resistance
Resistance by Transferase Enzymes
Acetylation
Phosphorylation
Adenylation
Indications
Gram-Negative Rod Infections
Synergistic with B-Lactam Antibiotics
Side Effects
Nephrotoxicity Especially When Used with Cephalosporins
Ototoxicity Especially When Used with Loop Diuretics
Teratogen
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5 mins
Imipenem
Mechanism
Resistant to beta lactamases
Broad Spectrum
Indications
Anaerobes
Gram-Negative Rods
Gram-Positive Cocci
Must administer with cilastatin
Cilastatin is inhibitor of renal dehydropeptidase I
Side Effects
Diarrhea
Skin rash
Seizures
Considerations
Meropenem
Stable to dehydropeptidase I
Reduced risk of seizures (Non seizure causing)
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2 mins
Fluoroquinolones Antibiotics
-floxacin
Mechanism of Action
Inhibits Topoisomerase II & IV
Bactericidal
Indications
Gram-negative Rods
Pneumonia
Gastrointestinal Infections
Urinary Tract Infection
Genital Infections
Drugs
Levofloxacin
Ciprofloxacin
Has Pseudomonas Coverage
Considerations
Avoid Polyvalent Cations
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Fluoroquinolones Toxicities
Diarrhea
Skin Rash
Headache
Tendon Rupture in Adults
Myalgias in Kids
Damage to Cartilage
Teratogen
QT Prolongation
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Metronidazole
Mechanism of Action
Bactericidal
Forms Free Radical Toxic Metabolites
Damages DNA
Indications
Giardia lamblia
Entamoeba Histolytica
Trichomonas
Gardnerella
Anaerobes
Side Effects
Metallic taste
Disulfiram like Reaction with Alcohol
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2 mins
Penicillin
Gram Positive
Spirochetes
Bind PBPs
Block Transpeptidase Cross-linking of Cell Wall
Activate Autolytic Enzymes
Bactericidal
Hypersensitivity Reactions
Hemolytic Anemia
Beta-lactamase Sensitive
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2 mins
Antipseudomonal Penicillins
Drugs
Ticarcillin
Carbenicillin
Piperacillin
Mechanism of Action
Same Mechanism as Penicillin
Indications
Extended Spectrum
Pseudomonas and Gram-Negative Rods
Considerations
Combine with Beta Lactamase Inhibitor
Clavulanic Acid
Tazobactam
Hypersensitivity Reactions
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2 mins
Aminopenicillin Mechanisms
Indications
Broader Spectrum
Drug Names
Ampicillin
Amoxicillin
Mechanism and Characteristics
Beta-Lactamase Sensitive
Combine with Clavulanic Acid
Side Effects
Hypersensitivity Reactions
Ampicillin Rash
Pseudomembranous Colitis
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2 mins
Beta-Lactamase Inhibitors
Considerations
Often Combined with Penicillin Antibiotics
Drug Names
Clavulanic Acid
Sulbactam
Tazobactam
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51 secs
Trimethoprim
Mechanism of Action
Bacteriostatic
Inhibits Bacterial Dihydrofolate Reductase
Causes Sequential Block of Folate Synthesis
Used in Combination with Sulfamethoxazole
Combination Used For Recurrent Urinary Tract Infections
Indications
Shigella
Salmonella
Pneumocystis Jiroveci Pneumonia
Side Effects
Decrease in Red and White Blood Cells
Alleviated with Leucovorin Rescue
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2 mins
Sulfonamides Mechanisms
Bacteriostatic
Gram-Positive
Gram-Negative
Nocardia
Chlamydia
PABA antimetabolites
Inhibit dihydropteroate synthase
Sulfamethoxazole
Sulfisoxazole
Sulfadiazine
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1 min
Vancomycin Mechanism
Bacteriostatic and Bactericidal
Gram-Positive
Inhibits Cell Wall Mucopeptide
Binds to D-ala D-ala
Resistance with change to D-ala D-lac
Staphylococcus aureus
Orally for Clostridium difficile
Enterococci
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2 mins
Vancomycin Side Effects & Toxicity
Side Effects
Thrombophlebitis
Nephrotoxicity
Ototoxicity
Diffuse Flushing Called Red Man Syndrome
Prevent with Antihistamine
Prevent with Slow Infusion
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2 mins
Isoniazid
Indications
Tuberculosis (TB)
Mechanism of Action
Requires Catalase Peroxidase
Decreases Mycolic Acid Synthesis
Fast vs Slow Acetylators
Side Effects
B6 Deficiency
Neurotoxicity
Hepatotoxicity
Drug-induced Lupus
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1 min

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