Glen Shared "Oncology Drugs" - 27 Picmonics

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Oncology Drugs

Azathioprine (Imuran)
Mechanism
Antimetabolite
Prodrug of 6-mercaptopurine (6-MP)
Inhibits Synthesis of Nucleic Acids
Indications
Autoimmune Disorders
Kidney Transplantation
Side Effects
Myelosuppression
Increased Toxicity with Allopurinol Use
Pancreatitis
Malignancy
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Cladribine
Purine analog
Inhibits DNA polymerase
DNA strand breaks
S Phase
Indication
Hairy Cell Leukemia
Adverse Effects
Myelosuppression
Nephrotoxicity
Neurotoxicity
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Cytarabine
Mechanism
Pyrimidine analog
Inhibits DNA Polymerase
Clinical use
Acute myelogenous leukemia (AML)
Lymphomas
Adverse effects
Myelosuppression
Megaloblastic anemia
Pancytopenia
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Fluorouracil (5-FU)
Mechanism
Antimetabolite
"Thymine-less Death"
Indications
Slow-growing Solid Tumors
Co-administered with Leucovorin for Stomach Cancer
Basal Cell Carcinoma (Topical)
Side Effects
Myelosuppression
Mucositis
Severe Diarrhea
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3 mins
Methotrexate
Indications
Rheumatoid Arthritis
Cancer
Medical Abortion
Mechanism
Folic Acid Analog
Inhibits Dihydrofolate Reductase
Side Effects
Pulmonary Fibrosis
Myelosuppression is Treated with Leucovorin Rescue (Folinic Acid)
Macrocytic Anemia
Hepatitis
Teratogenic
Mucositis
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1 min
Bleomycin
Indications
Testicular Cancer
Hodgkin's Lymphoma
Mechanism of Action
Induces Free Radical Formation
Breaks in DNA Strands
Side Effects
Pulmonary Fibrosis
Skin Changes
Mucositis
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1 min
Dactinomycin (Actinomycin D)
Indications
Wilms' Tumor
Rhabdomyosarcoma
Ewing's Sarcoma
Gestational Trophoblastic Malignancy
Mechanism
Intercalates DNA
Side Effect
Myelosuppression
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2 mins
Doxorubicin (Adriamycin)
Indications
Solid Tumors
Lymphomas and Leukemias
Mechanism
Free Radical Production
Intercalates DNA
Prevents Double Helix from Sealing
Side Effect
Cardiotoxicity
Dexrazoxane Decreases Toxicity
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1 min
Busulfan
Indications
CML
Bone Marrow Ablation
Mechanism
Cross-links DNA
Side Effects
Myelosuppression
Pulmonary Fibrosis
Hyperpigmentation
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1 min
Cyclophosphamide
Mechanism
Requires Bioactivation by Liver
Cross-links DNA
Guanine N7 Position
Indications
Autoimmune Disorders
Leukemia
Lymphoma
Solid Tumors
Side Effects
Myelosuppression
Hemorrhagic Cystitis
Prevent with Mesna
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3 mins
Nitrosoureas
Requires Bioactivation
Crosses Blood-Brain Barrier
Alkylating agent
Cross-Links DNA
Indication
Brain tumors
Including Glioblastoma Multiforme
Adverse effects
CNS Toxicity
Convulsions
Dizziness
Ataxia
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Paclitaxel
Stabilizes microtubules in M phase
Anaphase cannot occur
Indications
Ovarian Carcinoma
Breast carcinoma
Adverse effects
Myelosuppression
Neuropathy
Hypersensitivty
Alopecia
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Vincristine (Oncovin)
Mechanism
Vinca Alkaloid
Inhibits Microtubules
Indications
Leukemias
Lymphomas
Side Effects
Peripheral Neuropathy
Paralytic Ileus
Considerations
Vesicant
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Cisplatin
Indications
Carcinomas
Ovarian
Bladder
Lung
Testicular
Mechanism
Cross-Links DNA
Side Effects
Ototoxicity
Nephrotoxicity
Treat with Amifostine and Chloride Diuresis
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2 mins
Etoposide
Indications
Small Cell Lung Cancer
Testicular Cancer
Mechanism of Action
Inhibits Topoisomerase II
Errors in DNA Synthesis Cause Apoptosis
Side Effects
Myelosuppression
Alopecia
Hypotension
Nausea and Vomiting
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2 mins
Irinotecan and Topotecan
Inhibits Topoisomerase I
Prevents DNA unwinding and replication
Indications
Colon cancer (irinotecan)
Ovarian and Small Cell Lung Cancer (topotecan)
Adverse effects
Severe myelosuppression
Diarrhea
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Hydroxyurea
Mechanism
Inhibits Ribonucleotide Reductase
Decreased DNA Synthesis
S-phase Specific
Indications
Melanoma
Chronic Myelogenous Leukemia (CML)
Sickle Cell Disease
Through Increased HbF (Fetal Hemoglobin)
Side Effects
Myelosuppression
GI Distress
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2 mins
Prednisone (Glucocorticoids)
Mechanism
Glucocorticoid
Indications
Inflammatory Conditions
Organ Transplant Rejection
Side Effects
Cataracts and Glaucoma
Cushing's Syndrome
Osteoporosis
Immunosuppression
Hyperglycemia
Ulcers
Considerations
Adrenal Insufficiency
Taper Gradually
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2 mins
Bevacizumab Mechanisms and Indications
Mechanisms
Monoclonal Antibody to VEGF
Inhibits Angiogenesis (and Vasculogenesis)
Indications
Capillaries Grow CORN (CG-CORN acronym)
Colorectal Cancer
Glioblastoma
Cervical Cancer
Ovarian Cancer
Renal Cell Carcinoma
Non-small Cell Lung Cancer (NSCLC)
Age-related Macular Degeneration
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2 mins
Erlotinib and Cetuximab
Erlotinib
EGFR tyrosine kinase inhibitor
Treats Non-small Cell Lung Cancer
Causes a rash
Cetuximab
Monoclonal antibody against EGFR
Treats stage IV colorectal cancer
With KRAS mutation
Head and Neck Cancer
Causes Rash
Causes Diarrhea
Causes Elevated Liver Enzymes
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