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Adrenal Gland (Basic)
RAAS Stimulates Aldosterone
CRF (CRH) acts on Anterior Pituitary Gland to Release ACTH
No Internal Reproductive Structures Due to Mullerian Inhibitory Factor
XX Externally Phenotypic Female
21 Hydroxylase Deficiency
Increased 17 Hydroxyprogesterone
Signs and Symptoms
11 Beta-Hydroxylase Deficiency
Increased Sex Hormones
Increased 11 Deoxycorticosterone (11 DOC)
Signs and Symptoms
Blood Calcium Sensor
Blood Calcium Increases
Vitamin D Activation
Calcium Absorption From The Small Intestine
Long-Lived and Slow-Acting
Cushing's Syndrome Characteristics
More Common in Women
Primary Adrenal Disease
Pituitary Adenoma (Cushing's Disease)
Paraneoplastic: Small Cell Carcinoma
Cushing's Syndrome Symptoms And Diagnosis
Decreased Insulin Sensitivity
24-hour urine free Cortisol
Dexamethasone Suppression Test
Chronic 1° Adrenal Insufficiency
Deficiency In Cortisol And Aldosterone
ACTH (Cosyntropin) Stimulation Test
Acute 1° Adrenal Insufficiency
Adrenal Medulla Tumor
Abdominal or Chest Pain
Do Not Palpate Abdomen
Warm, Moist Skin and Silky Hair
Decreased TSH with Elevated Free T4
Radioactive Iodine Uptake (RAIU)
Weight Gain - Edema
Brittle Nails and Dry Skin
Decreased Free T4
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