Tyler Shared "SBM - week 5" - 64 Picmonics
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SBM - week 5
Giant Cell Tumor
- Pathophysiology
- Osteoclastoma
- Epiphyseal End of Long Bones
- Peak Incidence 20-40 Years
- Benign
- Knee Region
- Diagnosis
- Soap Bubble Appearance on X-ray
- Spindle-shaped Cells
- Multinucleated Giant Cells
46 secs
Ewing's Sarcoma
- Epidemiology
- Most Common in Boys < 15 years old
- Pathophysiology
- 11;22 Translocation
- Characteristics
- Long bones, Pelvis, Ribs
- Diaphysis
- Small Blue Cells
- Malignant
- Aggressive
- Onion-skin Appearance
- TREATMENT
- Responsive to Chemotherapy
2 mins
Chondrosarcoma
- Pathophysiology
- Cartilaginous tumor
- Malignant
- Men 30-60 years old
- Pelvic and femur bones
- Signs & Symptoms
- Glistening mass in medullary cavity
- Can be primary in origin or from osteochondroma
- Metastasize to lungs
1 min
Osteosarcoma
- Pathophysiology
- Osteogenic Sarcoma
- Peak incidence men 10-20 years old
- Metaphysis of Long Bones
- Knee Region
- Radiation
- Familial Retinoblastoma
- Paget's Disease
- Diagnosis
- Codman Triangle
- Sunburst Pattern from Elevated Periosteum
- Grave Prognosis
2 mins
Melanoma Diagnosis
- Signs
- ABCDE Mnemonic
- Asymmetry
- Border irregularity
- Color variation
- Diameter > 6mm
- Evolution over time
- Diagnosis
- S-100 Tumor Marker
- LDH (Lactate Dehydrogenase) Screens for Metastasis
- Treatment
- Wide Local Excision
- Adjuvant Therapy
1 min
Melanoma Mechanism and Characteristics
- Mechanism
- Associated with Sunlight Exposure
- Mutation in B-RAF kinase
- Large Number of Moles
- Fair-Skinned People at Higher Risk
- Growth Phases
- Radial Growth Phase
- No Metastasis
- Vertical Growth Phase
- Depth of Tumor Correlates with Risk of Metastasis
1 min
Parvovirus B19
- Characteristics
- DNA
- Single Stranded
- Linear
- Smallest DNA virus
- Non-enveloped
- Signs and Symptoms
- 5th Disease
- Slapped Cheek Rash in Children
- Erythema Infectiosum
- Hydrops Fetalis
- RBC aplasia
- Arthritis in Adults
- Aplastic Crisis in Sickle Cell
- Myocarditis
2 mins
Roseola
- Exanthem
- Herpesvirus 6
- Enveloped
- Double Stranded DNA
- Linear
- Signs and Symptoms
- High Fevers Can Lead to Seizures
- Diffuse Macular Rash After Fever
1 min
Lichen Planus
- Pathophysiology
- Mucocutaneous Disorder
- 30-60 year olds
- Signs & Symptoms
- Pruritic
- Plaques or Papules
- Purple & Polygonal
- Often Mucosal or Genital Involvement
- Wickham Striae
- Diagnosis
- Biopsy
- Sawtooth Infiltrate of Lymphocytes
- Treatment
- Topical Corticosteroids
- Considerations
- Hepatitis C Association
2 mins
Anti-desmoglein Antibodies
- Pemphigus Vulgaris
- Flaccid Blisters
- Skin and Oral Mucosa
- Positive Nikolsky's Sign
59 secs
Bullous Pemphigoid
- Linear Deposits of IgG
- Affects Hemidesmosomes
- Epidermal Basement Membrane
- Tense Blisters on Skin
- Nikolsky Negative
- Contain Eosinophils
- Rarely Affect Oral Mucosa
2 mins
Varicella Zoster Virus (VZV)
- Herpesvirus 3
- Characteristics
- Enveloped
- Double Stranded DNA
- Signs and Symptoms
- Chickenpox
- Pneumonia
- Encephalitis
- Trigeminal and Dorsal Root Ganglia
- Shingles
- Diagnosis
- Tzanck Test
- Multinucleated Giant Cells
- Cowdry A Inclusion
- Treatment
- Acyclovir
2 mins
Pityriasis Versicolor (Tinea versicolor)
- Mechanism
- Lipid-Dependent Fungus
- Fatty Acids Damage Melanocytes
- Malassezia Furfur
- Hot, Humid Weather
- Signs and Symptoms
- Hypopigmentation
- Hyperpigmented Patches
- Diagnosis
- Spaghetti and Meatball Appearance on KOH Prep
- Fragmented Hyphae with Clusters of Yeast
- Treatment
- Topical or Oral Antifungals
- Selenium Sulfide
- Zinc
4 mins
Pseudomonas Aeruginosa Disease
- Signs and Symptoms
- Pneumonia
- Cystic Fibrosis
- Burn Wounds
- Hot tub folliculitis
- Urinary Tract Infections
- Osteomyelitis associated with IV drug use
- Osteomyelitis from Shoe Puncture Wound
- Diabetic Osteomyelitis
- Corneal Infections in contact lens users
- Endocarditis
- Ecthyma Gangrenosum
3 mins
Leishmania donovani
- Pathophysiology
- Protozoan
- Visceral Leishmaniasis
- Hepatosplenomegaly
- Spiking Fevers
- Skin Pigmentation
- Sandfly
- Diagnosis
- Macrophages with Amastigotes
- Treatment
- Amphotericin B
- Oral Miltefosine
2 mins
Sporothrix Schenckii
- Characteristics
- Fungi
- Thermally Dimorphic
- Cigar-shaped Yeast Forms
- Rose Thorn Prick
- Packaging Peat Moss
- Signs & Symptoms
- Local Pustule or Ulcer
- Nodules on Draining Lymphatics
- Treatment
- Potassium Iodide
- Itraconazole
2 mins
Chronic Mucocutaneous Candidiasis
- Mechanism and Characteristics
- T Cell Dysfunction
- Candida Albicans
- Signs and Symptoms
- Infections of Skin
- Infections of Mucous Membrane
- Susceptible to HPV Infections like Condyloma Acuminatum
42 secs
Candida Albicans
- Fungi
- Yeast with Pseudohyphae at 20 Degrees C
- Germ Tube Formation at 37 Degrees C
- Pruritic Vaginitis
- White Cottage Cheese Discharge
- Fiery Red Mucosa
- Diabetics
- Antibiotic Use
- Esophageal Thrush in Immunocompromised
- Diaper Rash
- Endocarditis in IV Drug Users
2 mins
Terbinafine
- Indications
- Dermatophytosis
- Onychomycosis
- Mechanism
- Inhibits Squalene Epoxidase
- Side Effects
- Hepatotoxicity
- GI Distress
- Taste Disturbances
- Headache
2 mins
Amphotericin B
- Indications
- Systemic Mycosis
- Fungal Meningitis
- Last Resort for Protozoan infections
- Mechanism
- Polyene
- Binds Ergosterol
- Forms Membrane Pores
1 min
