Ryan Shared "B4 Path 1" - 15 Picmonics

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B4 Path 1

Microscopic Polyangiitis
Pathophysiology
Necrotizing Small Vessel Vasculitis
Signs and Symptoms
Lungs, Kidneys, and Skin Commonly Affected
Palpable purpura
Rapidly Progressive Cresentic Glomerulonephritis
Diagnosis
Lesions are Same Age
Non-granulomatous
Minimal Nasopharyngeal Involvement
P-ANCA
Treatment
Corticosteroids
Cyclophosphamide
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2 mins
Granulomatosis With Polyangiitis (Wegeners) Characteristics
Pathophysiology
Granulomatosis With Polyangiitis
Vasculitis
Necrotizing
C ANCA
Lungs And Upper Airway
Crescentic Glomerulonephritis
Treatment
Cyclophosphamide
Corticosteroids
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1 min
Granulomatosis with Polyangiitis (Wegeners) Symptoms
Signs and Symptoms
Lung Involvement
Cough
Hemoptysis
Chronic Sinusitis
Saddle Nose
Perforation of Nasal Septum
Otitis Media
Glomerulonephritis
Hematuria
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3 mins
Eosinophilic Granulomatosis with Polyangiitis (Churg-Strauss Syndrome)
Pathophysiology
Granulomatous Vasculitis
Signs and Symptoms
Sinusitis
Skin Lesions
Peripheral Neuropathy
Asthma
GI Disease
Heart Disease
Kidney Failure
Diagnosis
Eosinophilia
p-ANCA
Treatment
Corticosteroids
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3 mins
Henoch-Schonlein Purpura
Most Common Childhood Vasculitis
Follows Pharyngeal or Respiratory Infection
Palpable Purpura on Legs and Buttocks
Arthralgia
Intestinal Hemorrhage
Black Stool (Melena)
Associated with IgA Nephropathy
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2 mins
Kawasaki Disease
Pathophysiology
Prevalent in Asian Children
Necrotizing Vasculitis
Signs and Symptoms
Fever
Strawberry-Red Tongue and Mucosa
Lymphadenopathy
Desquamative Skin Rash
Erythema and Edema of the Hands and Feet
Conjunctivitis
Coronary Aneurysm
Treatment
Intravenous Immunoglobulin (IVIG)
Aspirin
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2 mins
Kawasaki Disease
Prevalent In Asian Children
Necrotizing Vasculitis
fever
Erythema And Edema Of The Hands And Feet
Conjunctivitis
Aspirin
t cell mediated
Coronary Aneurysm
Myocardial Infarction
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Kawasaki (mnemonic: CRASH BURN)
Acute (0-2wks)
Labs: normochromic anemia, leukocytosis with left shift
Elevated ESR&CRP
subacute (2-8wks)
Gradual decline in ESR&CRP
Labs: thrombocytosis
Untreated children develop coronary artery aneurysms
ECHO (at diagnosis for baseline, at 2 weeks, at 8 weeks)
chronic (>8wks)
Begins when all clinical symptoms have disappeared
Treatment
high dose aspirin
IVIG (Intravenous Immunoglobulin)
Low dose aspirin for 6wks
Chronic Anticoagulation (if aneurysm present) with aspirin or other antiplatelet medications
Corticosteroids ONLY if refractory to IVIG
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Buerger's Disease
Pathophysiology
Thromboangiitis Obliterans
Segmental Inflammation
Strong Association with Smoking
Signs and Symptoms
Superficial Nodular Phlebitis
Raynaud's Phenomenon
Autoamputation
Treatment
Smoking Cessation
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2 mins
Buerger Disease
Thromboangiitis obliterans
Segmental inflammation
Smoking
Raynauds phenomenon
Autoamputation
luminal thrombosis
histology
Superficial nodular phlebitis
location
Necrotizing Vasculitis
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polyarteritis nodosa
Cyclophosphamide
pearls
young adults
Fatal If Not Treated
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Polymyalgia Rheumatica
Symptoms
Shoulder and hip pain and stiffness
Fever
General Malaise
Weight loss
No muscular weakness
Women over 50
Temporal (giant cell) Arteritis
Low-dose corticosteroids
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Temporal Arteritis
Giant Cell Arteritis
Granulomatous
Old females
Polymyalgia rheumatica
Unilateral headache
Jaw claudication
Blindness
Increased ESR
Normal serum creatine kinase
Steroids
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2 mins
Takayasu's Arteritis
Pathophysiology
Granulomatous Thickening of Aortic Arch
Pulseless Disease
Asian Females
Signs and Symptoms
Fever
Myalgia
Night Sweats
Arthritis
Ocular Disturbances
Diagnosis
Increased ESR
Different Blood Pressures in Arms
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2 mins
Takayasu Arteritis
Pulseless Disease
Women under 40
Ocular Disturbances
Granulomatous vasculitis
Granulomatous Thickening Of Aortic Arch
luminal narrowing
Asian Females
all layers
brain ischemia
Pulmonary Hypertension
Myocardial Infarction
Renal Insufficiency
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