Gregory Shared "immuno" - 66 Picmonics
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immuno
Immune System Tissues
- Characteristics
- Bone Marrow
- B Cells and T Cells Formed
- B Cells Mature
- Thymus
- T Cells Tested For Self-Response
- T Cells Mature
- Lymph Nodes
- Mature B Cells and T Cells Monitor Lymph For Pathogens
- Spleen
- Mature B Cells and T Cells Monitor Blood For Pathogens
1 min
Lymphatics
- Characteristics
- Recycles 10% of Interstitial Fluid
- Transport Large Lipids from Lacteals
- Unidirectional Valves
- Lymph Nodes Filter Lymph
- WBCs Monitor Lymph for Pathogens
- Merge with Veins
2 mins
Lymphatics: Treatments
- Diaphragm Release
- Thoracic Inlet Release
- Doming the Diaphragm
- Pelvic Diaphragm Release
- HEENT: Head, Eyes, Ears, Nose and Throat
- Auricular Drainage Technique
- Effleurage
- Anterior Cervical Mobilization
- Galbreath Technique
- Mechanically Mobilizing the Lymphatics
- Cranial Field Osteopathy
- Muscle Energy: Thoracic Inlet
- Thoracic Pump
- Splenic Pump
- Liver Pump
- Pedal Pump
- Rib Raising
5 mins
Lymphatics: Osteopathic Overview
- Left Lymphatic (Thoracic) Duct
- Left Head and Neck
- Left Thorax and Upper Extremity
- Abdomen and Lower Extremities
- Right Lymphatic Duct
- Right Head and Neck
- Right Thorax and Upper Extremity
- Diaphragms
- Thoracic Inlet
- Thoracic Diaphragm
- Pelvic Diaphragm
- Considerations
- Tissue Changes
- Chapman's Points
- Tense Pelvic Diaphragm
- Restricted Thoracic Cage Movement
4 mins
Lymph Node Drainage
- Submandibular and Submental
- Cervical
- Supraclavicular
- Hilar and Mediastinal
- Axillary
- Epitrochlear
- Celiac, Superior Mesenteric, and Inferior Mesenteric
- Para-aortic
- Periumbilical (Sister Mary Joseph Node)
- Internal Iliac
- Superficial Inguinal
- Popliteal
- External Illiac
3 mins
Innate Immunity Barriers
- Skin Protects Against Pathogens
- Normal Flora Outcompete Pathogens
- Lysozyme in Saliva, Tears, and Mucus
- Mucous Traps Pathogens
- Cilia Remove Mucus
- Acid and Digestive Enzymes in the Stomach Kill Pathogens
2 mins
Innate Immunity Cellular Response
- Characteristics
- Natural Killer Lymphocytes Attack Abnormal Cells
- Neutrophils in Blood
- Infected Cells Release Interferon
- Complement Proteins Lyse Pathogens/Infected Cells
- Dendritic Cells in Tissue
- Macrophages in Tissue
2 mins
Humoral Adaptive Immunity
- Characteristics
- B Cell Binds Free Floating Antigen
- B Cell Presents Antigen to Helper T Cell
- Helper T Cells Help B Cells Develop Antigen Specificity
- Plasma B Cells Secrete Antibodies
- Memory B Cells Cause Faster Secondary Response
2 mins
Cell-mediated Adaptive Immune Response
- Characteristics
- Macrophages and Dendritic Cells Present Antigens
- T Cell Develops Antigen Specificity
- Regulatory T Cells Suppress Response
- Memory T Cells Cause Faster Secondary Response
- Cytotoxic T Cells Lyse Infected Cells
- Infected Cells Present Antigen On Surface
2 mins
HLA-B27 Associations
- Associations
- PAIR Acronym
- Psoriatic Arthritis
- Ankylosing Spondylitis
- Inflammatory Bowel Disease
- Reactive Arthritis
1 min
HLA-DR3 Associations
- Characteristics
- MHC II
- Autoimmune Diseases
- Associations
- Type 1 Diabetes
- Systemic Lupus Erythematosus (SLE)
- Hashimoto's Thyroiditis
- Graves Disease
- Addison’s Disease (Primary Adrenal Insufficiency)
2 mins
HLA-DR4 Associations
- Characteristics
- MHC II
- Autoimmune Diseases
- Associations
- Rheumatoid Arthritis
- Type 1 Diabetes
- Pemphigus Vulgaris
- Addison's Disease (Primary Adrenal Insufficiency)
2 mins
IPEX Syndrome
- Characteristic
- X-Linked
- Onset First Year of Life
- Immune Dysregulation
- Regulatory T Cells Dysfunction
- Deficiency of FOXP3
- Autoimmune
- Polyendocrinopathy
- Endocrinopathy
- Type I Diabetes Mellitus
- Enteropathy
- Enteropathy
- Severe Diarrhea
- Other Features
- Dermatitis
- Nail Dystrophy
- Treatment
- Bone Marrow Transplantation
2 mins
Antibody Structure
- V (Variable) Region
- C (Constant) Region
- Fab
- Antigen-Binding Site
- Heavy Chain
- Light Chain
- Disulfide Bonds
- Fc
- Complement Binding
- Macrophage Binding
2 mins
Immunoglobulin Isotypes
- IgM
- Primary Immune Response
- Cold Agglutinin Autoimmune Hemolytic Anemia (C-AIHA)
- IgG
- Crosses Placenta
- Warm Agglutinin Autoimmune Hemolytic Anemia (W-AIHA)
- IgA
- Released in Secretions, Mucosal Fluids, and Breast Milk
- IgD
- IgE
- Against Parasitic Worms
- Allergic Reaction
3 mins
Complement Disorders
- Early Complement Deficiency
- Pyogenic Infections
- SLE
- Sinus Infections
- Terminal Complement Deficiency
- Autosomal Recessive
- Neisseria Infections
- C5-C9
- MAC (Membrane Attack Complex)
4 mins
C1 Esterase Inhibitor Deficiency
- Pathophysiology
- Autosomal Dominant
- Disinhibition of Kallikrein
- Increased Bradykinin
- Decreased C4
- Clinical Features
- Recurrent Angioedema
- Upper Airway Obstruction
- Considerations
- ACE Inhibitors Contraindicated
- Avoid Triggers
3 mins
Paroxysmal Nocturnal Hemoglobinuria (PNH)
- Pathophysiology
- Defective PIG-A Gene
- Deficiency of DAF (Decay Accelerating Factor CD55)
- Symptoms
- Dark Urine in the Morning
- Intravascular Hemolysis
- Thrombosis
- Diagnosis
- Decreased CD55 and CD59
- Treatment
- RBC Transfusion
- Eculizumab
- Bone Marrow Transplant is Curative
3 mins
Chronic Granulomatous Disease
- Pathophysiology
- Most Commonly X-linked Recessive
- Defective NADPH Oxidase (Enzyme Complex)
- Decreased Hydrogen Peroxide
- Impaired Intracellular Killing in Phagocytes
- Signs and Symptoms
- Recurrent Purulent Skin and Lung Infections
- Catalase Positive Organisms
- Diagnosis
- Negative Nitroblue Tetrazolium Test
- DHR (Dihydrorhodamine) Flow Cytometry
- Treatment
- Antimicrobial Prophylaxis
- TMP-SMX
- Itraconazole
- Interferon-Gamma
3 mins
Cell Surface Proteins - B Cells
- Ig
- CD19
- CD20
- CD21
- CD40
- MHC II
- B7
1 min
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