Dylan Shared "Copy of Path Test Two" - 110 Picmonics
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Autosomal Dominant Condition Leading to Reduced vWF
Defect in platelet plug formation
Increased Bleeding Time
Factor VIII decreased
Normal platelet count
DDAVP (synthetic vasopressin)
Protein C or S Deficiency
Inability to Inactivate Factor Va and VIIIa
Recurrent DVTs or DVTs at Young Age
Slowly Bridge to Warfarin
Hemorrhagic Skin Necrosis
Polycythemia Vera Disease
JAK2 Mutation leading to increased red blood cells
Often After Hot Shower
Polycythemia Vera Labs
Lab Findings (The 4 H's)
Elevated Hemoglobin or Hematocrit
Positive Jak2 Mutation
Factor V Leiden Thrombophilia
Most Common Genetic Clotting Disorder in Caucasians
Genetic Point Mutation
Glutamine Replaces Arginine
Mutant Factor V
Resistant to Degradation by Activated Protein C
Recurrent DVT (Increased Risk of Thromboembolism)
Avoid Oral Contraceptives
Caution During Pregnancy
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