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Cade Shared "Lecture 104: TB and Leprosy" - 6 Picmonics

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Lecture 104: TB and Leprosy

Tuberculosis Intervention
Hospital Care
Airborne Isolation
Drug Therapy
Combination Drug Therapy (RIPE)
6-12 Months
Considerations
DOT
BCG Vaccination
Medication Education
3 Negative Sputum Specimens
Infection Control
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2 mins
Pyrazinamide
INDICATIONS
Mycobacterium tuberculosis
MECHANISM
Pyrazinoic Acid
Most Efficient at Acidic pH
Unknown Mechanism
SIDE EFFECTS
Gout (Hyperuricemia)
Liver Toxicity
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3 mins
Ethambutol
Mechanism of Action
Bacteriostatic
Blocks Arabinosyltransferase
Arabinosyltransferase Polymerizes Carbohydrates
Carbohydrate Polymers Make Mycobacterium TB Cell Wall
Side Effects
Red/Green Color Blindness
Reversible with Drug Discontinuation
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40 secs
Rifampin
Tuberculosis (TB)
Blocks RNA Polymerization
Haemophilus influenzae Type B
Leprosy
Meningitis
P450 inducer
Red-orange urine
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55 secs
Dapsone
Mechanism
Inhibits Dihydropteroate Synthase
Structural Analog of PABA
Similar to Sulfonamides
Impairs Folic Acid Synthesis
Indications
Leprosy
Pneumocystis jirovecii
Dermatitis Herpetiformis
Adverse Effects
Hemolysis in G6PD Deficient Patients
Methemoglobinemia
Agranulocytosis
Peripheral Neuropathy
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3 mins
Isoniazid
Indications
Tuberculosis (TB)
Mechanism of Action
Requires Catalase Peroxidase
Decreases Mycolic Acid Synthesis
Fast vs Slow Acetylators
Side Effects
B6 Deficiency
Neurotoxicity
Hepatotoxicity
Drug-induced Lupus
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1 min

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Cade Shared Lecture 104: TB and Leprosy - 6 Picmonics