Cade Shared "Lecture 104: TB and Leprosy" - 6 Picmonics
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Lecture 104: TB and Leprosy
- Hospital Care
- Airborne Isolation
- Drug Therapy
- Combination Drug Therapy (RIPE)
- 6-12 Months
- Considerations
- DOT
- BCG Vaccination
- Medication Education
- 3 Negative Sputum Specimens
- Infection Control
- INDICATIONS
- Mycobacterium tuberculosis
- MECHANISM
- Pyrazinoic Acid
- Most Efficient at Acidic pH
- Unknown Mechanism
- SIDE EFFECTS
- Gout (Hyperuricemia)
- Liver Toxicity
- Mechanism of Action
- Bacteriostatic
- Blocks Arabinosyltransferase
- Arabinosyltransferase Polymerizes Carbohydrates
- Carbohydrate Polymers Make Mycobacterium TB Cell Wall
- Side Effects
- Red/Green Color Blindness
- Reversible with Drug Discontinuation
- Tuberculosis (TB)
- Blocks RNA Polymerization
- Haemophilus influenzae Type B
- Leprosy
- Meningitis
- P450 inducer
- Red-orange urine
- Mechanism
- Inhibits Dihydropteroate Synthase
- Structural Analog of PABA
- Similar to Sulfonamides
- Impairs Folic Acid Synthesis
- Indications
- Leprosy
- Pneumocystis jirovecii
- Dermatitis Herpetiformis
- Adverse Effects
- Hemolysis in G6PD Deficient Patients
- Methemoglobinemia
- Agranulocytosis
- Peripheral Neuropathy
- Indications
- Tuberculosis (TB)
- Mechanism of Action
- Requires Catalase Peroxidase
- Decreases Mycolic Acid Synthesis
- Fast vs Slow Acetylators
- Side Effects
- B6 Deficiency
- Neurotoxicity
- Hepatotoxicity
- Drug-induced Lupus
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