Wayne Shared "Chapter 3 Pathology Bliss" - 8 Picmonics
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Chapter 3 Pathology Bliss
- Redness (Rubor)
- Warmth (Calor)
- Swelling (Tumor)
- Pain (Dolor)
- Loss of Function (Functio laesa)
- Definition
- Inflammation Markers
- Positive (Upregulated)
- Ferritin
- Fibrinogen
- Serum Amyloid A
- Hepcidin
- Haptoglobin
- Procalcitonin
- C-Reactive Protein
- Alpha-1 Antitrypsin
- Negative (Downregulated)
- Albumin
- Transferrin
- Transthyretin
- Systemic Manifestation
- Fever
- Leukocytosis
- Pathogens Infect Tissue
- Mast Cells Release Histamine
- Histamine Dilates and Increases Capillary Permeability
- Macrophages Engulf Pathogens
- Macrophage Signals Cells With Cytokines
- Responding Neutrophils Cross Capillary Wall
- B And T Lymphocytes Arrive At Injury Site
- Interleukin-1 (IL-1)
- Interleukin-6 (IL-6)
- Tumor Necrosis Factor-Alpha (TNF-α)
- Interleukin-8 (IL-8)
- Interleukin-12 (IL-12)
- IL-1 (Macrophage)
- Neutrophil & Macrophage Migration
- Fever & Shock
- IL-2 (T-Cells)
- T-Cells Proliferation
- NK & Macrophage Activity
- B-Cell Growth
- IL-3 (T-Cells)
- Hematopoisis
- IL-4 (Th2)
- Th2 Cell Differentiation
- B-Cell Growth
- Isotype Switch to IgE
- IL-5 (Th2)
- Eosinophil Differentiation
- Isotype Switch to IgA
- IL-6 (Macrophage)
- T & B Cell Growth
- Osteoclast Activity
- Fever
- IL-8 (Macrophages T-Cells)
- Neutrophil Chemotaxis
- IL-10 (Th2)
- Blocks TH1 Differentiation
- Decreases cell-mediated immunity & APC activity
- Increase B-Cell Function
- IL-12 (Macrophage)
- Th1 Differentiation
- Increase NK and CD8 Activity
- Mechanism
- Downregulates Pro-inflammatory Cytokines
- Decreased Lymphocyte Activation and Migration
- Granuloma Breakdown
- Treats
- Crohn's Disease
- Rheumatoid Arthritis
- Juvenile Rheumatoid Arthritis
- Psoriasis
- Ankylosing Spondylitis
- Etanercept
- Decoy TNF- Alpha receptor
- Anti-TNF- Alpha antibody
- Adalimumab
- Infliximab
- Complications
- Increased risk of infection
- Predispose to Tuberculosis (TB) reactivation
- Order Baseline PPD- skin test
- Quantiferon Gold In-Tube
- Order Chest X-Ray
- IL-1, IL-6 and TNF-alpha
- IL-1 Activates Endothelium
- TNF-alpha Maintains Granulomas
- TNF-alpha Increases Vessel Permeability
- TNF-alpha Activates Endothelium and Recruits WBCs
- IL-6 Increases Acute Phase Reactants
- IL-8 recruits Neutrophils
- IL-12 induces T cells into Th1 cells
- IL-12 activates Natural Killer cells
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