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STEP 2 - renal
Rapidly Progressive Glomerulonephritis
Crescents Consist of Fibrin and C3b
Post Streptococcal Glomerulonephritis
Signs and Symptoms
Cola Colored Urine
Follows Group A Streptococcal pharyngitis or Skin Infection
Immunofluorescence (IF) Granular
Lumpy Bumpy Appearance on Immunofluorescence (IF)
Subepithelial Immune Complex Humps
Berger's Disease (IgA Nephropathy)
Immune Complex Deposit in Mesangium
Increased Synthesis of IgA
Most Common Cause of Nephritic Syndrome
Overlapping Features with Henoch–Schönlein Purpura
Presents with Pharyngitis, URI or Acute Gastroenteritis
LM Thickening of Capillary and Glomerular Basement Membrane (GBM)
EM Spike and Dome Appearance with Subepithelial Deposits
Phospholipase A2 Receptor Autoantibodies
Hepatitis B Virus (HBV)
Subendothelial Immune Complexes
Hepatitis C Virus
Tram Tracks Caused by Splitting of the GBM
Ingrowth of Mesangium
Dense Deposit Disease
C3 Nephritic Factor
Nonenzymatic Glycosylation of Glomerular Basement Membrane
Nonenzymatic Glycosylation of Arterioles
Type IV Collagen Deposition
Kimmelstiel Wilson Lesions
Congo red stain
Apple green birefringence
Focal Segmental Glomerulosclerosis
Most Common Cause of Nephrotic Syndrome in Hispanics and African Americans
Associated with Sickle Cell Disease and HIV
Associated Interferon Therapy and Heroin Abuse
LM Segmental Sclerosis and Hyalinosis
EM Focal Damage of Visceral Epithelial Cells
Signs & Symptoms
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