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Acute Myelogenous Leukemia (AML)
Myeloblasts Increase on Peripheral Smear
Median Onset 60 Years
T 15;17 M3 Subtype
Disseminated Intravascular Coagulation (DIC) is a Common Presentation
M5 Gum Infiltration
Responds to Vitamin A
Chronic Myelogenous Leukemia (CML)
Age 30 to 90 Years
Low Alkaline Phosphatase (ALK-P)
Blast Crisis can Accelerate and Transform to AML or ALL
Acute Lymphoblastic Leukemia (ALL)
Ages < 15
May Present with Bone Marrow Involvement in Children
Mediastinal Mass in Adolescents
t(12;21) Better Prognosis
Spread to CNS and Testes
Most Responsive to Chemotherapy
Chronic Lymphocytic Leukemia (CLL)
Signs and Symptoms
Age > 60 Years
B Cell Neoplasm
Cold IgM Autoimmune Hemolytic Anemia
Warm IgG Autoimmune Hemolytic Anemia
Hairy Cell Leukemia
Mature B Cell Tumor
Signs and Symptoms
Cells Have Filamentous Hair-Like Projections
Stains TRAP Positive
Dry Tap on Bone Marrow Aspiration
May Have Normal or High WBC Count
Bone Marrow Aspiration
Bone Marrow Transplant
Monitor Temperature Elevations
Imatinib (Gleevec) for Chronic Myelogenous Leukemia (CML)
Adolescents or young adults
C-myc gene moves next to heavy chain Ig gene
Starry sky appearance
Sheets of lymphocytes with interspersed macrophages
Jaw lesion in endemic (African) form
Pelvis or abdomen in non endemic form (American form)
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