Eddie Shared "pathology" - 64 Picmonics
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pathology
Burkitt's Lymphoma
- Adolescents or young adults
- C-myc gene moves next to heavy chain Ig gene
- T 8;14
- Starry sky appearance
- Sheets of lymphocytes with interspersed macrophages
- Jaw lesion in endemic (African) form
- Pelvis or abdomen in non endemic form (American form)
- Associated with EBV
2 mins
Diffuse Large B Cell Lymphoma
- Epidemiology
- Most Common Non-Hodgkin’s Lymphoma
- Usually in Older Adults
- 20% in Children
- Features
- May be Mature T Cell in Origin
- Derives from Germinal Center
- GI Tract and Brain
2 mins
Follicular Lymphoma
- Derives from Germinal Center
- Occurs in adults
- T14;18
- BCL 2 overexpression
- BCL 2 inhibits apoptosis
- Indolent
- Generalized lymphadenopathy
- Bone marrow involvement
2 mins
Mantle Cell Lymphoma
- Older Males
- Activation of Cyclin D Gene
- T 11;14
- CD5
- Poor Prognosis
55 secs
Multiple Myeloma Pathophysiology
- Pathophysiology
- Monoclonal Plasma Cell Cancer
- Clock Face Chromatin
- Diagnosis
- M Spike on Protein Electrophoresis
- Increased IgG and IgA
- Fried Egg Appearance (BM Biopsy)
- Rouleaux Formation
- Stacked RBC's
- Bence Jones Protein
2 mins
Multiple Myeloma Signs and Symptoms
- Signs and Symptoms
- Increased Susceptibility to Infection
- Back/Bone Pain
- Punched Out Lytic Bone Lesions
- Hypercalcemia
- Primary Amyloidosis
- Renal Insufficiency
- Anemia
2 mins
Chronic Myelogenous Leukemia (CML)
- Pathophysiology
- BCR-ABL
- 9;22 Translocation
- Philadelphia Chromosome
- Signs & Symptoms
- Tyrosine Kinase
- Low Alkaline Phosphatase
- Splenomegaly
- Considerations
- Blast Crisis
- Age 30 to 90 Years
- Responds to Imatinib
3 mins
Acute Myelogenous Leukemia (AML)
- Myeloblasts Increase on Peripheral Smear
- Median Onset 60 Years
- T 15;17 M3 Subtype
- Auer Rods
- Disseminated Intravascular Coagulation (DIC) is a Common Presentation
- M5 Gum Infiltration
- Responds to Vitamin A
3 mins
Chronic Lymphocytic Leukemia (CLL)
- Signs and Symptoms
- Age > 60 Years
- B Cell Neoplasm
- Smudge Cells
- Often Asymptomatic
- Cold IgM Autoimmune Hemolytic Anemia
- Warm IgG Autoimmune Hemolytic Anemia
- Richter's Transformation
3 mins
Polycythemia Vera Disease
- Pathophysiology
- JAK2 Mutation leading to increased red blood cells
- Tyrosine Kinase
- Symptoms
- Erythromelalgia
- Pruritus
- Often After Hot Shower
- Headache
- Treatment
- Phlebotomy
- Aspirin
1 min
Polycythemia Vera Labs
- Lab Findings (The 4 H's)
- Hypervolemia
- Histaminemia
- Hyperviscosity
- Hyperuricemia
- Diagnosis
- Elevated Hemoglobin or Hematocrit
- Positive Jak2 Mutation
1 min
Endometriosis Characteristics
- Endometrial Tissue Outside of Uterus
- Glands and Stroma
- Most Common in Ovary, Pelvis, Peritoneum and Bowels
- "Chocolate Cyst" in Ovary
- Adenomyosis
- Theories
- Retrograde Flow
- Metaplastic Transformation
- Mullerianosis
2 mins
Endometriosis Symptoms and Treatment
- Symptoms
- Dysmenorrhea
- Cyclic Pelvic Pain
- Dyschezia
- Dysuria
- Dyspareunia
- 30-40% are Infertile
- Treatment
- Surgery
- NSAIDs
- OCPs
- Progesterone (Progestins)
- GnRH Agonists
1 min
Polycystic Ovarian Syndrome (PCOS) Treatment
- Weight Loss
- Oral Contraceptives
- Clomiphene Citrate
- Anti-androgens
- Cyclic Progesterone for Endometrial Protection
- Metformin
1 min
Krukenberg Tumor
- Non-germ Cell Tumor
- Lymphatic Spread to Ovaries
- Metastasis
- GI Malignancy
- Mucin-secreting Signet Cell
34 secs
Choriocarcinoma
- Germ-cell tumor
- Trophoblastic tissue
- Hematogenous spread to lungs
- Malignant
- Theca-lutein cysts
- Hydatidiform Mole
- hCG
59 secs
Pelvic Inflammatory Disease (PID)
- Mechanism
- Neisseria gonorrhoeae
- Chlamydia Trachomatis
- Symptoms
- Cervical Motion Tenderness
- Chandelier Sign
- Salpingitis
- Tubo-ovarian abscess
- Hydrosalpinx
- Complications
- Ectopic Pregnancy
- Infertility
- Adhesions
- Fitz-Hugh-Curtis Syndrome
2 mins
Tamoxifen
- Mechanism of Action
- Selective Estrogen Receptor Modulator (SERM)
- Antagonist on Breast Tissue
- Indications
- ER-positive Breast Cancer
- Side Effects
- Decreased Risk of Osteoporosis
- Increased Risk of Endometrial Cancer
- Increased Risk of Venous Thromboembolism (VTE)
1 min
Ovarian Cystadenoma
- Non-germ cell tumor
- Serous
- Unilocular
- Bilateral
- Mucinous
- Multilocular
- Benign
- Most Common
49 secs
Ovarian Cystadenocarcinoma
- Non-germ Cell Tumor
- Mucinous
- Peritoneal Spread
- Serous
- Psammoma Bodies
- Bilateral
- Malignant
- Stromal Invasion
- CA 125
- BRCA-1 and Lynch Syndrome
1 min
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