NP Shared "M3. Immunological Pathology: Innate Immunity, Inflammation, Wound Healing" - 23 Picmonics
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M3. Immunological Pathology: Innate Immunity, Inflammation, Wound Healing
Innate Immunity Barriers
- Skin Protects Against Pathogens
- Normal Flora Outcompete Pathogens
- Lysozyme in Saliva, Tears, and Mucus
- Mucous Traps Pathogens
- Cilia Remove Mucus
- Acid and Digestive Enzymes in the Stomach Kill Pathogens
2 mins
Inflammatory Response
- Pathogens Infect Tissue
- Mast Cells Release Histamine
- Histamine Dilates and Increases Capillary Permeability
- Macrophages Engulf Pathogens
- Macrophage Signals Cells With Cytokines
- Responding Neutrophils Cross Capillary Wall
- B And T Lymphocytes Arrive At Injury Site
2 mins
Immune System Tissues
- Characteristics
- Bone Marrow
- B Cells and T Cells Formed
- B Cells Mature
- Thymus
- T Cells Tested For Self-Response
- T Cells Mature
- Lymph Nodes
- Mature B Cells and T Cells Monitor Lymph For Pathogens
- Spleen
- Mature B Cells and T Cells Monitor Blood For Pathogens
1 min
Prednisone (Glucocorticoids)
- Mechanism
- Glucocorticoid
- Indications
- Inflammatory Conditions
- Organ Transplant Rejection
- Side Effects
- Cataracts and Glaucoma
- Cushing's Syndrome
- Osteoporosis
- Immunosuppression
- Hyperglycemia
- Ulcers
- Considerations
- Adrenal Insufficiency
- Taper Gradually
2 mins
Cyclosporine (Sandimmune) Overview
- Mechanism
- Immunosuppressant
- Inhibits Calcineurin, Decreasing IL-2
- Indications
- Prevent Transplant Rejection
- Psoriasis
- Rheumatoid Arthritis
- Considerations
- Monitor Plasma Levels
- Avoid Grapefruit Juice
- Increased Risk of Lymphoma
2 mins
Cell Surface Proteins - B Cells
- Ig
- CD19
- CD20
- CD21
- CD40
- MHC II
- B7
1 min
Pediatric Vaccinations - Age 12 to 15 Months
- 1 Very MAD HIP-ster
- Varicella Zoster
- MMR
- Hepatitis A
- DTaP - Diphtheria Tetanus acellular pertussis
- HiB - Haemophilus Influenzae Type B
- IPV - Inactivated Polio Vaccine
- PCV - Pneumococcal
2 mins
Pediatric Vaccinations Age 4-6 Years
- Very DIM between 4-6pm
- Varicella Zoster
- DTaP - Diphtheria Tetanus acellular pertussis
- IPV - Inactivated Polio Vaccine
- MMR
1 min
Primary Immune Thrombocytopenia
- Characteristics
- Following Infection or Vaccination
- Antiplatelet Antibodies
- Clinical Features
- Often Asymptomatic
- Bleeding
- Petechiae
- Diagnosis
- Thrombocytopenia
- Increased Megakaryocytes
- Management
- Corticosteroids
- Intravenous Immunoglobulin (IVIG)
- Rituximab
- Splenectomy
4 mins
IL-12 Receptor Deficiency
- Pathophysiology
- IL-12 Secreted by Macrophages
- Decreased Th1 Response
- Decreased IFN Gamma
- Signs and Symptoms
- Mycobacterial Infections
- Salmonella
1 min
Hyper IgE Syndrome
- Job Syndrome (Autosomal Dominant Hyper IgE Syndrome)
- Pathophysiology
- Autosomal Dominant
- STAT3 Mutation
- Increased IgE
- Abnormal Chemotaxis
- Signs and Symptoms
- Leonine Facies
- Cold (Non-Inflamed) Staph Aureus Abscesses
- Retained Primary Teeth
- Eczema
- Management
- Prophylactic Antibiotics
2 mins
Hyper IgM Syndrome
- Pathophysiology
- Deficient CD40 Ligand on Helper T-cells
- Defective CD40 Receptor on B-cells
- Inability to Class Switch
- Signs and Symptoms
- Pyogenic Abscess
- Decreased IgG, IgA, IgE
4 mins
Selective IgA Deficiency
- Pathophysiology
- Defect in Class Switching
- Decreased IgA
- Signs and Symptoms
- Often Asymptomatic
- Increase in Atopic & Autoimmune Diseases
- Sinopulmonary Infections
- Increased Risk Giardia Lamblia Infections
- Inflammatory Bowel Disease
- Celiac Disease
- Considerations
- Anaphylaxis From IgA Containing Blood Products
2 mins
Leukocyte Adhesion Deficiency
- Pathophysiology
- Autosomal Recessive
- Integrin CD18 Protein
- Defect in LFA-1
- Attached to ICAM
- Signs and Symptoms
- Neutrophilia
- Bacterial Infections
- Non-Pyogenic
- Delayed Separation of Umbilical Cord
2 mins
Common Variable Immunodeficiency
- Pathophysiology
- Defect in B Cell Maturation
- Decreased Plasma Cells
- Decreased Immunoglobulins
- Signs & Symptoms
- Sinopulmonary Infections
- Increased Risk of Autoimmune Disease
- Lymphoma
1 min
Severe Combined Immunodeficiency (SCID)
- Both B and T Cell Deficiency
- Recurrent Viral, Bacterial, Fungal, Protozoal Infections
- Defective Interleukin (IL) 2 Receptor
- X-Linked
- Adenosine Deaminase Deficiency
- Failure to Synthesize MHC II Antigens
- Treat with Bone Marrow Transplant
2 mins
Complement Disorders
- Early Complement Deficiency
- Pyogenic Infections
- SLE
- Sinus Infections
- Terminal Complement Deficiency
- Autosomal Recessive
- Neisseria Infections
- C5-C9
- MAC (Membrane Attack Complex)
4 mins
C1 Esterase Inhibitor Deficiency
- Pathophysiology
- Autosomal Dominant
- Disinhibition of Kallikrein
- Increased Bradykinin
- Decreased C4
- Clinical Features
- Recurrent Angioedema
- Upper Airway Obstruction
- Considerations
- ACE Inhibitors Contraindicated
- Avoid Triggers
3 mins
Autoimmune Hepatitis
- Chronic Inflammatory Disease
- Most Common in Females
- Symptoms
- Asymptomatic
- Fatigue
- Nausea
- Pruritus
- Diagnosis
- Antinuclear antibody (ANA)
- Anti-smooth Muscle
- Anti-Liver/Kidney Microsomal-1 Antibodies
- Increased AST/ALT
- Histology
- Portal and Periportal Lymphoplasmacytic Infiltrate
- Treatment
- Prednisone
- Azathioprine
2 mins
Types of Wound Healing
- Types of Wounds
- Acute
- Chronic
- Healing Process
- Primary Intention
- Approximated Edges
- Secondary Intention
- Edges Not Approximated
- Tertiary Intention
- Delayed Closure due to Infection and Necrosis
2 mins
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