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Joshua Shared "TC6 drugs - Cancer drugs" - 14 Picmonics

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TC6 drugs - Cancer drugs

Cyclophosphamide
Mechanism
Requires Bioactivation by Liver
Cross-links DNA
Guanine N7 Position
Indications
Autoimmune Disorders
Leukemia
Lymphoma
Solid Tumors
Side Effects
Myelosuppression
Hemorrhagic Cystitis
Prevent with Mesna
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3 mins
Cisplatin
Indications
Carcinomas
Ovarian
Bladder
Lung
Testicular
Mechanism
Cross-Links DNA
Side Effects
Ototoxicity
Nephrotoxicity
Treat with Amifostine and Chloride Diuresis
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2 mins
Busulfan
Indications
CML
Bone Marrow Ablation
Mechanism
Cross-Links DNA
Side Effects
Myelosuppression
Pulmonary Fibrosis
Hyperpigmentation
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55 secs
Fluorouracil (5-FU)
Mechanism
Antimetabolite
"Thymine-less Death"
Indications
Slow-growing Solid Tumors
Co-administered with Leucovorin for Stomach Cancer
Basal Cell Carcinoma (Topical)
Side Effects
Myelosuppression
Mucositis
Severe Diarrhea
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3 mins
Methotrexate
Indications
Rheumatoid Arthritis
Cancer
Medical Abortion
Mechanism
Folic Acid Analog
Inhibits Dihydrofolate Reductase
Side Effects
Pulmonary Fibrosis
Myelosuppression is Treated with Leucovorin Rescue (Folinic Acid)
Macrocytic Anemia
Hepatitis
Teratogenic
Mucositis
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2 mins
Azathioprine (Imuran)
Mechanism
Antimetabolite
Prodrug of 6-mercaptopurine (6-MP)
Inhibits Synthesis of Nucleic Acids
Indications
Autoimmune Disorders
Kidney Transplantation
Side Effects
Myelosuppression
Increased Toxicity with Allopurinol Use
Pancreatitis
Malignancy
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3 mins
Vincristine (Oncovin)
Mechanism
Vinca Alkaloid
Inhibits Microtubules
Indications
Leukemias
Lymphomas
Side Effects
Peripheral Neuropathy
Paralytic Ileus
Considerations
Vesicant
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2 mins
Etoposide
Indications
Small Cell Lung Cancer
Testicular Cancer
Mechanism of Action
Inhibits Topoisomerase II
Errors in DNA Synthesis Cause Apoptosis
Side Effects
Myelosuppression
Alopecia
Hypotension
Nausea and Vomiting
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2 mins
Bleomycin
Indications
Testicular Cancer
Hodgkin's Lymphoma
Mechanism of Action
Induces Free Radical Formation
Breaks in DNA Strands
Side Effects
Pulmonary Fibrosis
Skin Changes
Mucositis
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1 min
Bevacizumab Mechanisms and Indications
Mechanisms
Monoclonal Antibody to VEGF
Inhibits Angiogenesis (and Vasculogenesis)
Indications
Capillaries Grow CORN (CG-CORN acronym)
Colorectal Cancer
Glioblastoma
Cervical Cancer
Ovarian Cancer
Renal Cell Carcinoma
Non-small Cell Lung Cancer (NSCLC)
Age-related Macular Degeneration
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2 mins
Doxorubicin (Adriamycin)
Indications
Solid Tumors
Lymphomas and Leukemias
Mechanism
Free Radical Production
Intercalates DNA
Prevents Double Helix from Sealing
Side Effect
Cardiotoxicity
Dexrazoxane Decreases Toxicity
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1 min
Imatinib (Gleevec)
Indications
Chronic Myelogenous Leukemia (CML)
Inhibitor of BCR-ABL Tyrosine Kinase
Caused by Philadelphia Chromosome
GI Stromal Tumors
Inhibitor of C-kit Tyrosine Kinase
Toxicity
Fluid Retention
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1 min
Hydroxyurea
Mechanism
Inhibits Ribonucleotide Reductase
Decreased DNA Synthesis
S-phase Specific
Indications
Melanoma
Chronic Myelogenous Leukemia (CML)
Sickle Cell Disease
Through Increased HbF (Fetal Hemoglobin)
Side Effects
Myelosuppression
GI Distress
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2 mins
Trastuzumab
Indications
HER-2+ Breast Cancer
Stomach Cancer
Mechanism
Monoclonal Antibody Against HER-2
Inhibition of Cellular Signaling
Cytotoxicity
Side effects
Cardiotoxicity
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1 min

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