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PT3 EX6
Intro - Cancer and Cancer Chemo Part 1 PT
Malignant Tumors
Carcinogenesis promoters
Intro - Cancer Staging PT
TNM
T in TNM Staging
N in TNM staging
M in TNM Staging
Numerical Cancer Classification
Stage 1
Stage 2
Stage 3
Stage 4
Numerical
Intro - Cancer - Staging and Workup - Classification PT
Simplified staging process we use classification according to?
Stage I
Stage 2
Stage 3
Stage 4
Intro - Cancer Markers PT
Tumor Markers
Produced by some cancers that are characteristic of that particular cancer
Nonspecific
Elevated in?
More useful in monitoring?
Intro 2 - Primary Modalities PT
Primary Modalities of Cancer Treatment
Surgery
Radiation
Systemic Anticancer Therapy
Intro 2 - Adjuvant Therapy PT
Adjuvant Therapy
Definition of Adjuvant therapy?
Intro 2 - Neoadjuvant Therapy PT
Neodajuvant
Definition of Neoadjuvant Therapy
Goal of Pre-operative Therapy?
Intro 2 - Response Criteria Solid Tumors
Complete Response
Partial Response
Progressive Disease
Intro 2 - Administration of Chemo
What lab values should be obtained prior to medication administration?
Chemotherpay dosed based on?
How are chemotherapy regimens administered?
Most chemotherapy cycles are administered every how many weeks?
Complications Part 1 - Myelosuppression
What typically occurs first in myelosuppression?
Why does neutropenia occur first?
What occurs after neutropenia in myelosuppression?
Why are platelets affected next after neutropenia in myelosuppression?
This change in platelets results in?
What is affected last in myelosuppression?
Why are erythrocytes the last to be affected in myelosuppression?
Myelosuppression includes what 3 states?
Neutropenia is defined as
What comprises ANC?
What is the treatment for neutropenia?
What is the most common ADR of Neutropenia treatment medications?
What is the mainstay treatment for Thrombocytopenia?
What is the mainstay treatment of symptomatic or sever chemo induced anemia?
Lowest Blood cell count is called?
Nadir usually occurs in what time span of chemo tx
What time frame does recovery usually occur?
When would ESA be considered and when would there be complications
Complications - Mucositis Treatment
What is in commercial or compounded magic mouthwash used for Mucositis?
Inflammation (Mucositis) can lead to?
Prevention of Mucositis
What chemotherapy agents are most most commonly associated mucositis include
Lung Cancer NSCLC vs SCLC
What is the second most common malignancy in the US?
Define the occurrence and NSCLC vs SCLC
Lung cancer is the MOST Common cause of?
NSCLC or SCLC - Which is the more common occurrence?
Which is faster growing and more aggressive?
How is NSCLC staged vs SCLC?
Describe the response in Radiation/Chemo in NSCLC vs SCLC
EQ! Treatment of SLCC
Side effect of Etoposide?
Complications - Mucosal damage
Mucosal damage in cancer patients?
Lower GI tract complications manifest as?
Monitoring?
Diarrhea - Medicinal Treatment?
Non-Pharm Interventions?
What anticancer agent cause acute or delayed diarrhea and how should it be managed?
First line treatment for Immune mediated diarrhea ?
Lung Cancer NSCLC Types
What are the types of NSCLC?
Adenocarcinoma
Squamous Cell
Large Cell Carcinoma
Lung Cancer Chemoprevention
Lung Cancer NSCLC Staging and Tx
What is the treatment for Stage I NSCLC?
What is the treatment for Stage 2 NSCLC?
What is the treatment for Stage 3A andMost of 3B Locally Advanced NSCLC?
What is the primary treatment for Stage 3B/Cunresectable NSCLC?
What is the secondary treatment for Stage 3B/Cunresectable NSCLC?
What is the tertiary treatment for Stage 3B/Cunresectable NSCLC?
What is the last line treatment for Stage 3B/Cunresectable NSCLC?
Lung Cancer NSCLC Advanced Stage IV and Relapse
If a patient has only a single metastaticsite what is the treatment?
What are the Stage IV Goals?
What are the Stage IV Treatment ECOG Tx factors
What are the Stage IV Pathways for NSCLC? (There are 3 of them)
Lung Cancer NSCLC - Advanced Stage IV - Squamous vs Non-squamous histology TX
Stage V -->
What is the treatment for No-mutation/PD-L1 Neg?
What is the treatment for Non- squamous NSCLC
Lung Cancer - NSCLC Tx Genomics - PD-L1 Inhibitors
What are the PD-L1 Inhibitors that end in -Lizumab
What are the PD-L1 Inhibitors that end in -limab
What ae teh PD-L1 inhibotrs that end in -lumab
What should be used in conjunction with Nivolumab?
Lung Cancer - NSCLC Tx - EGFR Exon 19 Deletion or EGFR I858R
What are the EGFR Exon 19 deletion or EGFR I858R Mutations that end in mer-tinib
What are the EGFR Exon 19 deletion or EGFR I858R Mutations that end in lotinib?
What are the EGFR Exon 19 deletions or EGFR I858R mutations that end in fatinib?
Lung Cancer - NSCLC Tx - ALK Rearrangements
What are the NSCLC ALK Rearrangements?
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