Alexander Shared "MSK Week 2" - 19 Picmonics
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MSK Week 2
Skeletal Muscle Contraction Action
- Characteristics
- Calcium Binds Troponin
- Active Site Exposed
- Many Mitochondria Produce ATP
- Myosin Head Binds
- Power Stroke
- Myosin Head Releases Active Site
- ATP Consumed
1 min
Skeletal Muscle Contraction Initiation
- Somatic Motor Neuron Releases Acetylcholine
- Acetylcholine Causes Sodium Influx
- Cell Reaches All-or-Nothing Threshold
- Voltage-Gated Calcium Channels Undergo Conformational Change
- Sarcoplasmic Reticulum Causes Calcium Flood
- Calcium Flood Enters Myofibrils
1 min
Muscle Types
- Characteristics
- Skeletal Muscle
- Somatic Nervous System
- Striated
- Multinucleate
- Cardiac Muscle
- Autonomic Nervous System
- Myogenic
- Gap Junctions
- Uninucleate
- Smooth Muscle
2 mins
Muscle Energy
- Characteristics
- Active
- Direct
- Types
- Reciprocal Inhibition
- Respiratory Assistance
- Post-Isometric Relaxation
- Isotonic
- Isolytic
- Contraindications
- Critically Ill
- Fractures
- Acute Injury
3 mins
Nondepolarizing Neuromuscular Blocking Drugs
- Names Include "Cur"
- Competitive Antagonists
- Acetylcholine Competition
- Reversal of Blockade
- Neostigmine, Edrophonium
1 min
Succinylcholine
- Indications
- Inducing Paralysis
- Mechanism of Action
- Neuromuscular Blocking Drugs
- Motor Nicotinic Receptor
- ACh Receptor Agonist
- Depolarization
- Phases of Action
- Phase I (Paralysis Non-reversible)
- Phase II (Paralysis Reversible)
- Neostigmine (Reversal Agent)
2 mins
Lambert-Eaton Syndrome
- Mechanism
- Autoantibody to the Presynaptic Calcium Channel on Motor Neurons
- Inhibits Acetylcholine (ACh) Release at Neuromuscular Junction
- Paraneoplastic Syndrome
- Small Cell Lung Cancer
- Symptoms
- Proximal Muscle Weakness
- Improves with Muscle Use
- Autonomic Symptoms
- Extraocular Muscle Sparing
2 mins
Clostridium botulinum
- Characteristics
- Bacillus
- Gram-positive
- Anaerobe
- Spore-forming
- Heat Labile Toxin
- Inhibits Acetylcholine (Ach) Release at Neuromuscular Junction (NMJ)
- Canned Food in Adults
- Spores in Honey
- Signs and Symptoms
- Descending Flaccid Paralysis
- Diplopia
- Ptosis
- Floppy Baby
- Constipation
2 mins
Clostridium tetani
- Characteristics
- Gram-Positive
- Bacilli
- Obligate Anaerobic
- Exotoxin
- Spore-Forming
- Renshaw Cells in the Spinal Cord
- Blocks Glycine and GABA Release
- Signs and Symptoms
- Spasms
- Risus Sardonicus
- Lockjaw
- Opisthotonus
3 mins
11 Beta-Hydroxylase Deficiency
- Pathophysiology
- Decreased Cortisol
- Decreased Aldosterone
- Increased Sex Hormones
- Increased 11 Deoxycorticosterone (11 DOC)
- Signs and Symptoms
- Hypertension
- Masculinization
1 min
Staphylococcus aureus Disease
- Skin Infections
- Impetigo
- Abscesses
- Exfoliative Toxin
- Scalded Skin Syndrome
- Toxic Shock Syndrome (TSST 1)
- Binds to MHC II and T Cell Receptor
- Food Poisoning
- Acute Bacterial Endocarditis
- Pneumonia
- Osteomyelitis
2 mins
Clostridium perfringens
- Characteristics
- Gram-Positive
- Rod-Shaped
- Anaerobe
- Spore-Forming
- Alpha Toxin Lecithinase
- Phospholipase
- Double-Zone Hemolysis
- Heat Labile Enterotoxin
- Signs and Symptoms
- Myonecrosis
- Gas Gangrene
- Food Poisoning and Diarrhea
- Treatment
- Hyperbaric O2 Chamber
2 mins
Corynebacterium diphtheriae
- Characteristics
- Gram-Positive
- Bacillus
- Exotoxin
- ADP Ribosylation of Elongation Factor 2
- Beta Prophage
- Lysogeny
- Tellurite Agar
- Chinese Letters
- Metachromatic Blue Red Granules
- Aniline Stains Deeply Methylene Blue
- Signs and Symptoms
- Pseudomembranous Pharyngitis
- Lymphadenopathy
- Myocarditis
- Polyneuritis
3 mins
Streptococcus pyogenes Characteristics
- Characteristics
- Group A Streptococci (GAS)
- Gram-Positive
- Cocci
- Beta-Hemolytic
- Catalase-Negative
- Bacitracin-Sensitive
- Hyaluronic Acid Capsule
- Streptolysin O
- DNase
- Streptokinase
- Exotoxin A
- Pyrrolidonyl Arylamidase (PYR) Positive
2 mins
Streptococcus Pyogenes Disease
- Pyogenic
- Pyogenic
- Pyogenic Pharyngitis
- Impetigo
- Cellulitis
- Toxigenic
- Toxic Shock-Like Syndrome
- Scarlet Fever
- Sandpaper Rash
- Strawberry Tongue
- Immunologic
- Immunologic
- Rheumatic Fever
- Antibodies to M Protein
- Acute Glomerulonephritis (Post Streptococcal Glomerulonephritis)
2 mins
E. coli Overview
- Characteristics
- Gram-Negative
- Bacillus
- Purple Colony with Metallic Green Sheen
- Lactose-Fermenting
- Pink on MacConkey Agar
- Disease
- Diarrhea
- Lipid A Septic Shock
- P Pili Pyelonephritis and Cystitis
- K Capsule Neonatal Meningitis
- K Capsule Pneumonia
- H Antigen Flagella
2 mins
Glycolysis
- Characteristics
- Glucose
- Hexokinase or Glucokinase
- Glucose-6-phosphate
- Fructose-6-phosphate
- Phosphofructokinase-1 (PFK-1)
- Fructose-1,6-bisphosphate
- Aldolase
- Glyceraldehyde-3-Phosphate
- 1,3-bisphosphoglycerate
- 3-phosphoglycerate
- 2-phosphoglycerate
- Phosphoenolpyruvate (PEP)
- Pyruvate Kinase
- Pyruvate
- Pyruvate Dehydrogenase
- Acetyl-CoA
4 mins
Anaerobic Respiration
- Cytosol
- Glucose
- Glycolysis
- Substrate-level Phosphorylation
- 2 NADH
- 2 Net ATP
- 2 Pyruvate
- Fermentation
- NAD+ Regeneration
- Waste Byproduct
2 mins
Citric Acid Cycle (Krebs Cycle)
- Characteristics
- Acetyl-CoA + Oxaloacetate
- Citric Acid
- Isocitric Acid
- Produces NADH
- Alpha-Ketoglutaric Acid
- Produces NADH
- Succinyl CoA
- Produces GTP
- Succinate
- Produces FADH2
- Fumarate
- Uses Water
- Malate
- Produces NADH
- Oxaloacetate
4 mins
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