Carlos Shared "10 Neurology Pharm" - 53 Picmonics

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10 Neurology Pharm

Epinephrine
Mechanism of Action
Alpha Agonist
Beta Agonist
Indications
Hypotension
Anaphylaxis
Allergy
Glaucoma
44 secs
Systemic Effects of Beta-Blockers
Respiratory
Bronchoconstriction
Metabolic
Decreased Insulin
Decreased Glycolysis and Lipolysis
Eye
Reduces Intraocular Pressure
1 min
Brimonidine
Treats Glaucoma
Decreases aqueous humor synthesis directly via Alpha 2
Alpha 2 Agonist
Blurry Vision
Ocular Hyperemia (Red eye)
Foreign body sensation
Ocular allergic reactions and pruritus
Acetazolamide
Indications
Glaucoma
Altitude Sickness
Pseudotumor Cerebri
CHF
Metabolic Alkalosis
Mechanism of Action
Carbonic Anhydrase Inhibitor
Sodium Bicarbonate (NaHCO3) Diuresis
Side Effects
Metabolic Acidosis
Paresthesias
1 min
Direct Cholinomimetics
Muscarinic agonists
Bethanechol
Bladder and Bowels
Methacholine
Bronchoconstriction
Pilocarpine
Contracts ciliary muscle and pupillary sphincter
Carbachol
Releases intraocular pressure
1 min
Indirect Cholinomimetics
Acetylcholinesterase Inhibitors
Doesn't Cross BBB
Edrophonium
Myasthenia Gravis (Diagnosis)
Pyridostigmine and Neostigmine
Myasthenia Gravis (Tx)
Ileus
Crosses BBB
Physostigmine
Atropine Overdose
Glaucoma
Donepezil
Alzheimer's
2 mins
Latanoprost (PGF2Alpha) and Bimatoprost
Prostaglandin F2-alpha Analog
Increases outflow of aqueous humor
Darkens color of iris (browning)
Eyelash growth
First line treatment for Glaucoma
Opioids Overview
Indications
Pain
Weaning
Cough
Diarrhea
Mechanism of Action
Agonists at Mu (μ), Kappa (Κ), and Delta (δ) Receptors
Decrease Synaptic Transmission
Side Effects
Respiratory Depression
Addiction
Miosis
Constipation
2 mins
Morphine
Mechanism
Opioid Receptor Agonist
Indications
Pain
Myocardial Infarction
Side Effects
Nausea and Vomiting
CNS Depression
Biliary Colic
Constipation
Increased Intracranial Pressure (ICP)
Pupillary Constriction
Hypotension
2 mins
Meperidine (Demerol)
Mechanism
Opioid Receptor Agonist
Indications
Moderate to Severe Pain
Post Anesthesia Shivering
Side Effects
Tremors
Constipation
CNS Depression
Sedation
Considerations
Short Term Administration
Increased Risk Serotonin Syndrome
Does NOT cause Miosis
Renal Failure Increases Toxicity Risk
2 mins
Codeine
Mechanism
Opioid Receptor Agonist
Indications
Mild to Moderate Pain
Cough Suppressant
Side Effects
Sedation
Constipation
Miosis
Considerations
Close Monitoring When Breast Feeding
Often Combined with Non-Opioids
2 mins
Butorphanol
Indications
Migraine
Severe Pain
Labor
Mechanism of Action
Partial Agonist at Mu and Full Agonist at Kappa Receptors
Less Respiratory Depression
Side Effects
Withdrawal Symptoms
1 min
Tramadol
Indications
Chronic Pain
Mechanism of Action
Weak Opioid
Inhibit Serotonin and NE reuptake
Side Effect
Increased Risk of Seizure
47 secs
Pentazocine
Mechanism
κ-opioid receptor agonist
μ-opioid receptor antagonist
Indications
Analgesia for moderate to severe pain
Side Effect
Can cause opioid withdrawal symptoms if patient is also taking full opioid agonist (competition for opioid receptors)
Ethosuximide
Indications
First Line Absence Seizure Treatment
Mechanism of Action
Blocks Thalamic T-Type Ca2+ Channels
Side Effects
Stevens-Johnson Syndrome
Fatigue
Diarrhea
32 secs
Barbiturates
Barb- Drug Names
Indications
Seizure Treatment
Anesthesia Induction
Mechanism of Action
Increased Duration of Cl- Channel Opening
Decrease Neuron Firing
Side Effects
Sedation
Cardiovascular and Respiratory Depression
CNS Depression
P450 inducer
2 mins
Phenytoin
Indications
Status Epilepticus
Tonic-Clonic Seizures
Mechanism of Action
Blocks Na+ Channel Activation
Inhibition of Glutamate Release
Class IB Antiarrhythmic
Side Effects
Teratogenic
Macrocytic Megaloblastic Anemia
Induce Cytochrome P450
Drug-induced Lupus
Neuropathy
Hirsutism
Gingival Hyperplasia
1 min
Carbamazepine
Indications
First-line Seizure Medication
First Line for Trigeminal Neuralgia
Mechanism of Action
Stabilizes Inactive State of Na+ Channels
Side Effects
Stevens-Johnson Syndrome
Induce Cytochrome P450
Teratogen
Hepatotoxicity
Blood Dyscrasias
2 mins
Valproic Acid
Indications
First Line Tonic-Clonic Seizure Treatment
Bipolar Disorder
Migraine Prophylaxis
Mechanism of Action
Increases GABA Concentration
Blocks Voltage-Gated Na+ Channels
Side Effect
GI Distress
Contraindication
Contraindicated in Pregnancy
1 min
Valproic Acid (Valproate) Side Effects
V-A-L-P-R-O-A-T-E
Vomiting
Alopecia
Liver Toxicity
Pancreatitis/Pancytopenia
Retain Fat (Weight Gain)
Oedema (Edema)
Appetite Increase
Tremor
Enzyme Inhibitor (P450)
2 mins

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