OnlineMedEd Shared "Antibacterials - Antimycobacterial" - 7 Picmonics

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Antibacterials - Antimycobacterial

Isoniazid
Indications
Tuberculosis (TB)
Mechanism of Action
Requires Catalase Peroxidase
Decreases Mycolic Acid Synthesis
Fast vs Slow Acetylators
Side Effects
B6 Deficiency
Neurotoxicity
Hepatotoxicity
Drug-induced Lupus
1 min
Isoniazid (INH)
Mechanism
Interferes with DNA Metabolism
Indications
Tuberculosis (TB)
Side Effects
Optic Neuritis
Nausea and Vomiting
Hepatotoxicity
Peripheral Neuropathy
Considerations
Vitamin B6 Prophylaxis
Monitor AST/ALT
2 mins
Rifampin
Tuberculosis (TB)
Blocks RNA Polymerization
Haemophilus influenzae Type B
Leprosy
Meningitis
P450 inducer
Red-orange urine
55 secs
Ethambutol (Myambutol)
Mechanisms
Inhibits RNA Synthesis
Bacteriostatic
Indications
Tuberculosis (TB)
Side Effects
Optic Neuritis
Red/Green Color Blindness
Gouty Arthritis
Consideration
Monitor Vision Acuity
2 mins
Ethambutol
Mechanism of Action
Bacteriostatic
Blocks Arabinosyltransferase
Arabinosyltransferase Polymerizes Carbohydrates
Carbohydrate Polymers Make Mycobacterium TB Cell Wall
Side Effects
Red/Green Color Blindness
Reversible with Drug Discontinuation
39 secs
Mycobacterium Tuberculosis Characteristics
Characteristics
Mycolic Acid Cell Wall
Acid-fast
Carbolfuchsin Stain Red
Lowenstein-Jensen Agar
Serpentine Cord Factor
Primary TB
Primary TB
Caseating Granuloma
Ghon Focus
Hilar Lymph Nodes
Ghon Complex
Reactivation TB
Reactivation TB
Reactivation in Apex
3 mins
Mycobacterium leprae
Aerobic
Acid Fast
Likes Cool Temperature
Tuberculoid leprosy
Granulomatous response
Positive Lepromin Skin Test
Dapsone
Rifampin
Lepromatous leprosy
Weak Immune System
Leonine facies
Negative Lepromin Skin Test
Clofazimine
2 mins

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