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Acute Lymphoblastic Leukemia (ALL)
Ages < 15
May Present with Bone Marrow Involvement in Children
Mediastinal Mass in Adolescents
t(12;21) Better Prognosis
Spread to CNS and Testes
Most Responsive to Chemotherapy
Chronic Myelogenous Leukemia (CML)
Signs & Symptoms
Low Alkaline Phosphatase
Age 30 to 90 Years
Responds to Imatinib
Polycythemia Vera Disease
JAK2 Mutation leading to increased red blood cells
Often After Hot Shower
Derives from Germinal Center
Occurs in adults
BCL 2 overexpression
BCL 2 inhibits apoptosis
Bone marrow involvement
Mantle Cell Lymphoma
Activation of Cyclin D Gene
Adolescents or young adults
C-myc gene moves next to heavy chain Ig gene
Starry sky appearance
Sheets of lymphocytes with interspersed macrophages
Jaw lesion in endemic (African) form
Pelvis or abdomen in non endemic form (American form)
Associated with EBV
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