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Signs and Symptoms
Massive Proteinuria > 3.5g per Day
Increased risk of infection
LM Thickening of Capillary and Glomerular Basement Membrane (GBM)
EM Spike and Dome Appearance with Subepithelial Deposits
Phospholipase A2 Receptor Autoantibodies
Hepatitis B Virus (HBV)
Minimal Change Disease
Most Common in Children
May be Triggered by Recent Infection or Immune Stimulus
On Electron Microscopy (EM) See Foot Process (Podocyte) Effacement
On Light Microscopy (LM) See Normal Glomeruli
Loss of Negative Charge
Selective Loss of Albumin
Responds to Corticosteroids
Focal Segmental Glomerulosclerosis
Most Common Cause of Nephrotic Syndrome in Hispanics and African Americans
Associated with Sickle Cell Disease and HIV
Associated Interferon Therapy and Heroin Abuse
LM Segmental Sclerosis and Hyalinosis
EM Focal Damage of Visceral Epithelial Cells
Signs & Symptoms
Subendothelial Immune Complexes
Hepatitis C Virus
Tram Tracks Caused by Splitting of the GBM
Ingrowth of Mesangium
Dense Deposit Disease
C3 Nephritic Factor
Nonenzymatic Glycosylation of Glomerular Basement Membrane
Nonenzymatic Glycosylation of Arterioles
Type IV Collagen Deposition
Kimmelstiel Wilson Lesions
Congo Red Stain
Apple Green Birefringence
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