Emily Shared "Path" - 13 Picmonics
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Path
Chondrosarcoma
- Pathophysiology
- Cartilaginous tumor
- Malignant
- Men 30-60 years old
- Pelvic and femur bones
- Signs & Symptoms
- Glistening mass in medullary cavity
- Can be primary in origin or from osteochondroma
- Metastasize to lungs
1 min
Ewing's Sarcoma
- Epidemiology
- Most Common in Boys < 15 years old
- Pathophysiology
- 11;22 Translocation
- Characteristics
- Long bones, Pelvis, Ribs
- Diaphysis
- Small Blue Cells
- Malignant
- Aggressive
- Onion-skin Appearance
- TREATMENT
- Responsive to Chemotherapy
2 mins
Giant Cell Tumor
- Pathophysiology
- Osteoclastoma
- Epiphyseal End of Long Bones
- Peak Incidence 20-40 Years
- Benign
- Knee Region
- Diagnosis
- Soap Bubble Appearance on X-ray
- Spindle-shaped Cells
- Multinucleated Giant Cells
46 secs
Guillain-Barre Syndrome Assessment
- Assessment
- Ascending Paralysis
- Muscle Weakness
- Paresthesias (Pins and Needles)
- Diplopia
- Difficulty Speaking
- Dysphagia
- Labile Blood Pressure
- Loss of Bowel and Bladder Control
- Considerations
- Aggressive Airway Management
2 mins
McArdles Disease
- Pathophysiology
- Type V Glycogen Storage Disease
- Muscle Glycogen Phosphorylase Deficiency
- Signs and Symptoms
- Increased Glycogen in Muscle
- Painful Muscle Cramps
- Myoglobinuria
- Normal Lactic Acid
- Treatment
- Vitamin B6
2 mins
Osteoporosis Assessment
- Highest Risk
- Postmenopausal Women
- Long Term Corticosteroids
- Assessment
- Kyphosis
- Dowager's Hump
- Loss of Height
- Back Pain
- Pathologic Fractures
- Spinal Compression Fracture
1 min
Osteoporosis Interventions
- Increased Calcium Intake
- Vitamin D Supplements
- Bisphosphonates
- Raloxifene
- Denosumab
- Calcitonin
- Teriparatide
- Bone Densitometry (DEXA) Scan
- Weight Bearing Exercises
2 mins
Osteosarcoma
- Pathophysiology
- Osteogenic Sarcoma
- Peak incidence men 10-20 years old
- Metaphysis of Long Bones
- Knee Region
- Radiation
- Familial Retinoblastoma
- Paget's Disease
- Diagnosis
- Codman Triangle
- Sunburst Pattern from Elevated Periosteum
- Grave Prognosis
2 mins
Paget's Disease of Bone
- Pathophysiology
- Men > Age 40
- Increased Osteoblast and Osteoclast activity
- Mosaic Pattern
- Signs and Symptoms
- Increased Skull Diameter
- Hearing Loss
- Fractures
- Bone Ache and Joint Pain
- High Output Heart Failure
- Diagnosis
- Bone Scan
- Normal Parathyroid hormone (PTH) and Calcium
- Elevated ALP
- Treatment
- Bisphosphonate
- Calcitonin
2 mins
Polymyositis / Dermatomyositis Diagnosis and Treatment
- Diagnosis
- Increased CK (CPK)
- Increased Aldolase
- Anti-JO-1 Antibody
- Anti-SRP Antibody
- Antinuclear Antibody
- Abnormal EMG
- Biopsy
- Treatment
- Corticosteroids
- Methotrexate
- Azathioprine
- Treatment For Resistant Disease
- Intravenous Immunoglobulin (IVIG)
- Cyclophosphamide
- Rituximab
- Calcineurin Inhibitors
2 mins
Polymyositis / Dermatomyositis Disease
- Pathophysiology
- Idiopathic Inflammatory Myopathy
- More Common in Women
- Endomysial Inflammation with CD8+ Cells (Polymyositis)
- Perimysial Inflammation with CD4+ Cells (Dermatomyositis)
- Signs and Symptoms (Both)
- Symmetric Proximal Muscle Weakness
- Dysphagia
- Lung and Cardiac Involvement
- Signs and Symptoms (Dermatomyositis)
- Malar Rash
- Shawl-like Shoulder Rash
- Gottron Papules on Knuckles
- Heliotrope Rash
3 mins
Pompe Disease
- Pathophysiology
- Type II Glycogen Storage Disease
- Autosomal Recessive
- Deficiency of Lysosomal Alpha 1,4 Glucosidase
- Acid Maltase
- Signs and Symptoms
- Hypertrophic Cardiomyopathy
- Hepatomegaly
- Macroglossia
- Hypotonia
- Diagnosis
- Increased Glycogen within Lysosomes
- Increased Lactate Dehydrogenase (LDH)
- Increased Creatine Kinase (CK/CPK)
2 mins
Von Gierke Disease
- Pathophysiology
- Autosomal Recessive
- Type I Glycogen Storage Disease
- Glucose-6-Phosphatase Deficiency
- Signs and Symptoms
- Increased Glycogen in Liver
- Hepatomegaly
- Enlarged Kidneys
- Severe Fasting Hypoglycemia
- Increased Triglycerides
- Increased Uric Acid (Gout)
- Increased Lactic Acid
- Doll-like Facies
- Treatment
- Continuous Oral Glucose (or Cornstarch)
- Avoid Fructose and Galactose
2 mins
