Gregory Shared "Pharm Antineoplastic drugs" - 16 Picmonics
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Pharm Antineoplastic drugs
Methotrexate
- Indications
- Rheumatoid Arthritis
- Cancer
- Medical Abortion
- Mechanism
- Folic Acid Analog
- Inhibits Dihydrofolate Reductase
- Side Effects
- Pulmonary Fibrosis
- Myelosuppression is Treated with Leucovorin Rescue (Folinic Acid)
- Macrocytic Anemia
- Hepatitis
- Teratogenic
- Mucositis
2 mins
Fluorouracil (5-FU)
- Mechanism
- Antimetabolite
- "Thymine-less Death"
- Indications
- Slow-growing Solid Tumors
- Co-administered with Leucovorin for Stomach Cancer
- Basal Cell Carcinoma (Topical)
- Side Effects
- Myelosuppression
- Mucositis
- Severe Diarrhea
3 mins
Cytarabine
- Pyrimidine analog
- inhibits DNA polymerase
- Treats Leukemias and Lymphomas
- Causes myelosuppression with megaloblastic anemia
- Causes pancytopenia
Cladribine
- Purine (Adenosine) Analog
- Also called Leukostatin
- Mechanism of Action
- Inhibits Adenosine Deaminase
- Inhibits Viral DNA Polymerase
- Use
- Hairy Cell Leukemia
- Multiple sclerosis
- Side Effects
- Myelosuppression
- Nephrotoxicity
- Neurotoxicity
Vincristine (Oncovin)
- Mechanism
- Vinca Alkaloid
- Inhibits Microtubules
- Indications
- Leukemias
- Lymphomas
- Side Effects
- Peripheral Neuropathy
- Paralytic Ileus
- Considerations
- Vesicant
2 mins
Paclitaxel (Taxanes)
- Mechanism of Action
- Taxane
- Stabilizes Microtubules
- Indications
- Breast Cancer
- Ovarian Cancer
- Non-Small Cell Lung Cancer
- Kaposi Sarcoma (HHV-8)
- Side Effects
- Mucositis
- Myelosuppression
- Peripheral Neuropathy
- Hypersensitivity
- Alopecia
- Considerations
- Diphenhydramine (Benadryl)
2 mins
Cyclophosphamide
- Mechanism
- Requires Bioactivation by Liver
- Cross-links DNA
- Guanine N7 Position
- Indications
- Autoimmune Disorders
- Leukemia
- Lymphoma
- Solid Tumors
- Side Effects
- Myelosuppression
- Hemorrhagic Cystitis
- Prevent with Mesna
3 mins
Busulfan
- Indications
- CML
- Bone Marrow Ablation
- Mechanism
- Cross-Links DNA
- Side Effects
- Myelosuppression
- Pulmonary Fibrosis
- Hyperpigmentation
55 secs
Cisplatin
- Indications
- Carcinomas
- Ovarian
- Bladder
- Lung
- Testicular
- Mechanism
- Cross-Links DNA
- Side Effects
- Ototoxicity
- Nephrotoxicity
- Treat with Amifostine and Chloride Diuresis
2 mins
Doxorubicin (Adriamycin)
- Indications
- Solid Tumors
- Lymphomas and Leukemias
- Mechanism
- Free Radical Production
- Intercalates DNA
- Prevents Double Helix from Sealing
- Side Effect
- Cardiotoxicity
- Dexrazoxane Decreases Toxicity
1 min
Bleomycin
- Indications
- Testicular Cancer
- Hodgkin's Lymphoma
- Mechanism of Action
- Induces Free Radical Formation
- Breaks in DNA Strands
- Side Effects
- Pulmonary Fibrosis
- Skin Changes
- Mucositis
1 min
Trastuzumab
- Indications
- HER-2+ Breast Cancer
- Stomach Cancer
- Mechanism
- Monoclonal Antibody Against HER-2
- Inhibition of Cellular Signaling
- Cytotoxicity
- Side effects
- Cardiotoxicity
1 min
Cetuximab and Panitumumab
- Mechanism
- Monoclonal Antibodies Against EGFR
- Indications
- Colorectal Cancer
- Head and Neck Cancer
- Ménétrier Disease
- Side Effects
- Elevated LFTs
- Rash
- Diarrhea
- Hypokalemia
- Hypomagnesemia
1 min
Bevacizumab Side Effects
- Impaired (Delayed) Wound Healing
- Hemorrhage
- Nosebleed (Epistaxis)
- GI Perforation
- Thromboembolic Event
- Osteonecrosis of the Jaw
1 min
Imatinib (Gleevec)
- Indications
- Chronic Myelogenous Leukemia (CML)
- Inhibitor of BCR-ABL Tyrosine Kinase
- Caused by Philadelphia Chromosome
- GI Stromal Tumors
- Inhibitor of C-kit Tyrosine Kinase
- Toxicity
- Fluid Retention
1 min
Erlotinib
- Mechanism of Action
- Inhibits EGFR Tyrosine Kinase
- Inhibits Progression of G1 to S Phase
- Indications
- Non-small Cell Lung Cancer (NSCLC)
- Pancreatic Cancer
- Side Effects
- Rash
- Diarrhea
- Considerations
- Avoid Grapefruit Juice
1 min
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