Andrea Shared "Pharm II Midterm" - 39 Picmonics
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Pharm II Midterm
Paclitaxel (Taxanes)
- Mechanism of Action
- Taxane
- Stabilizes Microtubules
- Indications
- Breast Cancer
- Ovarian Cancer
- Non-Small Cell Lung Cancer
- Kaposi Sarcoma (HHV-8)
- Side Effects
- Mucositis
- Myelosuppression
- Peripheral Neuropathy
- Hypersensitivity
- Alopecia
- Considerations
- Diphenhydramine (Benadryl)
2 mins
Hydroxyurea
- Mechanism
- Inhibits Ribonucleotide Reductase
- Decreased DNA Synthesis
- S-phase Specific
- Indications
- Melanoma
- Chronic Myelogenous Leukemia (CML)
- Sickle Cell Disease
- Through Increased HbF (Fetal Hemoglobin)
- Side Effects
- Myelosuppression
- GI Distress
2 mins
Leukemia Interventions
- Diagnosis
- Bone Marrow Aspiration
- X-Rays
- Interventions
- Chemotherapy
- Bleeding Precautions
- Neutropenic Precautions
- Strict Asepsis
- Bone Marrow Transplant
- Blood Transfusions
- Monitor Temperature Elevations
- Adequate Nutrition
- Imatinib (Gleevec) for Chronic Myelogenous Leukemia (CML)
3 mins
Ondansetron
- Indications
- Postoperative Vomiting
- Chemotherapy-induced Nausea and Vomiting
- Mechanism
- 5-HT3 Serotonergic Antagonist
- Centrally-acting Antiemetic
- Side Effects
- Headache
- Constipation
- QT Prolongation
1 min
Hodgkin's Lymphoma Interventions
- Diagnosis
- Biopsy
- Staging
- Interventions
- Radiation
- Chemotherapy
- Treat Side Effects of Therapy
- Considerations
- Secondary Cancer Screening
2 mins
Breast Cancer Interventions
- Radiation or Chemotherapy
- Hormonal Therapy
- Tamoxifen
- Lumpectomy
- Mastectomy
- Avoid BP and Injections Affected Arm
- Hand Exercises
- Considerations
- Grief Related to Body Image
- Prosthetics
- Reconstruction
- Lymphedema
3 mins
Cisplatin
- Indications
- Carcinomas
- Ovarian
- Bladder
- Lung
- Testicular
- Mechanism
- Cross-Links DNA
- Side Effects
- Ototoxicity
- Nephrotoxicity
- Treat with Amifostine and Chloride Diuresis
2 mins
Vincristine (Oncovin)
- Mechanism
- Vinca Alkaloid
- Inhibits Microtubules
- Indications
- Leukemias
- Lymphomas
- Side Effects
- Peripheral Neuropathy
- Paralytic Ileus
- Considerations
- Vesicant
2 mins
Sickle Cell Anemia (Management)
- Long Term Treatment
- Hydroxyurea
- Bone Marrow Transplant
- Folate
- Acute Treatment
- Exchange Transfusion
- Prophylaxis
- Penicillin Prophylaxis
1 min
Cetuximab and Panitumumab
- Mechanism
- Monoclonal Antibodies Against EGFR
- Indications
- Colorectal Cancer
- Head and Neck Cancer
- Ménétrier Disease
- Side Effects
- Elevated LFTs
- Rash
- Diarrhea
- Hypokalemia
- Hypomagnesemia
1 min
Cyclophosphamide
- Mechanism
- Requires Bioactivation by Liver
- Cross-links DNA
- Guanine N7 Position
- Indications
- Autoimmune Disorders
- Leukemia
- Lymphoma
- Solid Tumors
- Side Effects
- Myelosuppression
- Hemorrhagic Cystitis
- Prevent with Mesna
3 mins
Methotrexate
- Indications
- Rheumatoid Arthritis
- Cancer
- Medical Abortion
- Mechanism
- Folic Acid Analog
- Inhibits Dihydrofolate Reductase
- Side Effects
- Pulmonary Fibrosis
- Myelosuppression is Treated with Leucovorin Rescue (Folinic Acid)
- Macrocytic Anemia
- Hepatitis
- Teratogenic
- Mucositis
2 mins
Rituximab
- Indications
- Chronic Lymphocytic Leukemia (CLL)
- Non-Hodgkin Lymphoma
- Rheumatoid Arthritis
- Microscopic Polyangiitis (MPA)
- Granulomatosis with Polyangiitis (Formerly Wegener's)
- Mechanism
- Monoclonal Antibody Against CD20
- Found on B Cell Neoplasms
- Side Effects
- Infusion Reactions
- Skin and Mouth Reactions
- Reactivation of Hepatitis B Virus (HBV)
- Progressive Multifocal Leukoencephalopathy (PML)
3 mins
Doxorubicin (Adriamycin)
- Indications
- Solid Tumors
- Lymphomas and Leukemias
- Mechanism
- Free Radical Production
- Intercalates DNA
- Prevents Double Helix from Sealing
- Side Effect
- Cardiotoxicity
- Dexrazoxane Decreases Toxicity
1 min
Cell-Cycle Specificity of Anticancer Drugs
- G2 phase drugs intercalate DNA
- Bleomycin can cause damage to the lungs
- Doxorubicin is cardiotoxic
- M-phase drugs
- M-phase drugs inhibit Mitosis
- Vinblastine and Vincristine block tubular polymerization
- Placlitaxel blocks Depolymerization of microtubules
- S-Phase drugs Block DNA systhesis
- Antimetabolites block the S-phase of the cell cycle
Imatinib (Gleevec)
- Indications
- Chronic Myelogenous Leukemia (CML)
- Inhibitor of BCR-ABL Tyrosine Kinase
- Caused by Philadelphia Chromosome
- GI Stromal Tumors
- Inhibitor of C-kit Tyrosine Kinase
- Toxicity
- Fluid Retention
1 min
Cetuximab
- EGFR Inhibitor
- Colon Cancer
- Non-small Cell Lung Cancer (NSCLC)
- Head and Neck Cancer
- Acne-like Rash
- Allergic Reaction
- Diarrhea
- Elevated liver enzymes
- Erlotinib, Afatinib
Dopamine
- Indications
- Heart Failure
- Shock
- Unstable Bradycardia
- Mechanism of Action
- Alpha 1 Agonist (at high doses)
- Induces Vasoconstriction
- Beta-1 & 2 Agonist
- Dopamine 1 and 2 Agonist
- Side Effects
- Arrhythmias
- Nausea and Vomiting
- Kidney Damage
- Gangrene
3 mins
Ergot Alkaloid: Bromocriptine
- Mechanism of Action
- D2 receptor AGONIST
- D1 receptor ANTagonist
- Contraindication
- Coronary Heart Disease
- Hypertension
- Peripheral vascular disease
- Side Effects
- Nausea and Vomiting
- Tardive Dyskinesia
- Hallucinations
- Indications
- Migraine
- Parkinson's Disease
52 secs
Dexamethasone
- Decadron
- Corticosteroid
- Inflammation
- Cytokines
- Severe allergies and asthma
- Hypertension
- Cushing syndrome
- Monitor weight, blood pressure, electrolytes
- Glucose levels
- Take with Food
- vision change or loss
2 mins
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