Alyson Shared "Hepatic" - 17 Picmonics
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Hepatic
Liver Enzyme Tests: AST and ALT
- AST/ALT Ratio
- AST: 8-20 U/L
- ALT: 8-20 U/L
1 min
Hepatitis B Treatment
- Tenofovir
- Pegylated Interferon-Alpha
- Entecavir
Hepatitis C therapy
- Interferon alpha
- Flu symptoms, neutropenia, myopathy
- Depression
- Ribavirin
- Competitively inhibits inosine monophosphate dehydrogenase
- Inhibiting guanine nucleotides
- Hemolytic anemia
- Teratogen
- Sofosbuvir
- Inhibits RNA dependent RNA polymerase
- Causing chain termination
- Headache
- Fatigue
- Nausea
- Simeprevir
- Protease Inhibitor
- Prevents viral replication
- Photosensitivity
- Rash
Hepatitis C Therapy
- Ledipasvir
- Inhibits NS5A Protein
- Avoid Antacids
- Sofosbuvir
- Chain Terminator of NS5B Polymerase
- Simeprevir
- Inhibits NS3/4A Protease
- Ribavirin
- No Vaccine Available
Hepatitis C (HCV) Assessment
- Transmission
- Blood Transmission
- High Risk Sex (rare)
- IV Drug Users
- Incubation
- 7 Weeks
- Chronic Disease
- Cirrhosis
- Considerations
- Barrier Protection
2 mins
Protease Inhibitors
- End in "-navir"
- Indications
- HIV/AIDS
- Hepatitis C
- Mechanism
- Inhibit Protease
- Unable to Cleave Proteins
- Inhibits Maturation of New Virus
- Side Effects
- GI Distress
- Nephropathy
- Lipodystrophy
- Hyperglycemia
3 mins
Primary Biliary Cholangitis (Primary Biliary Cirrhosis) Diagnosis and Treatment
- Diagnosis
- Positive Antimitochondrial Antibodies
- Increased Alkaline Phosphatase (ALK-P)
- Increased Cholesterol
- Treatment
- Ursodiol
- Liver Transplant
2 mins
Pancreatin, Pancrelipase (Pancreatic Enzymes)
- Mechanism
- Pancreatic Enzymes
- Indications
- Cystic Fibrosis
- Pancreatic Insufficiency
- Side Effects
- GI Distress
- Considerations
- Inactivated by Gastric Acid
- 24 Hour Fat Excretion
- Take with Every Meal and Snack
2 mins
Acute Pancreatitis Interventions
- NPO with NG Tube to Suction
- Pain Management
- Albumin
- Lactated Ringers Solution
- Proton Pump Inhibitor (PPI)
- Antibiotics
- Surgery
- Nutrition
2 mins
Pancreatic Adenocarcinoma Diagnosis and Treatment
- Diagnosis
- CA 19-9
- Liver Function Tests for Cholestasis
- Serum Lipase
- Ultrasound if Cholestasis Suspected
- CT Abdomen
- FNA Biopsy if Diagnosis or Resectability Uncertain
- Treatment
- Whipple if Resectable
- Palliative Care if Not Resectable
4 mins
BRAF Inhibitors
- Characteristics
- BRAF Proto-oncogene
- Serine/Threonine Kinase
- V600E Mutation
- Indications
- Melanoma
- Non-Hodgkin Lymphoma
- Papillary Thyroid Carcinoma
- Hairy Cell Leukemia
- Drugs
- Dabrafenib
- Vemurafenib
2 mins
Hepatitis A (HAV) Assessment
- Transmission
- Fecal-Oral
- Ingestion of Contaminated Food or Water
- Incubation
- 4 Weeks
- Assessment
- Fever
- General Malaise
- Hepatomegaly
- Considerations
- Self-Limiting
- Proper Hand Washing
2 mins
Hepatitis B Virus Disease
- Can turn chronic
- < 10% of adults become chronic carriers
- 90% of newborns become chronic carriers
- Cirrhosis
- Hepatocellular carcinoma
- Membranous Glomerulonephritis
- Polyarteritis nodosa
- Serum sickness like syndrome
2 mins
Hepatitis B (HBV) Assessment
- Transmission
- Bodily Fluids
- Blood Transmission
- People Who Use IV Drugs
- Incubation
- Variable 1-6 Months
- Assessment
- Fever
- Nausea and Vomiting
- Hepatomegaly
- Chronic Disease
- Cirrhosis
- Hepatocellular Carcinoma
- Considerations
- Vaccination
2 mins
Budd-Chiari Syndrome
- Causes
- Pregnancy and Postpartum
- Hematologic Disorders
- Tumors
- Chronic Infections
- Mechanism
- Thrombosis of Major Hepatic Veins
- Centrilobular Congestion and Necrosis
- Symptoms
- Abdominal Pain
- Ascites
- Hepatomegaly
- Nutmeg Liver
3 mins
Hepatocellular carcinoma (HCC)
- Cirrhosis
- Aspergillus fumigatus
- Budd-Chiari Syndrome
- ↑ AFP
- Spreads hematogenously
- S&Sx
- Jaundice
- Hepatomegaly
- Ascities
- Polycythemia
- Anorexia
Gilbert's Syndrome
- Pathophysiology
- Decreased UDP-Glucuronosyltransferase Activity
- Decreased Bilirubin Conjugation
- Signs and Symptoms
- Often Asymptomatic
- Jaundice (Mild)
- Fasting
- Stress
- Alcohol Intake
- Labs
- Increased Unconjugated Bilirubin
2 mins
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