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BIIC post midterm
Plasmodium Specific
Malariae
Fever Every Three Days
Vivax/Ovale
Fever Every Two Days
Duffy Antigen Binding Site
Duffy often absent in Black Population
Primaquine treats dormant form in liver
Falciparum
Most severe
Irregular Cycles
Occludes capillaries in the brain, kidneys, and lungs
4 mins
Plasmodium General
Characteristics
Protozoa
Malaria
Anopheles Mosquito
Signs and Symptoms
Cyclic Fever
Headache
Anemia
Splenomegaly
Diagnosis
Blood Smear
Treatment
Chloroquine
Mefloquine for Resistant Types
3 mins
Trypanosoma Brucei
Characteristics
Protozoa
Trypanosoma Gambiense
Trypanosoma Rhodesiense
Tsetse Fly
Disease
Painful Bite
African Sleeping Sickness
Recurring Fever
Capacity for Antigenic Variation
Enlarged Lymph Nodes
Encephalitis
Treatment
Suramin for Blood-Borne Disease
Melarsoprol for CNS Penetration
2 mins
Leishmania donovani
Pathophysiology
Protozoan
Visceral Leishmaniasis
Hepatosplenomegaly
Spiking Fevers
Skin Pigmentation
Sandfly
Diagnosis
Macrophages with Amastigotes
Treatment
Amphotericin B
Oral Miltefosine
2 mins
Trypanosoma cruzi
Pathophysiology
Protozoa
Triatomine Bug
Kissing bug
Painless bite
Predominantly in South America
Symptoms
Chagas disease
Romana's sign
Dilated Cardiomyopathy
Megacolon
Megaesophagus
Diagnosis
Blood smear
Treatment
Nifurtimox
Benznidazole
2 mins
Babesia
Characteristics
Protozoa
Ixodes Tick
Same vector as Borrelia
Northeastern US
Asplenia
Signs and Symptoms
Fever
Hemolytic Anemia
Diagnosis
Blood Smear
Maltese Cross
Treatments
Atovaquone
Azithromycin
3 mins
Schistosoma
Pathophysiology
Trematode (Fluke)
Snail-infested Water
Intense Immune Response
Intestinal Disease
Hepatosplenic Granuloma
Squamous Cell Cancer of the Bladder
Diagnosis
Parasitic Antigens via ELISA
Treatment
Praziquantel
2 mins
Bruton's Agammaglobulinemia
Pathophysiology
X-linked Recessive
Defective Bruton Tyrosine Kinase
Blocks B Cell Maturation
Signs & Symptoms
Decreased Immunoglobulins of All Classes
Bacterial Infections After Six Months
Maternal IgG Protects Before Six Months
2 mins
Common Variable Immunodeficiency
Pathophysiology
Defect in B Cell Maturation
Decreased Plasma Cells
Decreased Immunoglobulins
Signs & Symptoms
Sinopulmonary Infections
Increased Risk of Autoimmune Disease
Lymphoma
1 min
Selective IgA Deficiency
Pathophysiology
Defect in Class Switching
Decreased IgA
Signs and Symptoms
Often Asymptomatic
Increase in Atopic & Autoimmune Diseases
Sinopulmonary Infections
Increased Risk Giardia Lamblia Infections
Inflammatory Bowel Disease
Celiac Disease
Considerations
Anaphylaxis From IgA Containing Blood Products
2 mins
Hyper IgE Syndrome
Pathophysiology
Job's Syndrome
Abnormal Chemotaxis
Decreased IFN Gamma
Signs and Symptoms
Leonine Facies
Cold Non-Inflamed Staph Aureus Abscesses
Retained Primary Teeth
Eczema
Red Hair
1 min
IL-12 Receptor Deficiency
Pathophysiology
IL-12 Secreted by Macrophages
Decreased Th1 Response
Decreased IFN Gamma
Signs and Symptoms
Mycobacterial Infections
Salmonella
1 min
Thymic Aplasia (DiGeorge Syndrome)
Pathophysiology
DiGeorge Syndrome
22q11 Deletion
Failure to Develop Third and Fourth Pharyngeal Pouches
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