Jared Shared "BIIC post midterm" - 38 Picmonics
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BIIC post midterm
Plasmodium Specific
- Malariae
- Fever Every Three Days
- Vivax/Ovale
- Fever Every Two Days
- Duffy Antigen Binding Site
- Duffy often absent in Black Population
- Primaquine treats dormant form in liver
- Falciparum
- Most severe
- Irregular Cycles
- Occludes capillaries in the brain, kidneys, and lungs
4 mins
Plasmodium General
- Characteristics
- Protozoa
- Malaria
- Anopheles Mosquito
- Signs and Symptoms
- Cyclic Fever
- Headache
- Anemia
- Splenomegaly
- Diagnosis
- Blood Smear
- Treatment
- Chloroquine
- Mefloquine for Resistant Types
3 mins
Trypanosoma Brucei
- Characteristics
- Protozoa
- Trypanosoma Gambiense
- Trypanosoma Rhodesiense
- Tsetse Fly
- Disease
- Painful Bite
- African Sleeping Sickness
- Recurring Fever
- Capacity for Antigenic Variation
- Enlarged Lymph Nodes
- Encephalitis
- Treatment
- Suramin for Blood-Borne Disease
- Melarsoprol for CNS Penetration
2 mins
Leishmania donovani
- Pathophysiology
- Protozoan
- Visceral Leishmaniasis
- Hepatosplenomegaly
- Spiking Fevers
- Skin Pigmentation
- Sandfly
- Diagnosis
- Macrophages with Amastigotes
- Treatment
- Amphotericin B
- Oral Miltefosine
2 mins
Trypanosoma cruzi
- Pathophysiology
- Protozoa
- Triatomine Bug
- Kissing bug
- Painless bite
- Predominantly in South America
- Symptoms
- Chagas disease
- Romana's sign
- Dilated Cardiomyopathy
- Megacolon
- Megaesophagus
- Diagnosis
- Blood smear
- Treatment
- Nifurtimox
- Benznidazole
2 mins
Babesia
- Characteristics
- Protozoa
- Ixodes Tick
- Same vector as Borrelia
- Northeastern US
- Asplenia
- Signs and Symptoms
- Fever
- Hemolytic Anemia
- Diagnosis
- Blood Smear
- Maltese Cross
- Treatments
- Atovaquone
- Azithromycin
3 mins
Schistosoma
- Pathophysiology
- Trematode (Fluke)
- Snail-infested Water
- Intense Immune Response
- Intestinal Disease
- Hepatosplenic Granuloma
- Squamous Cell Cancer of the Bladder
- Diagnosis
- Parasitic Antigens via ELISA
- Treatment
- Praziquantel
2 mins
Bruton's Agammaglobulinemia
- Pathophysiology
- X-linked Recessive
- Defective Bruton Tyrosine Kinase
- Blocks B Cell Maturation
- Signs & Symptoms
- Decreased Immunoglobulins of All Classes
- Bacterial Infections After Six Months
- Maternal IgG Protects Before Six Months
2 mins
Common Variable Immunodeficiency
- Pathophysiology
- Defect in B Cell Maturation
- Decreased Plasma Cells
- Decreased Immunoglobulins
- Signs & Symptoms
- Sinopulmonary Infections
- Increased Risk of Autoimmune Disease
- Lymphoma
1 min
Selective IgA Deficiency
- Pathophysiology
- Defect in Class Switching
- Decreased IgA
- Signs and Symptoms
- Often Asymptomatic
- Increase in Atopic & Autoimmune Diseases
- Sinopulmonary Infections
- Increased Risk Giardia Lamblia Infections
- Inflammatory Bowel Disease
- Celiac Disease
- Considerations
- Anaphylaxis From IgA Containing Blood Products
2 mins
Hyper IgE Syndrome
- Job Syndrome (Autosomal Dominant Hyper IgE Syndrome)
- Pathophysiology
- Autosomal Dominant
- STAT3 Mutation
- Increased IgE
- Abnormal Chemotaxis
- Signs and Symptoms
- Leonine Facies
- Cold (Non-Inflamed) Staph Aureus Abscesses
- Retained Primary Teeth
- Eczema
- Management
- Prophylactic Antibiotics
2 mins
IL-12 Receptor Deficiency
- Pathophysiology
- IL-12 Secreted by Macrophages
- Decreased Th1 Response
- Decreased IFN Gamma
- Signs and Symptoms
- Mycobacterial Infections
- Salmonella
1 min
Thymic Aplasia (DiGeorge Syndrome)
- Pathophysiology
- DiGeorge Syndrome
- 22q11 Deletion
- Failure to Develop Third and Fourth Pharyngeal Pouches
- Signs and Symptoms
- Undeveloped Thymus
- T Cell Deficiency
- Recurrent Viral and Fungal Infections
- Undeveloped Parathyroids
- Hypocalcemia
- Tetany
- Aortic Defects
- Congenital Heart Defects
- Diagnosis
- Absent Thymic Shadow on CXR
2 mins
Wiskott Aldrich
- Pathophysiology
- X-linked Recessive
- WASp Protein Mutation
- Antigen Presentation Defect
- Progressive Deletion of B and T Cells
- Signs and Symptoms
- Thrombocytopenia
- Eczema
- Infections
- Decreased IgM
- Increased IgE, IgA
2 mins
Hyper IgM Syndrome
- Pathophysiology
- Deficient CD40 Ligand on Helper T-cells
- Defective CD40 Receptor on B-cells
- Inability to Class Switch
- Signs and Symptoms
- Pyogenic Abscess
- Decreased IgG, IgA, IgE
4 mins
Severe Combined Immunodeficiency (SCID)
- Both B and T Cell Deficiency
- Recurrent Viral, Bacterial, Fungal, Protozoal Infections
- Defective Interleukin (IL) 2 Receptor
- X-Linked
- Adenosine Deaminase Deficiency
- Failure to Synthesize MHC II Antigens
- Treat with Bone Marrow Transplant
2 mins
Ataxia Telangiectasia
- Pathophysiology
- Autosomal Recessive
- ATM Gene
- Defect in DNA repair
- Signs & Symptoms
- Cerebellar defects
- Spider Angiomas
- Sensitive to Radiation
- Defective Tumor Suppressor Gene
- Increased risk of Cancer, Leukemias, and Lymphomas
- Increased AFP levels
- IgA deficiency
- Repeated sinopulmonary infections
2 mins
Leukocyte Adhesion Deficiency
- Pathophysiology
- Autosomal Recessive
- Integrin CD18 Protein
- Defect in LFA-1
- Attached to ICAM
- Signs and Symptoms
- Neutrophilia
- Bacterial Infections
- Non-Pyogenic
- Delayed Separation of Umbilical Cord
2 mins
Chronic Granulomatous Disease
- Pathophysiology
- Most Commonly X-linked Recessive
- Defective NADPH Oxidase (Enzyme Complex)
- Decreased Hydrogen Peroxide
- Impaired Intracellular Killing in Phagocytes
- Signs and Symptoms
- Recurrent Purulent Skin and Lung Infections
- Catalase Positive Organisms
- Diagnosis
- Negative Nitroblue Tetrazolium Test
- DHR (Dihydrorhodamine) Flow Cytometry
- Treatment
- Antimicrobial Prophylaxis
- TMP-SMX
- Itraconazole
- Interferon-Gamma
3 mins
Chediak-Higashi Syndrome
- Pathophysiology
- Autosomal Recessive
- Defective Lysosomal Trafficking Regulator Gene (LYST)
- Defect In Microtubular Function
- Decrease In Phagocytosis
- Signs And Symptoms
- Recurrent Pyogenic Infections
- Staph Aureus And Streptococci
- Partial Albinism
- Peripheral Neuropathy
- Pancytopenia
- Diagnosis
- Giant Granules In Granulocytes And Platelets
2 mins
