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Cytogenetics - Disorders of Chromosome Structure
Derives from Germinal Center
Occurs in adults
BCL 2 overexpression
BCL 2 inhibits apoptosis
Bone marrow involvement
Acute Myelogenous Leukemia (AML)
Myeloblasts Increase on Peripheral Smear
Median Onset 60 Years
T 15;17 M3 Subtype
Disseminated Intravascular Coagulation (DIC) is a Common Presentation
M5 Gum Infiltration
Responds to Vitamin A
Most Common in Boys < 15 years old
Long bones, Pelvis, Ribs
Small Blue Cells
Responsive to Chemotherapy
Signs and Symptoms
Septum Primum Type ASD
Endocardial Cushion Defects
Prominent Epicanthal Folds
Increased Risk of Acute Lymphoblastic Leukemia
Acute Lymphoblastic Leukemia (ALL)
Ages < 15
May Present with Bone Marrow Involvement in Children
Mediastinal Mass in Adolescents
t(12;21) Better Prognosis
Spread to CNS and Testes
Most Responsive to Chemotherapy
Adolescents or young adults
C-myc gene moves next to heavy chain Ig gene
Starry sky appearance
Sheets of lymphocytes with interspersed macrophages
Jaw lesion in endemic (African) form
Pelvis or abdomen in non endemic form (American form)
Associated with EBV
Mantle Cell Lymphoma
Activation of Cyclin D Gene
Chronic Myelogenous Leukemia (CML)
Age 30 to 90 Years
Low Alkaline Phosphatase (ALK-P)
Blast Crisis can Accelerate and Transform to AML or ALL
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