Hailey Shared "Pharmacology- block 14" - 36 Picmonics
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Pharmacology- block 14
Leuprolide
- Mechanism
- GnRH Agonist (Pulsatile Use)
- GnRH Antagonist (Continuous Use)
- Upregulates FSH And LH
- Downregulates FSH And LH
- Indications Pulsatile
- Infertility
- Indications Continuous
- Prostate Cancer
- Precocious Puberty
- Uterine Fibroids
- Endometriosis
- Side Effects
- Anti-androgenic Effects
2 mins
Anterior Pituitary
- Characteristics
- Hypothalamic Control
- FLAT PeG Mnemonic
- Tropic Hormones
- Follicle-Stimulating Hormone (FSH)
- Lutenizing Hormone (LH)
- Adrenocorticotropic Hormone (ACTH)
- Thyroid-Stimulating Hormone (TSH)
- Direct Hormones
- Prolactin (PRL)
- Growth Hormone (GH)
2 mins
Oxytocin (Pitocin)
- Mechanism of Action
- Increase Uterine Contractions
- Indications
- Labor Induction
- Control Postpartum Hemorrhage
- Side Effects
- Uterine Rupture
- Water Intoxication
- Contraindications
- Fetal Lung Immaturity
- Cervix Not Ripened
- Active Genital Herpes Infection
- Considerations
- Use Lowest Dose
- IV Pump
3 mins
Hypothalamus
- Characteristics
- Anterior Pituitary Stimulated Through the Hypophyseal Portal
- GHRH
- GnRH
- TRH
- PIF
- CRF Released During Stress
- Posterior Pituitary Stimulated Through Neural Control
3 mins
Posterior Pituitary
- Characteristics
- Neuroendocrine Reflex Stimulation (By Hypothalamus)
- Direct Hormones
- Vasopressin
- Increased Water Retention (In Kidneys)
- Oxytocin
- Increased Uterine Contraction
- Mammary Glands Contraction
2 mins
Nephrogenic Diabetes Insipidus Diagnosis and Management
- Diagnosis
- Hypernatremia
- Normal or Increased Plasma Osmolality
- Decreased Urine Osmolality
- Water Deprivation Test
- Desmopressin Test
- Management
- Stop Triggers
- Thiazide Diuretics
- Amiloride
- Indomethacin
3 mins
Diabetes Interventions
- Early Diagnosis
- Insulin
- Oral Hypoglycemics
- Glucose Monitoring
- Routine Exercise
- Diabetic Diet
- Monitor for Complications
- Insulin Therapy
- Diabetic Ketoacidosis (DKA)
2 mins
Insulin
- Rapid Acting
- Insulin Lispro (Humalog)
- Insulin Aspart (Novolog)
- Insulin Glulisine (Apidra)
- Short Acting
- Regular Insulin (Humulin R)
- Intermediate Acting
- Isophane NPH (Humulin N)
- Long Acting
- Detemir (Levemir)
- Glargine (Lantus)
2 mins
Metformin
- Indications
- Diabetes Mellitus Type 2
- Polycystic Ovary Syndrome (PCOS)
- Mechanism of Action
- Decreased Gluconeogenesis
- Increased Insulin Sensitivity
- Side Effects
- Lactic Acidosis
- GI Distress
- Weight Loss
- B12 Deficiency
- Contraindication
- GFR < 30 ml/min
2 mins
Pioglitazone (Thiazolidinediones)
- -glitazones Suffix
- Mechanism
- Binds PPAR-Gamma
- Decreases Insulin Resistance
- Indications
- Type 2 Diabetes
- Side Effects
- Weight Gain
- Heart Failure
- Myalgia
- Hypoglycemia
- Upper Respiratory Infection
- Considerations
- Increased Risk of Bladder Cancer
- Increased Fracture Risk in Women
- Monitor Liver Enzymes
2 mins
Glyburide and Glipizide (2nd Generation Sulfonylureas)
- Mechanisms
- 2nd Generation Sulfonylureas
- Blocks Potassium Channels in Beta Cells
- Stimulate Release of Insulin
- Indications
- Type 2 Diabetes
- Side Effects
- Hypoglycemia
- Considerations
- More Potent
- Beta Blockers Reduce Effects
- Avoid Alcohol
- Avoid Breastfeeding
2 mins
Repaglinide and Nateglinide (Meglitinides)
- Mechanisms
- Meglitinides
- Increased Insulin Release
- Indications
- Type 2 Diabetes
- Side Effect
- Hypoglycemia
- Considerations
- Eat Within 30 Minutes
- Gemfibrozil Increases Risk of Hypoglycemia
- Short Half-Life
2 mins
Acarbose (Precose) and Miglitol (Glyset) (Alpha Glucosidase Inhibitors)
- Mechanisms
- Alpha Glucosidase Inhibitors
- Delays Absorption of Carbohydrates
- Indications
- Type 2 Diabetes
- Side Effects
- Flatulence
- Diarrhea
- Anemia
- Cramps
- Considerations
- Monitor LFTs
- Oral Glucose for Hypoglycemia
2 mins
Exenatide (Byetta)
- Mechanism
- Incretin Mimetic
- GLP-1 Synthetic Analog
- Indications
- Type 2 Diabetes
- Side Effects
- Hypoglycemia
- Nausea and Vomiting
- Diarrhea
- Thyroid Cancer
- Pancreatitis
- Renal Failure
- Considerations
- (Give Exenatide) One Hour After Other Medications
- Adjunct Therapy
3 mins
Insulin Regulation
- Master Regulator
- Glucose
- Incretins Released with Oral Glucose
- GLP-1
- GIP
- Positive Regulators
- Beta-2 Receptor Stimulation
- M3 Acetylcholine Receptor Stimulation
- Negative Regulators
- Alpha-2 Receptor Stimulation
- Somatostatin
2 mins
Sitagliptin (Januvia) and Saxagliptin (Onglyza) (DPP-4 Inhibitors)
- -gliptin Suffix
- Mechanisms
- DPP-4 Inhibitor
- Increases Insulin Release
- Indications
- Type 2 Diabetes
- Side Effects
- Pancreatitis
- Upper Respiratory Infection and Inflammation
- Stevens-Johnson Syndrome
- Considerations
- Used as Add-on Agents
2 mins
SGLT2 Inhibitors
- "-gliflozin" Suffix
- Mechanism of Action
- Blocks Glucose Reabsorption in Proximal Tubule
- Indications
- Type 2 Diabetes Mellitus
- Side Effects
- Weight Loss
- Lower Blood Pressure
- Hyperkalemia
- Urinary Tract Infections (UTIs)
- Considerations
- Contraindicated in Chronic Kidney Disease
1 min
Azoles (Ketoconazole)
- "-azole" suffix
- Indications
- Local and Less Serious Systemic Mycosis
- Mechanism
- Inhibits Ergosterol Synthesis
- Inhibits P450
- Side Effects
- Liver Dysfunction
- Inhibition of Testosterone Synthesis
1 min
Cushing's Syndrome Characteristics
- More Common in Women
- Exogenous Etiologies
- Glucocorticoids
- Endogenous Etiologies
- Decreased ACTH
- Primary Adrenal Disease
- Increased ACTH
- Pituitary Adenoma (Cushing's Disease)
- Paraneoplastic: Small Cell Carcinoma
- CRF-releasing Tumors
2 mins
Cushing's Syndrome Symptoms And Diagnosis
- Symptoms/Findings
- Osteoporosis
- Amenorrhea
- Truncal Obesity
- Skin Changes
- Buffalo Hump
- Immune Suppression
- Moon Facies
- Hypertension
- Decreased Insulin Sensitivity
- Diagnosis
- 24-hour urine free Cortisol
- Dexamethasone Suppression Test
2 mins
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