Mohamed Shared "chronic exam 4" - 35 Picmonics
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chronic exam 4
Alport Syndrome
- Pathophysiology
- Nephritic
- X-linked
- Mutation in Type IV Collagen
- Diagnosis
- Split Basement Membrane
- Basket Weave Appearance
- Signs and Symptoms
- Ocular Disorders
- Deafness
2 mins
Autosomal Dominant Polycystic Kidney Disease
- Characteristics
- Autosomal Dominant
- Mutations in PKD1/2
- Cystic Enlargement of Renal Tubules
- Clinical Features
- Chronic Kidney Disease
- Hypertension
- Mitral Valve Prolapse
- Hepatic Cysts
- Berry (Saccular) Aneurysms
3 mins
Berger's Disease (IgA Nephropathy)
- Nephritic
- IgA Nephropathy
- Immune Complex Deposit in Mesangium
- Increased Synthesis of IgA
- Most Common Cause of Nephritic Syndrome
- Overlapping Features with Henoch–Schönlein Purpura
- Presents with Pharyngitis, URI or Acute Gastroenteritis
1 min
Choriocarcinoma
- Germ-cell tumor
- Trophoblastic tissue
- Hematogenous spread to lungs
- Malignant
- Theca-lutein cysts
- Hydatidiform Mole
- hCG
59 secs
Diffuse Proliferative Glomerulonephritis (DPGN)
- Nephritic and Nephrotic Syndrome
- Associations
- Systemic Lupus Erythematosus (SLE)
- IgA Nephropathy
- Characteristics
- Wire Looping
- IF Granular
- Subendothelial Immune Complexes
- Subepithelial Immune Complexes
- C3 Deposition
- Treatment
- Treat Underlying Disorder
- Steroids
2 mins
Henoch-Schonlein Purpura
- Most Common Childhood Vasculitis
- Follows Pharyngeal or Respiratory Infection
- Palpable Purpura on Legs and Buttocks
- Arthralgia
- Intestinal Hemorrhage
- Black Stool (Melena)
- Associated with IgA Nephropathy
2 mins
K+ Sparing Diuretics
- Indications
- CHF and Hypertension
- Hypokalemia
- Hyperaldosteronism
- Mechanism of Action
- Collecting Tubule
- Spironolactone
- Competitive Aldosterone Receptor Antagonist
- Amiloride and Triamterene
- Block Na+ Channels
- Side Effects
- Hyperkalemia
- Gynecomastia
2 mins
Membranous Glomerulonephritis
- Characteristics
- Nephrotic
- Diagnosis
- LM Thickening of Capillary and Glomerular Basement Membrane (GBM)
- EM Spike and Dome Appearance with Subepithelial Deposits
- IF Granular
- Primary
- Phospholipase A2 Receptor Autoantibodies
- Secondary
- NSAIDS
- Gold
- Solid Tumors
- Hepatitis B Virus (HBV)
- Lupus
3 mins
Minimal Change Disease
- Pathophysiology
- Nephrotic
- Most Common in Children
- May be Triggered by Recent Infection or Immune Stimulus
- Diagnosis
- On Electron Microscopy (EM) See Foot Process (Podocyte) Effacement
- On Light Microscopy (LM) See Normal Glomeruli
- Loss of Negative Charge
- Selective Loss of Albumin
- Treatment
- Responds to Corticosteroids
2 mins
Nephritic Syndrome
- Inflammatory
- Hematuria
- RBC casts
- Increased Nitrogen in blood
- Oliguria
- Hypertension
- Proteinuria < 3.5 grams per day
2 mins
Post Streptococcal Glomerulonephritis
- Pathophysiology
- Nephritic
- Children
- Signs and Symptoms
- Edema
- Cola Colored Urine
- Follows Group A Streptococcal pharyngitis or Skin Infection
- Diagnosis
- Neutrophils
- Immunofluorescence (IF) Granular
- Lumpy Bumpy Appearance on Immunofluorescence (IF)
- Subepithelial Immune Complex Humps
2 mins
Prostate Adenocarcinoma Characteristics and Presentation
- Characteristics
- Most Common Cancer in Men
- Screening Test if Suspicious
- Prostate Specific Antigen (PSA)
- Peripheral Zone
- Risk Factors
- African American
- Advanced Age
- Presentation
- Usually Asymptomatic
- Terminal Hematuria
- Urinary Retention or Incontinence
- Lower Back Pain
2 mins
Rapidly Progressive Glomerulonephritis
- Pathogenesis
- Nephritic Syndrome
- Crescent Shape
- Crescents Consist of Fibrin and C3b
- With Parietal Cells, Monocytes, and Macrophages
- IMMUNOFLUORESCENCE
- Linear Immunofluorescence
- Negative Immunofluorescence
- Granular Immunofluorescence
- Etiology
- Goodpasture Syndrome
- Granulomatosis with Polyangiitis (Formerly Wegener's)
- Microscopic Polyangiitis
- Prognosis
- Poor Prognosis
3 mins
Renal Cell Carcinoma Characteristics
- Pathophysiology
- Chromosome 3
- VHL Gene
- Proximal Convoluted Tubule
- Risk Factors
- Smoking
- Nephrolithiasis
- Chronic Analgesic Use
- Subtypes
- Clear Cell
- Papillary
- Chromophobic
2 mins
Squamous Cell Carcinoma of the Bladder Clinical Features
- Risk Factors
- Smoking
- Chronic Cystitis
- Schistosoma
- Chronic Nephrolithiasis
- Clinical Findings
- Painless Hematuria
- Urinary Frequency and Urgency
1 min
Testicular Carcinoma Assessment
- Cause/Mechanism
- Seminoma Germ Cells
- Non-Seminoma Germ Cells
- Assessment
- Painless Scrotal Mass
- Testicular Swelling
- Acute Pain Rare
- Elevated Serum Tumor Markers
- Considerations
- Males Between 15-35 Years Old
- Cryptorchidism
- Testicular Self Exam
2 mins
Transitional Cell Carcinoma
- Most Common Cause Of Lower Urinary Tract Cancer
- Risk factors
- Cyclophosphamide
- P-SAC
- Cigarette Smoke
- Azo Dyes, Alcohol, Anilines (Dyes, Rubber)
- Older Adult
- Signs and Symptoms
- Painless Hematuria
3 mins
Tuberous Sclerosis
- Characteristics
- Autosomal Dominant
- Signs and Symptoms
- Hamartomas in CNS and Skin
- Phakoma
- Subependymal Giant Cell Astrocytoma
- Seizures
- Intellectual Disability (Mental Retardation)
- Adenoma Sebaceum
- Shagreen Patch
- Ash-leaf Spots
- Renal Angiomyolipoma
- Cardiac Rhabdomyoma
2 mins
Von Hippel-Lindau Disease
- Pathophysiology
- Chromosome 3
- Presentation
- Hemangioblastomas
- Medulla, Retina, Cerebellum
- Cysts
- Kidney, Liver, Pancreas
- Develop Bilateral Renal Carcinomas
- Pheochromocytomas
2 mins
Wilms' Tumor (Nephroblastoma)
- Cause
- Malignant Renal Tumor
- Assessment
- Abdominal Mass
- Hematuria
- Fever
- Hypertension
- Interventions
- Nephrectomy
- Chemotherapy
- Radiation
- Considerations
- Do Not Palpate Abdomen
- Children Under 5 Years Old
2 mins
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