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F. Pharm: Gonadal
Mechanism of Action
Selective Estrogen Receptor Modulator (SERM)
Antagonist on Breast Tissue
ER-positive Breast Cancer
Decreased Risk of Osteoporosis
Increased Risk of Endometrial Cancer
Increased Risk of Venous Thromboembolism (VTE)
Increased Calcium Intake
Vitamin D Supplements
Bone Densitometry (DEXA) Scan
Weight Bearing Exercises
Ovulatory Hormones I - Follicular Phase
GnRH Stimulates FSH and LH
Follicle Secretes Estrogen
Negative Feedback from Estrogen
Increased Estrogen Leads to Positive Feedback
FSH and LH Surge
LH Spike Leads to Ovulation
Estrogen Receptor-positive (ER+) Breast Tumors
Ovulatory Hormones II - Luteal Phase
Negative Feedback inhibits FSH and LH
No pregnancy forms Corpus Albicans
Stops Estrogen Secretion
Endometrial Sloughing - Menses
GnRH secretion produces new follicular phase
Benign Prostatic Hyperplasia (BPH) Diagnosis and Treatment
Digital Rectal Exam
Urinalysis to Detect Infection or Blood
5 Alpha Reductase Inhibitors
TURP (Transurethral Resection of Prostate)
Local and Less Serious Systemic Mycosis
Inhibits Ergosterol Synthesis
Inhibition of Testosterone Synthesis
Inhibition of Aldosterone
Avoid Potassium Supplements
K+ Sparing Diuretics
CHF and Hypertension
Mechanism of Action
Competitive Aldosterone Receptor Antagonist
Amiloride and Triamterene
Block Na+ Channels
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