Catriona Shared "Immuno extra" - 7 Picmonics

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Immuno extra

Interleukins
IL-1 (Macrophage)
Neutrophil & Macrophage Migration
Fever & Shock
IL-2 (T-Cells)
T-Cells Proliferation
NK & Macrophage Activity
B-Cell Growth
IL-3 (T-Cells)
Hematopoisis
IL-4 (Th2)
Th2 Cell Differentiation
B-Cell Growth
Isotype Switch to IgE
IL-5 (Th2)
Eosinophil Differentiation
Isotype Switch to IgA
IL-6 (Macrophage)
T & B Cell Growth
Osteoclast Activity
Fever
IL-8 (Macrophages T-Cells)
Neutrophil Chemotaxis
IL-10 (Th2)
Blocks TH1 Differentiation
Decreases cell-mediated immunity & APC activity
Increase B-Cell Function
IL-12 (Macrophage)
Th1 Differentiation
Increase NK and CD8 Activity
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IL-12
Produced by
Macrophages
Received by
TH1 cells
NK Cells
Results in
IFN-gamma
Granulomatous Inflammation
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IL-5
Production
Secreted by Eosinophils
Secreted by TH2 cells
Secreted by Mast Cells
Functions
IgA Production
Differentiation of B cells
Eosinophil Production
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Interleukin 4
Induces Differentiation of T cells to TH2 Cells
Promotes Growth of B Cells
Enhances Class Switching to IgE and IgG
Inhibits TH to TH1
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Lymph Drainage
Trachea and Esophagus
Lung
Liver, Stomach, Spleen, Pancreas, and Upper Duodenum
Lower D, J, Ileum, and colon to splenic flexure
Colon to Upper rectum
Lower Rectum to Anal Canal
Bladder, Vagina, Cervix, and Prostate
Testes, Ovary, Kidney, and Uterus
Anal Canal, Skin Below Umbiliucs, Scrotum, and Vulva
Dorsolateral Foot, and Posterior Calf
Medial Foot
Glans Penis and Clitoris
Iliac
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Interleukin (IL) 8
Clean up on aisle 8
chemotactic factor for neutrophils
Made by Macrophages
Leukotriene B4
5- HETE
C5a
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Interferon alpha (IFNa)
Indications
HBV, HCV (chronic)
HPV 6,11 (Condyloma Acuminata)
Hairy Cell Leukemia
HHV-8 (Kaposi Sarcoma)
Renal Cell Carcinoma (RCC)
Malignant Melanoma
Side effects
Flu-like symptoms, pancytopenia, retinopathy, SI/HI
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