Catriona Shared "Immuno extra" - 7 Picmonics
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Immuno extra
Interleukins
- IL-1 (Macrophage)
- Neutrophil & Macrophage Migration
- Fever & Shock
- IL-2 (T-Cells)
- T-Cells Proliferation
- NK & Macrophage Activity
- B-Cell Growth
- IL-3 (T-Cells)
- Hematopoisis
- IL-4 (Th2)
- Th2 Cell Differentiation
- B-Cell Growth
- Isotype Switch to IgE
- IL-5 (Th2)
- Eosinophil Differentiation
- Isotype Switch to IgA
- IL-6 (Macrophage)
- T & B Cell Growth
- Osteoclast Activity
- Fever
- IL-8 (Macrophages T-Cells)
- Neutrophil Chemotaxis
- IL-10 (Th2)
- Blocks TH1 Differentiation
- Decreases cell-mediated immunity & APC activity
- Increase B-Cell Function
- IL-12 (Macrophage)
- Th1 Differentiation
- Increase NK and CD8 Activity
IL-12
- Produced by
- Macrophages
- Received by
- TH1 cells
- NK Cells
- Results in
- IFN-gamma
- Granulomatous Inflammation
IL-5
- Production
- Secreted by Eosinophils
- Secreted by TH2 cells
- Secreted by Mast Cells
- Functions
- IgA Production
- Differentiation of B cells
- Eosinophil Production
Interleukin 4
- Induces Differentiation of T cells to TH2 Cells
- Promotes Growth of B Cells
- Enhances Class Switching to IgE and IgG
- Inhibits TH to TH1
Lymph Drainage
- Trachea and Esophagus
- Lung
- Liver, Stomach, Spleen, Pancreas, and Upper Duodenum
- Lower D, J, Ileum, and colon to splenic flexure
- Colon to Upper rectum
- Lower Rectum to Anal Canal
- Bladder, Vagina, Cervix, and Prostate
- Testes, Ovary, Kidney, and Uterus
- Anal Canal, Skin Below Umbiliucs, Scrotum, and Vulva
- Dorsolateral Foot, and Posterior Calf
- Medial Foot
- Glans Penis and Clitoris
- Iliac
Interleukin (IL) 8
- Clean up on aisle 8
- chemotactic factor for neutrophils
- Made by Macrophages
- Leukotriene B4
- 5- HETE
- C5a
Interferon alpha (IFNa)
- Indications
- HBV, HCV (chronic)
- HPV 6,11 (Condyloma Acuminata)
- Hairy Cell Leukemia
- HHV-8 (Kaposi Sarcoma)
- Renal Cell Carcinoma (RCC)
- Malignant Melanoma
- Side effects
- Flu-like symptoms, pancytopenia, retinopathy, SI/HI
