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Rachael
Systemic Lupus Erythematosus (SLE) Diagnosis and Clinical Features
IM DAMN SHARP acronym
Immunoglobulins
Malar rash
Discoid rash
Antinuclear antibody
Mucositis
Neurologic disorders
Serositis
Hematologic disorders
Arthritis
Renal disorders
Photosensitivity
2 mins
Ankylosing Spondylitis
Chronic Inflammatory Arthritis
"Bamboo Spine"
HLA-B27
Uveitis
Aortic Regurgitation
1 min
HLA-B27 Associations
Associations
PAIR Acronym
Psoriatic Arthritis
Ankylosing Spondylitis
Inflammatory Bowel Disease
Reactive Arthritis
1 min
TNF-Alpha Inhibitors Overview
Mechanism
Downregulates Pro-inflammatory Cytokines
Decreased Lymphocyte Activation and Migration
Granuloma Breakdown
Treats
Crohn's Disease
Rheumatoid Arthritis
Juvenile Rheumatoid Arthritis
Psoriasis
Ankylosing Spondylitis
1 min
TNF-Alpha Inhibitor Drugs and Complications
Etanercept
Decoy TNF- Alpha receptor
Anti-TNF- Alpha antibody
Adalimumab
Infliximab
Complications
Increased risk of infection
Predispose to Tuberculosis (TB) reactivation
Order Baseline PPD- skin test
Quantiferon Gold In-Tube
Order Chest X-Ray
2 mins
Neisseria Meningitidis
Characteristics
Gram-Negative
Diplococci
Chocolate Agar
Thayer-Martin Media
VPN
Oxidase-Positive
Maltose Fermentation
Glucose Fermentation
Endotoxin
Lipooligosaccharide (LOS) in Membrane
Polysaccharide Capsule
IgA Protease
Disease
Waterhouse Friderichsen Syndrome
Adrenal Insufficiency
Petechial Rash
Treatments
Ceftriaxone
Rifampin Prophylaxis
5 mins
Neisseria gonorrhoeae Disease
Signs & Symptoms
Dysuria
Pelvic Inflammatory Disease (PID)
Fitz-Hugh-Curtis Syndrome
Neonatal Conjunctivitis
Pharyngitis
Septic Arthritis
Tenosynovitis
Pustules On Hands And Feet
Treatment
Ceftriaxone
Azithromycin
Doxycycline
Considerations
C5-9 Complement Deficiency (Recurrent Infections)
2 mins
Pox Virus
Characteristics
Enveloped
Double-Stranded DNA
Linear
Non-Icosahedral
Signs and Symptoms
Smallpox
Cowpox
Molluscum Contagiosum
Umbilicated Flesh-Colored Domed Lesions
1 min
Human Papillomavirus (HPV)
Characteristics
Non-enveloped
Circular
Double Stranded DNA
Disease
Warts 1, 2, 6, 11
Condyloma acuminata
Type 16, 18
Cervical Carcinoma
Penile Carcinoma
AIDS/Immunocompromised
Worsened by Smoking
Diagnosis
Koilocytic change in squamous epithelium
Pyknotic Nuclei Surrounded by Clear Halo
Treatment
Vaccine Available
4 mins
Chronic Mucocutaneous Candidiasis
Mechanism and Characteristics
T Cell Dysfunction
Candida Albicans
Signs and Symptoms
Infections of Skin
Infections of Mucous Membrane
Susceptible to HPV Infections like Condyloma Acuminatum
Resistant to Beta Lactams Due to Altered Penicillin Binding Proteins (PBPs)
2 mins
Staphylococcus epidermidis
Characteristics
Cocci
Gram-Positive
Catalase-Positive
Urease-Positive
Coagulase-Negative
Novobiocin-Sensitive
Component of Normal Skin Flora
Infects Prosthetic Devices and IV Catheters
Contaminates Blood Cultures
Produces Adherent Biofilms
2 mins
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